MEDICAL DEVICES HAVING POLYMERIC REGIONS WITH IMPROVED ADHESION
    2.
    发明授权
    MEDICAL DEVICES HAVING POLYMERIC REGIONS WITH IMPROVED ADHESION 有权
    随着高分子地区的医疗器械具有改进的粘附

    公开(公告)号:EP2054100B1

    公开(公告)日:2011-03-23

    申请号:EP07809931.4

    申请日:2007-06-25

    IPC分类号: A61L31/02 A61L31/14 A61L31/04

    摘要: According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain at least one polymeric region in contact with a metallic region. The polymeric region contains at least one block copolymer that contains at least one low Tg block and at least one high Tg block. The polymeric region contains at least one polymer that contains at least one adhesion promoting group selected from one or more of halo-silane, alkoxy-silane, epoxy, anhydride, phenoxy, hydroxyl, amino, sulfonate and carboxyl groups, which at least one polymer may correspond to the block copolymer, a supplemental polymer, or both.

    PROCESS FOR PRODUCING POLYMER COATING THROUGH SURFACE POLYMERISATION
    4.
    发明公开
    PROCESS FOR PRODUCING POLYMER COATING THROUGH SURFACE POLYMERISATION 审中-公开
    一种用于生产包衣聚合物通过表面聚合

    公开(公告)号:EP1490124A2

    公开(公告)日:2004-12-29

    申请号:EP03721531.6

    申请日:2003-04-04

    IPC分类号: A61L31/16 A61L31/10

    摘要: A medical device with a therapeutic agent-releasing polymer coating. The medical device is provided by a method that comprises: (a) attaching at least one reactive species to a medical device surface, which reactive species leads to chain growth polymerization in the presence of monomer; (b) contacting the reactive species with at least one monomer species, thereby forming a polymer coating on the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating. The therapeutic agent may be incorporated during formation of the polymer coating or after formation of the polymer coating. The at least one reactive species can comprise, for example, a free radical species, a carbanion species, a carbocation species, a Ziegler-Natta polymerization complex, a metallocene complex, and/or an atom transfer radical polymerization initiator. Alternatively, the medical device is provided by a process comprising: (a) immobilizing least one polymerization catalyst at a medical device surface, which polymerization catalyst leads to polymerization in the presence of monomer; (b) contacting the medical device surface with at least one monomer species, thereby forming a polymer coating at the surface of the medical device; and (c) providing at least one therapeutic agent within the polymer coating.