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公开(公告)号：EP2089072B1
公开(公告)日：2014-06-04
申请号：EP07837562.3
申请日：2007-08-30
发明人： BENCO, John , BODEN, Mark , BRITO, Shaina , NAIMARK, Wendy , PHAM, Lan
CPC分类号： A61L31/148 , A61L27/227 , A61L27/34 , A61L27/50 , A61L27/54 , A61L27/58 , A61L31/047 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/608
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公开(公告)号：EP2054097A2
公开(公告)日：2009-05-06
申请号：EP07753874.2
申请日：2007-03-22
发明人： BODEN, Mark
CPC分类号： A61K47/32 , A61K47/34 , A61L27/34 , A61L27/54 , A61L29/085 , A61L29/16 , A61L31/10 , A61L31/16 , A61L2300/00 , C08L101/005
摘要： According to an aspect of the present invention, internal medical devices are provided, which contain at least one surface region that comprises a polymer brush. The polymer brush, in turn, contains one or more types of hydrophobic polymer chains and one or more types of hydrophilic polymer chains.
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3.发明授权MEDICAL DEVICES HAVING POLYMERIC REGIONS BASED ON VINYL ETHER BLOCK COPOLYMERS 有权随着高分子地区的医疗设备基于VINYLETHERBLOCKCOPOLYMEREN
公开(公告)号：EP2019698B1
公开(公告)日：2014-11-12
申请号：EP07776989.1
申请日：2007-05-11
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4.发明公开MEDICAL DEVICES HAVING POLYMERIC REGIONS BASED ON STYRENE-ISOBUTYLENE COPOLYMERS 有权基于苯乙烯 - 异丁烯共聚物聚合物地区的医疗器械
公开(公告)号：EP2114478A2
公开(公告)日：2009-11-11
申请号：EP08726087.3
申请日：2008-02-26
发明人： LINDQUIST, Jeffrey, S. , STRICKLER, Frederick, H. , BODEN, Mark , SEPPALA, Jan , MILLER, Paul, J.
CPC分类号： A61L31/048 , A61L27/16 , A61L27/34 , A61L29/041 , A61L29/085 , A61L31/10 , C08L53/02
摘要： According to an aspect of the present invention, implantable or insertable medical devices are provided, which contain one or more polymeric regions. These polymeric regions, in turn, contain one or more polymers, at least one of which is a copolymer that includes a styrene monomer and an isobutylene monomer. Moreover, the styrene monomer content of the copolymer typically ranges from 25 to 50 mol %.
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公开(公告)号：EP2120787A1
公开(公告)日：2009-11-25
申请号：EP08726181.4
申请日：2008-02-27
发明人： HELMUS, Michael, N. , TENNEY, Barron , XU, Yixin , ALVES, Kevin, M. , STRICKLER, Frederick, H. , MILLER, Kathleen, M. , BODEN, Mark
CPC分类号： A61F2/07 , A61F2/06 , A61F2/915 , A61F2002/009 , A61F2002/072 , A61F2002/075 , A61F2250/0024 , A61L27/427 , A61L27/56 , A61L31/128 , A61L31/146
摘要： According to an aspect of the present invention, long term medical articles are provided which include the following: (a) first and second body contacting (e.g., tissue and/or body-fluid contacting) porous polymeric layers; (b) a polymeric barrier layer disposed between the first and second porous polymer layers; and (c) a reinforcement element. According to another aspect of the present invention, tubular medical articles for long term implantation are provided, which comprise: (a) a reinforcement element; (b) a blood contacting porous polymeric layer having a surface energy ranging between 20 and 30 dynes/cm disposed over an inner surface of the reinforcement element; and (c) an additional porous polymeric layer formed over an outer surface of the reinforcement element.
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公开(公告)号：EP2089072A2
公开(公告)日：2009-08-19
申请号：EP07837562.3
申请日：2007-08-30
发明人： BENCO, John , BODEN, Mark , BRITO, Shaina , NAIMARK, Wendy , PHAM, Lan
CPC分类号： A61L31/148 , A61L27/227 , A61L27/34 , A61L27/50 , A61L27/54 , A61L27/58 , A61L31/047 , A61L31/10 , A61L31/14 , A61L31/16 , A61L2300/25 , A61L2300/252 , A61L2300/608
摘要： A medical device having a coating of cell adhesion polypeptides to enhance endothelial cell adhesion onto the medical device. The cell adhesion polypeptides may be any of the proteins of the extracellular matrix which are known to play a role in cell adhesion or derivative peptides such as RGD or YlGSR. The polypeptides may be incorporated into the backbone of polymer such as polyurethane, or grafted onto a polymer such polybisphosphonate. The polypeptides may also be carried on antibodies or displayed on bacteriophages. The polypeptides may also be modified to have adhesive amino acid sequences. In certain embodiments, the medical device further comprises a temporary barrier that protects the polypeptides from biofouling. The temporary barrier may be formed of a biodegradable polymer and be constructed as a coating over the polypeptides or as a plurality o micelles encapsulating the polypeptides. In certain embodiments, the polypeptides may be coated onto the medical device in such a manner as to form a monolayer of the polypeptides.
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7.发明授权MEDICAL DEVICES HAVING POLYMERIC REGIONS BASED ON STYRENE-ISOBUTYLENE COPOLYMERS 有权维生素VORRICHTUNGEN MIT POLYMERBEREICHEN AUF基于VON STYREN-ISOBUTYLEN-COPOLYMEREN
公开(公告)号：EP2114478B1
公开(公告)日：2017-04-12
申请号：EP08726087.3
申请日：2008-02-26
发明人： LINDQUIST, Jeffrey, S. , STRICKLER, Frederick, H. , BODEN, Mark , SEPPALA, Jan , MILLER, Paul, J.
CPC分类号： A61L31/048 , A61L27/16 , A61L27/34 , A61L29/041 , A61L29/085 , A61L31/10 , C08L53/02
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公开(公告)号：EP2054095B1
公开(公告)日：2016-08-24
申请号：EP07811544.1
申请日：2007-08-24
CPC分类号： A61L27/16 , A61L29/041 , A61L31/048 , C08L53/00
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