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1.发明授权MEDICAL DEVICES HAVING POROUS REGIONS FOR CONTROLLED THERAPEUTIC AGENT EXPOSURE OR DELIVERY 有权多孔地区的医疗设备对于控制悬挂或给药治疗物质的
公开(公告)号：EP2089070B1
公开(公告)日：2012-04-25
申请号：EP07839083.8
申请日：2007-10-01
发明人： TENNEY, Barron , HELMUS, Michael, N. , XU, Yixin
CPC分类号： A61M25/00 , A61F2250/0068 , A61L27/54 , A61L27/56 , A61L29/146 , A61L29/16 , A61L31/146 , A61L31/16 , A61L2300/602 , A61M31/002 , A61M37/00 , A61M2025/0057
摘要： According to an aspect of the invention, implantable or insertable medical devices are provided which contain the following: (a) one or more porous regions comprising pores and (b) one or more therapeutic agents which are (i) contained within the porous region, (ii) disposed beneath the porous region, or (iii) both. Moreover, the porous regions are capable of undergoing a change in configuration, such that the pores undergo a change in configuration, upon subjecting the porous regions to activating stimuli.
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公开(公告)号：EP2097049A1
公开(公告)日：2009-09-09
申请号：EP07864217.0
申请日：2007-11-09
发明人： XU, Yixin , SCHEUERMANN, Torsten , WEBER, Jan
IPC分类号： A61F2/82
CPC分类号： C23C14/12 , A61F2/91 , A61F2250/0035 , A61F2250/0068 , A61L31/082 , A61L31/10 , A61L31/16 , A61L2300/00 , A61L2300/608 , A61L2420/08 , C23C14/06 , C23C14/28
摘要： An endoprosthesis such as a coronary stent includes a polymeric reservoir of drug and an over coating formed of ceramic or metal for controlling elution of drug from the reservoir.
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公开(公告)号：EP2120787A1
公开(公告)日：2009-11-25
申请号：EP08726181.4
申请日：2008-02-27
发明人： HELMUS, Michael, N. , TENNEY, Barron , XU, Yixin , ALVES, Kevin, M. , STRICKLER, Frederick, H. , MILLER, Kathleen, M. , BODEN, Mark
CPC分类号： A61F2/07 , A61F2/06 , A61F2/915 , A61F2002/009 , A61F2002/072 , A61F2002/075 , A61F2250/0024 , A61L27/427 , A61L27/56 , A61L31/128 , A61L31/146
摘要： According to an aspect of the present invention, long term medical articles are provided which include the following: (a) first and second body contacting (e.g., tissue and/or body-fluid contacting) porous polymeric layers; (b) a polymeric barrier layer disposed between the first and second porous polymer layers; and (c) a reinforcement element. According to another aspect of the present invention, tubular medical articles for long term implantation are provided, which comprise: (a) a reinforcement element; (b) a blood contacting porous polymeric layer having a surface energy ranging between 20 and 30 dynes/cm disposed over an inner surface of the reinforcement element; and (c) an additional porous polymeric layer formed over an outer surface of the reinforcement element.
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公开(公告)号：EP1825030A1
公开(公告)日：2007-08-29
申请号：EP05817126.5
申请日：2005-11-01
发明人： XU, Yixin , HELMUS, Michael N.
CPC分类号： A61L31/10 , A61L31/082 , A61L31/16 , A61L2300/606 , A61L2420/02 , C09D5/4492 , C25D9/00 , C25D9/02 , C25D15/00
摘要： Methods and apparatuses for coating surfaces of medical devices by electroplating are disclosed. In one embodiment, the invention includes a coating method in which a mixture of a therapeutic agent, and a plating material are electroplated onto the surface of the medical device. The electroplating method may be performed at a relatively low temperature to avoid destruction of the therapeutic agent. In another embodiment, a coating method is disclosed in which the coating is formed by suspending a therapeutic agent in an electrolytic solution and electroplating a plating material onto the medical device wherein the plating material carries the supended therapeutic agent. Thus, the coating of plating material contains the suspended therapeutic agent. These methods and apparatuses are used to apply one or more coating materials, simultaneously or in sequence by varying the electroplating voltage. In certain embodiments of the invention, the coating materials include therapeutic agents and cationic drugs.
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公开(公告)号：EP2214743A2
公开(公告)日：2010-08-11
申请号：EP08843481.6
申请日：2008-10-31
发明人： KOKATE, Jaydeep Y. , RIZQ, Raed , RASSAT, Jay , SUTERMEISTER, Derek , ROBAINA, Samuel , EDELMAN, Peter , HOLMAN, Tom , KUELING, Michael , XU, Yixin
CPC分类号： A61L31/10 , A61L31/088 , A61L31/146 , A61L31/16 , A61L2300/00 , C23C14/06 , C23C14/3464
摘要： A method includes: providing a substrate, depositing a ceramic and an extractable material onto the substrate, forming a porous structure in the ceramic by removing the extractable material, and utilizing the ceramic in an endoprosthesis. An endoprosthesis, such as a stent, including a coating formed of a ceramic and an extractable material that can be removed from the coating to form voids is also disclosed.
摘要翻译： 一种方法包括：提供基底，将陶瓷和可提取材料沉积到基底上，通过除去可提取材料在陶瓷中形成多孔结构，并在内置假体中利用陶瓷。 还公开了一种内置假体，诸如支架，其包括由陶瓷形成的涂层和可从涂层去除以形成空隙的可提取材料。
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6.发明公开MEDICAL DEVICES HAVING POROUS REGIONS FOR CONTROLLED THERAPEUTIC AGENT EXPOSURE OR DELIVERY 有权多孔地区的医疗设备对于控制悬挂或给药治疗物质的
公开(公告)号：EP2089070A2
公开(公告)日：2009-08-19
申请号：EP07839083.8
申请日：2007-10-01
发明人： TENNEY, Barron , HELMUS, Michael, N. , XU, Yixin
CPC分类号： A61M25/00 , A61F2250/0068 , A61L27/54 , A61L27/56 , A61L29/146 , A61L29/16 , A61L31/146 , A61L31/16 , A61L2300/602 , A61M31/002 , A61M37/00 , A61M2025/0057
摘要： According to an aspect of the invention, implantable or insertable medical devices are provided which contain the following: (a) one or more porous regions comprising pores and (b) one or more therapeutic agents which are (i) contained within the porous region, (ii) disposed beneath the porous region, or (iii) both. Moreover, the porous regions are capable of undergoing a change in configuration, such that the pores undergo a change in configuration, upon subjecting the porous regions to activating stimuli.
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公开(公告)号：EP1539269B1
公开(公告)日：2007-02-21
申请号：EP03754476.4
申请日：2003-09-08
发明人： XU, Yixin
摘要： An implantable medical device such as a stent includes a molybdenum/rhenium alloy.
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公开(公告)号：EP1539269A2
公开(公告)日：2005-06-15
申请号：EP03754476.4
申请日：2003-09-08
发明人： XU, Yixin
摘要： An implantable medical device such as a stent includes a molybdenum/rhenium alloy.
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