-
公开(公告)号：EP3338807A1
公开(公告)日：2018-06-27
申请号：EP18156131.7
申请日：2011-08-09
申请人： Bracco Suisse SA
发明人： LAMY, Bernard , BETTINGER, Thierry , BUSSAT, Philippe , CHERKAOUI, Samir , GUILBERT-BRIGGER, Irene
IPC分类号： A61K49/22
CPC分类号： A61K49/223 , A61K38/178 , A61K49/221 , A61K49/222 , A61K49/227
摘要： Gas-filled microvesicles associated with a polypeptide comprising a sequence of amino acids, said sequence exhibiting binding affinity for selectins, particularly p-selectin. The polypeptide is associated to the microvesicle in the form of a targeting construct comprising said polypeptide covalently bound to an amphiphilic compound. The gas-filled microvesicles can be used in ultrasound imaging.
-
2.发明授权ASSEMBLY OF GAS-FILLED MICROVESICLE WITH ACTIVE COMPONENT FOR CONTRAST IMAGING 有权GAS安排与ACTIVE微泡用于填充的对比度
公开(公告)号：EP1696965B1
公开(公告)日：2014-12-10
申请号：EP04806412.5
申请日：2004-12-21
申请人： Bracco Suisse SA
发明人： SCHNEIDER, Michel , BUSSAT, Philippe , YAN, Feng , SENENTE, Anne
CPC分类号： A61K41/0028 , A61K47/6925 , A61K49/225
-
公开(公告)号：EP1966388B1
公开(公告)日：2013-08-07
申请号：EP06840164.5
申请日：2006-12-08
申请人： Bracco Suisse SA
发明人： BUSSAT, Philippe , CHERKAOUI, Samir , FAN, Hong (Helen) , LAMY, Bernard , NANJAPPAN, Palaniappa , PILLAI, Radhakrishna, K. , POCHON, Sibylle , SONG, Bo , SWENSON, Rolf, E.
CPC分类号： C07K14/00 , A61K47/544 , A61K49/223 , Y02A50/58
摘要： Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.
-
公开(公告)号：EP3969064A1
公开(公告)日：2022-03-23
申请号：EP20726105.8
申请日：2020-05-14
申请人： Bracco Suisse SA
发明人： BUSSAT, Philippe , LASSUS, Anne , BROCHOT, Jean , SCHNEIDER, Michel , YAN, Feng
IPC分类号： A61K49/22
-
公开(公告)号：EP3233136B1
公开(公告)日：2019-02-20
申请号：EP15816144.8
申请日：2015-12-17
申请人： Bracco Suisse SA
发明人： BUSSAT, Philippe , LASSUS, Anne
-
6.发明公开TARGETING CONSTRUCT COMPRISING ANTI-POLYMER ANTIBODY AND LIPOSOMES OR MICROVESICLES BINDING TO THE SAME 审中-公开靶构建具有抗 - 聚合物抗体和这种结合的脂质体或微泡
公开(公告)号：EP2346532A2
公开(公告)日：2011-07-27
申请号：EP09783808.0
申请日：2009-10-07
申请人： Bracco Suisse SA
摘要： Pharmaceutical kit comprising (i) a targeting construct which comprises a targeting ligand and an anti-polymer antibody and (ii) a polymer-containing liposome or gas-filled microvesicle capable of binding or associating to said construct. Also disclosed are methods of preparing and of administering said assembly, as well as an assembly comprising said targeting construct and said liposome or gas-filled microvesicle.
-
7.发明授权
-
公开(公告)号：EP3236999A1
公开(公告)日：2017-11-01
申请号：EP15820139.2
申请日：2015-12-21
申请人： Bracco Suisse SA
IPC分类号： A61K39/39
CPC分类号： A61K39/0005 , A61K39/39 , A61K47/6925 , A61K2039/55555 , A61K2039/577 , A61K2039/60 , A61K2039/6018
摘要： Gas-filled microvesicles comprising an antigen bound thereto and to aqueous suspensions containing said microvesicles, for use in immunomodulating formulations, in particular as a vaccine. The antigen is covalently bound to a component of the microvesicles envelope. The microvesicles of the invention, comprising a molar excess of fatty acids in the stabilizing envelope, are particularly effective in the uptake by antigen-presenting cells, in particular dendritic cells.
摘要翻译： 包含与其结合的抗原的充气微囊泡和含有所述微囊泡的水悬浮液，用于免疫调节制剂，特别是用作疫苗。 抗原共价结合到微泡包膜的成分。 包含稳定化包膜中摩尔过量的脂肪酸的本发明的微泡特别有效地摄取抗原呈递细胞，特别是树突细胞。
-
公开(公告)号：EP2934740A2
公开(公告)日：2015-10-28
申请号：EP13821088.5
申请日：2013-12-19
申请人： Bracco Suisse SA
摘要： A formulation for preparing gas-filled microvesicles which comprises a phospholipid and a mixture of saturated and unsaturated fatty acids. The gas-filled microvesicles having a stabilizing layer comprising said composition show an increased stability with respect to microvesicles containing only a saturated or an unsaturated fatty acid.
-
公开(公告)号：EP1482987B1
公开(公告)日：2014-08-13
申请号：EP03726024.7
申请日：2003-03-03
申请人： Bracco Suisse SA , Dyax Corp.
发明人： ARBOGAST, Christophe , BUSSAT, Philippe , DRANSFIELD, Daniel, T. , FAN, Hong , LINDER, Karen, E. , MARINELLI, Edmund, R. , NANJAPPAN, Palaniappa , NUNN, Adrian D. , PILLAI, Radhakrishna K. , POCHON, Sibylle , RAMALINGAM, Kondareddiar , SATO, Aaron , SHRIVASTAVA, Ajay , SONG, Bo , SWENSON, Rolf, E. , VON WRONSKI, Mathew, A. , WALKER, Sharon, Michele , YAN, Feng
-
-
-
-
-
-
-
-
-
搜索结果
25 条记录 (耗时 0.019 秒)
