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公开(公告)号：EP1482987B1
公开(公告)日：2014-08-13
申请号：EP03726024.7
申请日：2003-03-03
申请人： Bracco Suisse SA , Dyax Corp.
发明人： ARBOGAST, Christophe , BUSSAT, Philippe , DRANSFIELD, Daniel, T. , FAN, Hong , LINDER, Karen, E. , MARINELLI, Edmund, R. , NANJAPPAN, Palaniappa , NUNN, Adrian D. , PILLAI, Radhakrishna K. , POCHON, Sibylle , RAMALINGAM, Kondareddiar , SATO, Aaron , SHRIVASTAVA, Ajay , SONG, Bo , SWENSON, Rolf, E. , VON WRONSKI, Mathew, A. , WALKER, Sharon, Michele , YAN, Feng
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公开(公告)号：EP1966388B1
公开(公告)日：2013-08-07
申请号：EP06840164.5
申请日：2006-12-08
申请人： Bracco Suisse SA
发明人： BUSSAT, Philippe , CHERKAOUI, Samir , FAN, Hong (Helen) , LAMY, Bernard , NANJAPPAN, Palaniappa , PILLAI, Radhakrishna, K. , POCHON, Sibylle , SONG, Bo , SWENSON, Rolf, E.
CPC分类号： C07K14/00 , A61K47/544 , A61K49/223 , Y02A50/58
摘要： Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.
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公开(公告)号：EP1289565B1
公开(公告)日：2015-04-22
申请号：EP01944270.6
申请日：2001-06-04
申请人： Bracco Suisse SA
发明人： VON WRONSKI, Mathew A. , MARINELLI, Edmund R. , NUNN, Adrian D. , PILLAI, Radhakrishna , RAMALINGAM, Kondareddiar , TWEEDLE, Michael F. , LINDER, Karen , NANJAPPAN, Palaniappa , RAJU, Natarajan , YAN, Feng , SCHNEIDER, Michel
CPC分类号： A61K51/088 , A61K47/64 , A61K47/6925 , A61K49/006 , A61K49/0091 , A61K49/223 , A61K49/225 , A61K49/227 , B82Y5/00 , B82Y10/00 , B82Y30/00 , C07K7/06
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4.发明公开KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY 审中-公开KDR和VEGF / KDR结合肽及其用途的诊断与治疗
公开(公告)号：EP1572724A2
公开(公告)日：2005-09-14
申请号：EP03711418.8
申请日：2003-03-03
发明人： SATO, Aaron, K. , SEXTON, Daniel, J. , LADNER, Robert, C. , DRANSFIELD, Daniel, T. , SWENSON, Rolf, E. , MARINELLI, Edmund, R. , RAMALINGAM, Kondareddiar , NUNN, Adrian, D. , VON WRONSKI, Mathew, A. , SHRIVASTAVA, Ajay , POCHON, Sibylle , BUSSAT, Philippe , ARBOGAST, Christophe , PILLAI, Radhakrishna , FAN, Hong , LINDER, Karen, E. , SONG, Bo , NANJAPPAN, Palaniappa
IPC分类号： C07K7/00
CPC分类号： C07K7/08 , A61K38/00 , A61K49/223 , A61K51/088 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
摘要： The present invention provides binding polypeptides for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity ( e . g ., having a K D
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5.发明公开
公开(公告)号：EP1603935A2
公开(公告)日：2005-12-14
申请号：EP04716901.6
申请日：2004-03-03
发明人： SATO, Aaron, K. , DRANSFIELD, Daniel, T. , LADNER, Robert, C. , THOMAS, Regi , NANJAPPAN, Palaniappa
IPC分类号： C07K1/00
CPC分类号： C07K7/08 , A61K47/543 , A61K47/60 , A61K47/665 , A61K49/0043 , A61K49/0056 , A61K51/08 , B82Y5/00 , C07K14/00 , C07K14/4753
摘要： A polypeptide or multimeric polypeptide construct having the ability to bind to cMet or a complex comprising cMet and HGF, and methods for use are disclosed.
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公开(公告)号：EP1482987A1
公开(公告)日：2004-12-08
申请号：EP03726024.7
申请日：2003-03-03
发明人： ARBOGAST, Christophe , BUSSAT, Philippe , DRANSFIELD, Daniel, T. , FAN, Hang , LINDER, Karen, E. , MARINELLI, Edmund, R. , NANJAPPAN, Palaniappa , NUNN, Adrian , PILLAI, Radhakrishna , POCHON, Sibylle , RAMALINGAM, Kondareddiar , SATO, Aaron , SHRIVASTAVA, Ajay , SONG, Bo , SWENSON, Rolf, E. , VON WRONSKI, Mathew, A. , WALKER, Sharon, Michele
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications such as that shown in Figure 36.
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7.发明公开KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY 审中-公开KDR和VEGF / KDR结合肽及其诊断和治疗用途VERA诊断与治疗
公开(公告)号：EP1587944A1
公开(公告)日：2005-10-26
申请号：EP03770325.3
申请日：2003-09-11
发明人： SATO, Aaron, K. , SEXTON, Daniel, J. , DRANSFIELD, Daniel, T. , LADNER, Robert, C. , ARBOGAST, Christophe , BUSSAT, Philippe , FAN, Hong , KHURANA, Sudha , LINDER, Karen, E. , MARINELLI, Edmund, R. , NANJAPPAN, Palaniappa , NUNN, Adrian , PILLAI, Radhakrishna , POCHON, Sibylle , RAMALINGAM, Kondareddiar , SHRIVASTAVA, Ajay , SONG, Bo , SWENSON, Rolf E. , VON WRONSKI, Mathew A.
CPC分类号： A61K49/221 , A61K38/00 , A61K47/62 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
摘要： The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
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