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公开(公告)号：EP1482987A1
公开(公告)日：2004-12-08
申请号：EP03726024.7
申请日：2003-03-03
发明人： ARBOGAST, Christophe , BUSSAT, Philippe , DRANSFIELD, Daniel, T. , FAN, Hang , LINDER, Karen, E. , MARINELLI, Edmund, R. , NANJAPPAN, Palaniappa , NUNN, Adrian , PILLAI, Radhakrishna , POCHON, Sibylle , RAMALINGAM, Kondareddiar , SATO, Aaron , SHRIVASTAVA, Ajay , SONG, Bo , SWENSON, Rolf, E. , VON WRONSKI, Mathew, A. , WALKER, Sharon, Michele
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications such as that shown in Figure 36.
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2.发明公开KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY 审中-公开KDR和VEGF / KDR结合肽及其用途的诊断与治疗
公开(公告)号：EP1572724A2
公开(公告)日：2005-09-14
申请号：EP03711418.8
申请日：2003-03-03
发明人： SATO, Aaron, K. , SEXTON, Daniel, J. , LADNER, Robert, C. , DRANSFIELD, Daniel, T. , SWENSON, Rolf, E. , MARINELLI, Edmund, R. , RAMALINGAM, Kondareddiar , NUNN, Adrian, D. , VON WRONSKI, Mathew, A. , SHRIVASTAVA, Ajay , POCHON, Sibylle , BUSSAT, Philippe , ARBOGAST, Christophe , PILLAI, Radhakrishna , FAN, Hong , LINDER, Karen, E. , SONG, Bo , NANJAPPAN, Palaniappa
IPC分类号： C07K7/00
CPC分类号： C07K7/08 , A61K38/00 , A61K49/223 , A61K51/088 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
摘要： The present invention provides binding polypeptides for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity ( e . g ., having a K D
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3.发明公开KDR AND VEGF/KDR BINDING PEPTIDES AND THEIR USE IN DIAGNOSIS AND THERAPY 审中-公开KDR和VEGF / KDR结合肽及其诊断和治疗用途VERA诊断与治疗
公开(公告)号：EP1587944A1
公开(公告)日：2005-10-26
申请号：EP03770325.3
申请日：2003-09-11
发明人： SATO, Aaron, K. , SEXTON, Daniel, J. , DRANSFIELD, Daniel, T. , LADNER, Robert, C. , ARBOGAST, Christophe , BUSSAT, Philippe , FAN, Hong , KHURANA, Sudha , LINDER, Karen, E. , MARINELLI, Edmund, R. , NANJAPPAN, Palaniappa , NUNN, Adrian , PILLAI, Radhakrishna , POCHON, Sibylle , RAMALINGAM, Kondareddiar , SHRIVASTAVA, Ajay , SONG, Bo , SWENSON, Rolf E. , VON WRONSKI, Mathew A.
CPC分类号： A61K49/221 , A61K38/00 , A61K47/62 , A61K49/223 , A61K51/088 , C07K7/08 , C07K14/001 , C07K14/52 , C07K14/71 , C07K2319/00 , Y02A50/411 , Y02A50/58
摘要： The present invention provides polypeptides, peptide dimer, and multimeric complexes comprising at least one binding moiety for KDR or VEGF/KDR complex, which have a variety of uses wherever treating, detecting, isolating or localizing angiogenesis is advantageous. Particularly disclosed are synthetic, isolated polypeptides capable of binding KDR or VEGF/KDR complex with high affinity (e.g., having a KD
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公开(公告)号：EP1590006A2
公开(公告)日：2005-11-02
申请号：EP04707586.6
申请日：2004-02-03
CPC分类号： A61K49/223
摘要： Method for preparing a lyophilized matrix and, upon reconstitution of the same, a respective injectable contrast agent comprising a liquid aqueous suspension of gas-filled microbubbles stabilized predominantly by a phospholipid. The method comprises preparing an emulsion from an aqueous medium, a phospholipid and a water immiscible organic solvent. The emulsion is then freeze-dried and subsequently reconstituted in an aqueous suspension of gas-filled microbubbles. The method allows to obtain suspensions comprising microbubbles having a relatively small diameter and a narrow size distribution.
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5.发明公开TARGETING AND THERAPEUTIC COMPOUNDS AND GAS-FILLED MICROVESICLES COMPRISING SAID COMPOUNDS 审中-公开定位和治疗化合物与瓦斯这些链接的微泡填充
公开(公告)号：EP2117603A2
公开(公告)日：2009-11-18
申请号：EP07859131.0
申请日：2007-12-19
IPC分类号： A61K49/00
CPC分类号： A61K49/223
摘要： New targeting or therapeutic compounds which can be incorporated into a composition of gas-filled microvesicles. The invention further relates to gas-filled microvesicles for diagnostic and/or therapeutic use comprising said compounds and to their method of use. The new compounds are compounds of formula M-S-T, wherein : M represents a component capable of associating with an envelope of a gas-filled microvesicle; T represents a component comprising a targeting ligand or a therapeutic agent; and S represents a component comprising at least two bissulfone groups.
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公开(公告)号：EP1966388A2
公开(公告)日：2008-09-10
申请号：EP06840164.5
申请日：2006-12-08
发明人： BUSSAT, Philippe , CHERKAOUI, Samir , FAN, Hong (Helen) , LAMY, Bernard , NANJAPPAN, Palaniappa , PILLAI, Radhakrishna, K. , POCHON, Sibylle , SONG, Bo , SWENSON, Rolf, E.
CPC分类号： C07K14/00 , A61K47/544 , A61K49/223 , Y02A50/58
摘要： Peptide vectors having high KDR binding affinity and processes for making such vectors are provided. The peptide vectors may be conjugated to phospholipids and included in ultrasound contrast agent compositions. Such ultrasound contrast agents are particularly useful in therapeutic and diagnostic methods, such as in imaging KDR-containing tissue and in the evaluation and treatment of angiogenic processes associated with neoplastic conditions. The present invention also provides processes for the large scale production of highly pure dimeric and monomeric peptide phospholipid conjugates as well as precursor materials used to form the conjugates. The present invention further provides processes for the large scale production of highly pure peptide phospholipid conjugates which contain very low levels of TFA.
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公开(公告)号：EP0474833B2
公开(公告)日：2004-08-11
申请号：EP91907163.9
申请日：1991-04-02
CPC分类号： A61K49/223 , A61K49/227 , Y10S514/975
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公开(公告)号：EP1587523A2
公开(公告)日：2005-10-26
申请号：EP03815479.5
申请日：2003-09-11
发明人： ARBOGAST, Christophe , BUSSAT, Philippe , DRANSFIELD, Daniel, T. , FAN, Hong , LINDER, Karen , MARINELLI, Edmund, R. , NANJAPPAN, Palaniappa , NUNN, Adrian , PILLAI, Radhakrishna , POCHON, Sybille , RAMALINGAM, Kondareddiar , SATO, Aaron , SHRIVASTAVA, Ajay , SONG, Bo , SWENSON, Rolf, E. , VON WRONSKI, Mathew, A. , WALKER, Sharon, Michele
摘要： The invention provides compositions and methods for therapeutic and diagnostic applications.
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公开(公告)号：EP0474833B1
公开(公告)日：1995-08-02
申请号：EP91907163.9
申请日：1991-04-02
CPC分类号： A61K49/223 , A61K49/227 , Y10S514/975
摘要： Gas or air filled microbubble suspensions in aqueous phases usable as imaging contrast agents in ultrasonic echography. They contain laminarized surfactants and, optionally, hydrophilic stabilizers. The laminarized surfactants can be in the form of liposomes. The suspensions are obtained by exposing the laminarized surfactants to air or a gas before or after admixing with an aqueous phase.
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公开(公告)号：EP1482987B1
公开(公告)日：2014-08-13
申请号：EP03726024.7
申请日：2003-03-03
申请人： Bracco Suisse SA , Dyax Corp.
发明人： ARBOGAST, Christophe , BUSSAT, Philippe , DRANSFIELD, Daniel, T. , FAN, Hong , LINDER, Karen, E. , MARINELLI, Edmund, R. , NANJAPPAN, Palaniappa , NUNN, Adrian D. , PILLAI, Radhakrishna K. , POCHON, Sibylle , RAMALINGAM, Kondareddiar , SATO, Aaron , SHRIVASTAVA, Ajay , SONG, Bo , SWENSON, Rolf, E. , VON WRONSKI, Mathew, A. , WALKER, Sharon, Michele , YAN, Feng
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