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公开(公告)号：EP1610780B1
公开(公告)日：2010-04-21
申请号：EP04758053.5
申请日：2004-03-23
发明人： DAS, Jagabandhu , PADMANABHA, Ramesh , CHEN, Ping , NORRIS, Derek, J. , DOWEYKO, Arthur, M. P. , BARRISH, Joel , WITYAK, John , LOMBARDO, Louis, J. , LEE, Francis, Y. F.
IPC分类号： A61K31/427 , A61K31/506 , A61P35/02
CPC分类号： A61K31/427 , A61K31/506 , C07C237/40 , C07D213/81 , C07D213/82 , C07D231/38 , C07D233/90 , C07D239/42 , C07D263/48 , C07D277/56 , C07D409/12 , C07D417/12 , C07D417/14
摘要： Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
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2.发明授权METHODS OF TREATING P38 KINASE-ASSOCIATED CONDITIONS AND PYRROLOTRIAZINE COMPOUNDS USEFUL AS KINASE INHIBITORS 有权治疗与p38激酶和吡咯并三嗪化合物作为激酶抑制剂相关的病症的方法。
公开(公告)号：EP1363910B1
公开(公告)日：2006-03-01
申请号：EP01992298.8
申请日：2001-11-07
IPC分类号： C07D487/04 , C07D519/00 , A61K31/53 , A61P29/00 , C07D253/00 , C07D209/00 , C07D487/00 , C07D471/00
CPC分类号： C07D487/04
摘要： Methods of treating one or more conditions associated with p38 kinase activity are disclosed comprising administering to a patient in need thereof at least one compound having the formula (I): or a pharmaceutically acceptable salt, prodrug, or solvate thereof, wherein R3 is hydrogen, methyl, perfluoromethyl, methoxy, halogen, cyano, or NH2, preferably methyl, and X, R1 through R6, and Z are as described in the specification. Advantageously the groups ZR4R5 taken together comprise an NH-subsituted aryl.
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公开(公告)号：EP1610780A2
公开(公告)日：2006-01-04
申请号：EP04758053.5
申请日：2004-03-23
发明人： DAS, Jagabandhu , PADMANABHA, Ramesh , CHEN, Ping , NORRIS, Derek, J. , DOWEYKO, Arthur, M. P. , BARRISH, Joel , WITYAK, John , LOMBARDO, Louis, J. , LEE, Francis, Y. F.
IPC分类号： A61K31/427 , A61K31/506
CPC分类号： A61K31/427 , A61K31/506 , C07C237/40 , C07D213/81 , C07D213/82 , C07D231/38 , C07D233/90 , C07D239/42 , C07D263/48 , C07D277/56 , C07D409/12 , C07D417/12 , C07D417/14
摘要： Novel cyclic compounds and salts thereof, pharmaceutical compositions containing such compounds, and methods of using such compounds in the treatment of protein tyrosine kinase-associated disorders such as immunologic and oncologic disorders.
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