专利检索 ap:("Bristol-Myers Squibb Company") AND inv:"BOYLE, Alfred, W." 第 1 页

1.

发明公开
PROCESS FOR PREPARING DIDEOXYINOSINE USING ADENOSINE DEAMINASE ENZYME 审中-公开
标题翻译：用于生产双脱氧肌苷利用酶腺苷脱氨酶

公开(公告)号：EP1618204A2

公开(公告)日：2006-01-25

申请号：EP04715777.1

申请日：2004-02-27

申请人： Bristol-Myers Squibb Company

发明人： SKONEZNY, Paul, M. , POLITINO, Michael , LIU, Suo, W. , BOYLE, Alfred, W. , CHEN, Jason, G. , STEIN, Gregory, L. , FRANCESCHINI, Thomas , ANDERSON, Wendy, L.

IPC分类号： C12Q1/00

CPC分类号： C07H19/167 , C12P19/40

摘要： A method of making didanosine (ddI) including the steps of: (a) obtaining an enzyme expressing ddA deaminase activity; (b) immobilizing the enzyme onto an insoluble support; (c) contacting the enzyme with a dideoxyadenosine (ddA) solution of at least about 4% weight volume ddA in water for a time and under conditions to produce a ddI solution; and (d) isolating the ddI from the ddI solution. Optionally, the ddI mother liquor is reused in subsequent runs to improve yield.