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1.发明授权A PROCESS FOR PREPARING (2R,3S)-1,2-EPOXY-3-(PROTECTED)AMINO-4-SUBSTITUTED BUTANE AND INTERMEDIATES THEREOF 有权用于生产（2R，3S）-1,2-环氧-3-（被保护）氨基-4-取代丁烷和其中间体
公开(公告)号：EP1893765B1
公开(公告)日：2011-11-30
申请号：EP06750625.3
申请日：2006-04-19
发明人： BOWERS, Nigel, Ian , SKONEZNY, Paul, M. , STEIN, Gregory, L. , FRANCESCHINI, Thomas , CHIANG, Shu-Jen , ANDERSON, Wendy, L. , YOU, Li , XING, Zizhuo
CPC分类号： C12R1/01 , C12P13/001
摘要： The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648.
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2.发明公开A PROCESS FOR PREPARING (2R,3S)-1,2-EPOXY-3-(PROTECTED)AMINO-4-SUBSTITUTED BUTANE AND INTERMEDIATES THEREOF 有权用于生产（2R，3S）-1,2-环氧-3-（被保护）氨基-4-取代丁烷和其中间体
公开(公告)号：EP1893765A1
公开(公告)日：2008-03-05
申请号：EP06750625.3
申请日：2006-04-19
发明人： BOWERS, Nigel, Ian , SKONEZNY, Paul, M. , STEIN, Gregory, L. , FRANCESCHINI, Thomas , CHIANG, Shu-Jen , ANDERSON, Wendy, L. , YOU, Li , XING, Zizhuo
CPC分类号： C12R1/01 , C12P13/001
摘要： The present invention relates to a process for preparing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane comprising contacting a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648 with (3S)-1-halo-2-oxo-3-(protected)amino-4-substituted butane substrate. The present invention also relates to a process comprising mixing (2R,3S)-1-halo-2-hydroxy-3-(protected)amino-4-substituted butane with at least one base in the presence of at least one solvent to produce a reaction mixture containing (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane. The present invention further relates to a process comprising crystallizing the (2R,3S)-1,2-epoxy-3-(protected)amino-4-substituted butane out of the reaction mixture by concurrently adding water and the reaction mixture together. The present invention is also directed to a mutagenized Rhodococcus erythropolis having ATCC deposit no. PTA-6648.
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3.发明公开
公开(公告)号：EP1618204A2
公开(公告)日：2006-01-25
申请号：EP04715777.1
申请日：2004-02-27
发明人： SKONEZNY, Paul, M. , POLITINO, Michael , LIU, Suo, W. , BOYLE, Alfred, W. , CHEN, Jason, G. , STEIN, Gregory, L. , FRANCESCHINI, Thomas , ANDERSON, Wendy, L.
IPC分类号： C12Q1/00
CPC分类号： C07H19/167 , C12P19/40
摘要： A method of making didanosine (ddI) including the steps of: (a) obtaining an enzyme expressing ddA deaminase activity; (b) immobilizing the enzyme onto an insoluble support; (c) contacting the enzyme with a dideoxyadenosine (ddA) solution of at least about 4% weight volume ddA in water for a time and under conditions to produce a ddI solution; and (d) isolating the ddI from the ddI solution. Optionally, the ddI mother liquor is reused in subsequent runs to improve yield.
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