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公开(公告)号：EP1539766B1
公开(公告)日：2016-12-21
申请号：EP03736721.6
申请日：2003-05-27
发明人： CHATURVEDULA, Prasad, V. , CHEN, Ling , CIVIELLO, Rita , CONWAY, Charles, Mark , DEGNAN, Andrew, P. , DUBOWCHIK, Gene, M. , HAN, Xiaojun , KARAGEORGE, George, N. , LUO, Guanglin , MACOR, John, E. , POINDEXTER, Graham , VIG, Shikha
IPC分类号： C07D487/14 , C07D487/22 , A61K31/517 , A61K31/496 , A61K31/4427 , A61P11/00 , A61P11/06 , A61P25/06 , C07D487/04
CPC分类号： A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/106 , A01K2267/0306 , A61K49/0008 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/10 , C07D487/04 , C07D487/14 , C07D491/10 , C12N15/8509 , G01N33/566 , G01N2500/10 , G01N2800/2807
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公开(公告)号：EP1539766A1
公开(公告)日：2005-06-15
申请号：EP03736721.6
申请日：2003-05-27
发明人： CHATURVEDULA, Prasad, V. , CHEN, Ling , CIVIELLO, Rita , CONWAY, Charles, Mark , DEGNAN, Andrew, P. , DUBOWCHIK, Gene, M. , HAN, Xiaojun , KARAGEORGE, George, N. , LUO, Guanglin , MACOR, John, E. , POINDEXTER, Graham , VIG, Shikha
IPC分类号： C07D487/14 , C07D487/22 , A61K31/517 , A61K31/496 , A61K31/4427 , A61P11/00 , A61P11/06 , A61P25/06
CPC分类号： A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/106 , A01K2267/0306 , A61K49/0008 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/10 , C07D487/04 , C07D487/14 , C07D491/10 , C12N15/8509 , G01N33/566 , G01N2500/10 , G01N2800/2807
摘要： The presnt invention relates to compounds of Formula (I), as antagonists of calcitonin gene-related peptide receptors ("CGRP-receptor"), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
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