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公开(公告)号：EP1730137A1
公开(公告)日：2006-12-13
申请号：EP05731205.0
申请日：2005-03-28
IPC分类号： C07D401/14 , A61K31/444 , A61P25/06
CPC分类号： C07D401/14
摘要： The present invention relates to compounds of Formula (I) as antagonists of calcitonin gene-related peptide receptors (“CGRP-receptor”), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
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公开(公告)号：EP3580232A1
公开(公告)日：2019-12-18
申请号：EP18708002.3
申请日：2018-02-08
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公开(公告)号：EP1539766B1
公开(公告)日：2016-12-21
申请号：EP03736721.6
申请日：2003-05-27
发明人： CHATURVEDULA, Prasad, V. , CHEN, Ling , CIVIELLO, Rita , CONWAY, Charles, Mark , DEGNAN, Andrew, P. , DUBOWCHIK, Gene, M. , HAN, Xiaojun , KARAGEORGE, George, N. , LUO, Guanglin , MACOR, John, E. , POINDEXTER, Graham , VIG, Shikha
IPC分类号： C07D487/14 , C07D487/22 , A61K31/517 , A61K31/496 , A61K31/4427 , A61P11/00 , A61P11/06 , A61P25/06 , C07D487/04
CPC分类号： A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/106 , A01K2267/0306 , A61K49/0008 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/10 , C07D487/04 , C07D487/14 , C07D491/10 , C12N15/8509 , G01N33/566 , G01N2500/10 , G01N2800/2807
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公开(公告)号：EP2013214A2
公开(公告)日：2009-01-14
申请号：EP07761726.4
申请日：2007-05-02
发明人： CHATURVEDULA, Prasad V. , MERCER, Stephen E. , FANG, Haiquan , HAN, Xiaojun , LUO, Guanglin , DUBOWCHIK, Gene M. , POINDEXTER, Graham S.
IPC分类号： C07D487/04 , C07D519/00 , A61K31/55 , A61P25/06
CPC分类号： C07D487/04
摘要： The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors. Formule I and II
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公开(公告)号：EP1539766A1
公开(公告)日：2005-06-15
申请号：EP03736721.6
申请日：2003-05-27
发明人： CHATURVEDULA, Prasad, V. , CHEN, Ling , CIVIELLO, Rita , CONWAY, Charles, Mark , DEGNAN, Andrew, P. , DUBOWCHIK, Gene, M. , HAN, Xiaojun , KARAGEORGE, George, N. , LUO, Guanglin , MACOR, John, E. , POINDEXTER, Graham , VIG, Shikha
IPC分类号： C07D487/14 , C07D487/22 , A61K31/517 , A61K31/496 , A61K31/4427 , A61P11/00 , A61P11/06 , A61P25/06
CPC分类号： A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2227/106 , A01K2267/0306 , A61K49/0008 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/10 , C07D487/04 , C07D487/14 , C07D491/10 , C12N15/8509 , G01N33/566 , G01N2500/10 , G01N2800/2807
摘要： The presnt invention relates to compounds of Formula (I), as antagonists of calcitonin gene-related peptide receptors ("CGRP-receptor"), pharmaceutical compositions comprising them, methods for identifying them, methods of treatment using them and their use in therapy for treatment of neurogenic vasodilation, neurogenic inflammation, migraine and other headaches, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.
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6.发明公开IMIDAZOLYL DERIVATIVES AS CORTICOTROPIN RELEASING FACTOR INHIBITORS 审中-公开IMIDAZOLYLDERIVATIVE AS促肾上腺皮质激素释放因子抑制剂
公开(公告)号：EP1359916A1
公开(公告)日：2003-11-12
申请号：EP02705754.6
申请日：2002-01-11
发明人： DUBOWCHIK, Gene, M. , HAN, Xiaojun , VRUDHULA, Vivekananda, M. , ZUEV, Dmitry , DASGUPTA, Bireshwar , MICHNE, Jodi, A.
IPC分类号： A61K31/53 , A61K31/519 , A61K31/445 , A61K31/41 , A61K31/415 , A61P25/00 , C07D487/00 , C07D401/00 , C07D249/00 , C07D235/02 , C07D403/02
CPC分类号： C07D471/14 , C07D487/04
摘要： The present invention relates to novel heterocyclic antagonists of Formula I and pharmaceutical compositions comprising said antagonists of the coticotropin releasing factor receptor ('CRF receptor') (formula), useful for the treatment of depression, anxiety, affective disorders, feeding disorders, post-traumatic stress disorder, headache, drug addiction, inflammatory disorders, drug or alcohol withdrawal symptoms and other conditions the treatment of which can be effected by the antagonism of the CRF-1 receptor.
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公开(公告)号：EP2013214B1
公开(公告)日：2015-06-24
申请号：EP07761726.4
申请日：2007-05-02
发明人： CHATURVEDULA, Prasad V. , MERCER, Stephen E. , FANG, Haiquan , HAN, Xiaojun , LUO, Guanglin , DUBOWCHIK, Gene M. , POINDEXTER, Graham S.
IPC分类号： C07D487/04 , C07D519/00 , A61K31/55 , A61P25/06
CPC分类号： C07D487/04
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