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1.发明公开PYRROLINONE CARBOXAMIDE COMPOUNDS USEFUL AS ENDOTHELIAL LIPASE INHIBITORS 有权Pyrrolinones甲酰胺衍生物作为ENDOTHELLIPASE抑制剂的
公开(公告)号：EP2760830A1
公开(公告)日：2014-08-06
申请号：EP12770383.3
申请日：2012-09-24
发明人： QIAO, Jennifer, X. , FINLAY, Heather , JIANG, Ji , LLOYD, John , HU, Carol Hui , PI, Zulan , TORA, George, O. , NEELS, James , HANGELAND, Jon, J. , FRIENDS, Todd, J.
IPC分类号： C07D207/38 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , A61K31/4015 , A61P3/06
CPC分类号： C07D207/38 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07F7/0812
摘要： The present invention provides compounds of Formula (I): (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
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2.发明授权PYRROLINONE CARBOXAMIDE COMPOUNDS USEFUL AS ENDOTHELIAL LIPASE INHIBITORS 有权Pyrrolinones甲酰胺衍生物作为ENDOTHELLIPASE抑制剂的
公开(公告)号：EP2760830B1
公开(公告)日：2016-08-03
申请号：EP12770383.3
申请日：2012-09-24
发明人： QIAO, Jennifer, X. , FINLAY, Heather , JIANG, Ji , LLOYD, John , HU, Carol Hui , PI, Zulan , TORA, George, O. , NEELS, James , HANGELAND, Jon, J. , FRIENDS, Todd, J.
IPC分类号： C07D207/38 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , A61K31/4015 , A61P3/06
CPC分类号： C07D207/38 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07F7/0812
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3.发明公开TETRAHYDROQUINOLINE DERIVATIVES USEFUL AS SERINE PROTEASE INHIBITORS 审中-公开AS APPROPRIATE丝氨酸蛋白酶抑制剂的四氢喹啉
公开(公告)号：EP1601656A1
公开(公告)日：2005-12-07
申请号：EP04719245.5
申请日：2004-03-10
发明人： QUAN, Mimi, L. , WANG, Cailan , ZHOU, Jinglan , HANGELAND, Jon, J. , SEIFFERT, Dietmar, A. , KNABB, Robert, M.
IPC分类号： C07D217/02 , C07D217/12 , A61K31/47
CPC分类号： C07D401/12 , C07D215/12 , C07D215/20 , C07D215/48
摘要： The present invention provides compounds of Formula (I) ; or a stereoisomer or pharmaceutically acceptable salt form thereof, wherein the variables A, B, L1, L2, X1, X2, X3, X4, R4, R5, R13, R14, R15 and R16 are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
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