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公开(公告)号：EP2870153B1
公开(公告)日：2016-11-02
申请号：EP13737779.2
申请日：2013-07-08
发明人： JOHNSON, James A. , JIANG, Ji , KIM, Soong-Hoon , PI, Zulan , QIAO, Jennifer X. , TORA, George O. , WANG, Tammy C. , FINLAY, Heather
IPC分类号： C07D417/06 , C07D417/14 , A61K31/54 , A61P9/00 , A61P9/10 , A61K31/428
CPC分类号： C07D417/06 , C07D417/14
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公开(公告)号：EP1954668B9
公开(公告)日：2012-03-21
申请号：EP06839913.8
申请日：2006-11-16
发明人： SALVATI, Mark E. , FINLAY, Heather , CHEN, Bang-chi , HARIKRISHNAN, Lalgudi S. , JIANG, Ji , JOHNSON, James A. , KAMAU, Muthoni G. , LAWRENCE, Michael R. , LI, Jianqing , LLOYD, John , MILLER, Michael Matthew , PI, Zulan , QIAO, Jennifer X. , RAMPULLA, Richard , WANG, Tammy C. , WANG, Yufeng , YANG, Wu , ROBERGE, Jacques Y.
IPC分类号： C07C211/29 , C07C215/08 , C07C217/58 , C07C229/36 , C07C229/38 , C07C233/09 , C07C233/13 , C07C233/18 , C07C233/56 , C07C233/60 , C07C233/66 , C07C233/73 , C07C233/78 , C07C235/20 , C07C235/34
CPC分类号： C07C275/26 , C07C211/29 , C07C215/08 , C07C217/58 , C07C229/36 , C07C229/38 , C07C233/09 , C07C233/13 , C07C233/18 , C07C233/56 , C07C233/60 , C07C233/66 , C07C233/73 , C07C233/78 , C07C235/20 , C07C235/34 , C07C235/48 , C07C235/74 , C07C237/06 , C07C237/08 , C07C251/38 , C07C255/13 , C07C255/57 , C07C255/60 , C07C271/16 , C07C271/20 , C07C271/44 , C07C275/24 , C07C311/04 , C07C311/17 , C07C317/44 , C07C323/57 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D205/08 , C07D207/10 , C07D207/16 , C07D207/26 , C07D207/273 , C07D207/325 , C07D207/38 , C07D209/18 , C07D209/20 , C07D209/42 , C07D209/48 , C07D211/38 , C07D211/58 , C07D213/38 , C07D213/40 , C07D213/82 , C07D231/14 , C07D231/40 , C07D239/26 , C07D249/04 , C07D249/06 , C07D249/08 , C07D249/14 , C07D257/04 , C07D257/06 , C07D261/04 , C07D261/08 , C07D261/14 , C07D261/18 , C07D263/34 , C07D271/06 , C07D271/10 , C07D271/113 , C07D277/48 , C07D277/58 , C07D277/60 , C07D285/06 , C07D285/135 , C07D295/155 , C07D303/48 , C07D307/22 , C07D307/24 , C07D307/33 , C07D307/68 , C07D307/79 , C07D307/85 , C07D311/58 , C07D317/46 , C07D319/20 , C07D333/20 , C07D333/24 , C07D333/38 , C07D333/68 , C07D333/70 , C07D471/04 , C07F7/0818
摘要： Compounds of formula (Ia) and (Ib) wherein A, B, C and R1 are described herein. The compounds (Ia) and (Ib) are useful as CETP inhibitors.
摘要翻译： 式Ia和Ib worin A，B，C和R1的化合物被描述英寸
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公开(公告)号：EP2760834B1
公开(公告)日：2016-11-16
申请号：EP12770384.1
申请日：2012-09-24
发明人： PI, Zulan , LLOYD, John , QIAO, Jennifer X. , WANG, Tammy C. , TORA, George O.
IPC分类号： C07D213/81 , C07D213/89 , C07D401/04 , C07D401/12 , C07D413/04 , C07D213/34 , C07D409/04
CPC分类号： C07D213/81 , C07D213/34 , C07D213/89 , C07D401/04 , C07D401/12 , C07D409/04 , C07D413/04
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4.发明授权AMIDE OR UREA SUBSTITUTED BENZOTHIAZOLE DERIVATIVES AS INHIBITORS OF ENDOTHELIAL LIPASE 有权酰胺或脲取代苯并噻唑作为ENDOTHELLIPASE抑制剂的
公开(公告)号：EP2870152B1
公开(公告)日：2016-09-28
申请号：EP13737767.7
申请日：2013-07-03
发明人： PI, Zulan , QIAO, Jennifer X. , TORA, George O. , WANG, Tammy C.
IPC分类号： C07D417/06 , C07D417/14 , A61K31/428 , A61K31/4439 , A61K31/515 , A61P3/06 , A61P9/10 , A61P9/12 , A61P25/28
CPC分类号： C07D417/14 , C07D417/06
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5.发明公开PYRROLINONE CARBOXAMIDE COMPOUNDS USEFUL AS ENDOTHELIAL LIPASE INHIBITORS 有权Pyrrolinones甲酰胺衍生物作为ENDOTHELLIPASE抑制剂的
公开(公告)号：EP2760830A1
公开(公告)日：2014-08-06
申请号：EP12770383.3
申请日：2012-09-24
发明人： QIAO, Jennifer, X. , FINLAY, Heather , JIANG, Ji , LLOYD, John , HU, Carol Hui , PI, Zulan , TORA, George, O. , NEELS, James , HANGELAND, Jon, J. , FRIENDS, Todd, J.
IPC分类号： C07D207/38 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , A61K31/4015 , A61P3/06
CPC分类号： C07D207/38 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07F7/0812
摘要： The present invention provides compounds of Formula (I): (I), as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
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6.发明授权2-PHENOXY-N-(1,3,4-THIADIZOL-2-YL)PYRIDIN-3-AMINE DERIVATIVES AND RELATED COMPOUNDS AS P2Y1 RECEPTOR INHIBITORS FOR THE TREATMENT OF THROMBOEMBOLIC DISORDERS 有权2-苯氧基 - N-（1,3,4- THIADIZOL -2-基）吡啶-3-胺衍生物和相关化合物P2Y1受体抑制剂用于治疗血栓栓塞性病症
公开(公告)号：EP1954696B1
公开(公告)日：2011-02-23
申请号：EP06733718.8
申请日：2006-01-17
发明人： SUTTON, James, C. , PI, Zulan , RUEL, Rejean , L'HEUREUX, Alexandre , THIBEAULT, Carl , LAM, Patrick, Y., S.
IPC分类号： C07D417/12 , C07D413/12 , C07D401/12 , C07D213/74 , C07D417/14 , C07D277/42 , C07D277/56 , C07D513/04 , A61P7/02
CPC分类号： C07D213/74 , C07D213/75 , C07D213/80 , C07D277/42 , C07D277/56 , C07D401/12 , C07D401/14 , C07D405/14 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D487/04 , C07D513/04
摘要： The present invention provides novel heteroaryl compounds of formula (Ia) which are selective inhibitors of the human P2Y1 receptor. The invention also provides for various pharmaceutical compositions of the same and methods for treating diseases responsive to modulation of P2Y1 receptor activity. (Ia) or a stereoisomer, tautomer, pharmaceutically acceptable salt, or solvate thereof, wherein: ring A is a 5- to 6-membered heteroaryl comprising: carbon atoms and 1-4 ringheteroatoms selected from N, NR11, S(O)p, and O, wherein said heteroaryl is substituted with 0-4 R1; ring B is phenyl substituted with 0-4 R7, pyridyl substituted with 0-3 R7, or thienyi substituted with 0-2 R7; X is NH or NMe; Y is O or S; R5 is a -(CRfRf)n-C3-10 carbocycle substituted with 1-4 R5a, or a -(CRfRf)n-5- to 10-membered heterocycle comprising: carbon atoms and 1-4 heteroatoms selected from N, NR11, O, and S(O)p, wherein said heterocycle is substituted with 0-4 R5a; the other substituents and variables are defined in the claims.
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公开(公告)号：EP3390400A1
公开(公告)日：2018-10-24
申请号：EP16820507.8
申请日：2016-12-15
发明人： MYERS, Michael C. , LAWRENCE, R. Michael , BILDER, Donna M. , MENG, Wei , PI, Zulan , BRIGANCE, Robert Paul , FINLAY, Heather
IPC分类号： C07D413/14 , C07D403/04 , C07D413/04 , C07D417/14 , A61K31/513 , A61P9/00
CPC分类号： C07D403/04 , C07D413/04 , C07D413/14 , C07D417/14
摘要： The present invention provides compounds of Formula (I): wherein all variables are as defined in the specification, and compositions comprising any of such novel compounds. These compounds are APJ agonists which may be used as medicaments, in particular for treating cardiovascular disorders.
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8.发明授权AMIDE, UREA OR SULFONE AMIDE LINKED BENZOTHIAZOLE INHIBITORS OF ENDOTHELIAL LIPASE 有权酰胺，尿素或磺酰胺连接的苯并噻唑抑制剂的内皮脂肪酶
公开(公告)号：EP2875007B1
公开(公告)日：2016-08-24
申请号：EP13742364.6
申请日：2013-07-18
发明人： FINLAY, Heather , JIANG, Ji , KIM, Soong-Hoon , PARKHURST, Brandon , QIAO, Jennifer X. , WANG, Tammy C. , PI, Zulan , TORA, George O. , LLOYD, John , JOHNSON, James A.
IPC分类号： C07D277/64 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14 , A61K31/428 , A61P9/10
CPC分类号： C07D277/64 , C07D417/04 , C07D417/10 , C07D417/12 , C07D417/14
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公开(公告)号：EP2870153A1
公开(公告)日：2015-05-13
申请号：EP13737779.2
申请日：2013-07-08
发明人： JOHNSON, James A. , JIANG, Ji , KIM, Soong-Hoon , PI, Zulan , QIAO, Jennifer X. , TORA, George O. , WANG, Tammy C. , FINLAY, Heather
IPC分类号： C07D417/06 , C07D417/14 , A61K31/54 , A61P9/00 , A61P9/10 , A61K31/428
CPC分类号： C07D417/06 , C07D417/14
摘要： The present invention provides compounds of Formula (I) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
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10.发明公开PYRROLINONE CARBOXAMIDE COMPOUNDS USEFUL AS ENDOTHELIAL LIPASE INHIBITORS 有权吡咯啉羧酰胺衍生物AS ENDOTHELLIPASE抑制剂的
公开(公告)号：EP2760829A1
公开(公告)日：2014-08-06
申请号：EP12775091.7
申请日：2012-09-25
发明人： ABELL, Lynn , ADAM, Leonard , CAVALLARO, Cullen L. , FINLAY, Heather , FRIENDS, Todd J. , HANGELAND, Jon J. , JIANG, Ji , LAWRENCE, R. Michael , LLOYD, John , PI, Zulan , TORA, George O. , QIAO, Jennifer X. , HU, Carol Hui , WANG, Tammy C.
IPC分类号： C07D207/28 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D417/04 , C07D417/06 , C07D471/04 , A61K31/4015 , A61P3/06
CPC分类号： C07D471/04 , C07D207/28 , C07D207/38 , C07D401/06 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D405/12 , C07D413/06 , C07D417/04 , C07D417/06 , C07D417/12 , C07D487/04
摘要： The present invention provides compounds of Formula (I) or Formula (III): [INSERT CHEMICAL STRUCTURE HERE] (I) [INSERT CHEMICAL STRUCTURE HERE] (III) as defined in the specification and compositions comprising any of such novel compounds. These compounds are endothelial lipase inhibitors which may be used as medicaments.
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