公开(公告)号：EP2379553A1

公开(公告)日：2011-10-26

申请号：EP10700643.9

申请日：2010-01-12

申请人： Bristol-Myers Squibb Company

发明人： MARCIN, Lawrence, R. ,  THOMPSON, Lorin, A., III ,  BOY, Kenneth, M. ,  GUERNON, Jason, M. ,  HIGGINS, Mendi, A. ,  SHI, Jianliang ,  WU, Yong-Jin ,  ZHANG, Yunhui ,  MACOR, John, E.

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/437 ,  A61K31/4196 ,  A61P25/28 ,  C07D417/12 ,  C07D513/10

CPC分类号： C07D487/04 ,  C07D417/12 ,  C07D471/04 ,  C07D513/10

摘要： The present disclosure provides a series of compounds of the formula (I) which reduce β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production, wherein A is a five- or six-membered heteroaromatic ring containing from one to three heteroatoms independently selected from nitrogen, oxygen, and sulfur; B is selected from phenyl and pyridinyl, D is selected from (II) E is selected from Ci-ealkyl, d-ecycloalkyl, benzyl, phenyl, and a five- to six- membered heteroaromatic ring containing one or two nitrogen atoms.