公开(公告)号：EP1629000B1

公开(公告)日：2009-02-18

申请号：EP04759941.0

申请日：2004-04-16

申请人： Bristol-Myers Squibb Company

发明人： MCPHEE, Fiona ,  CAMPBELL, Jeffrey Allen ,  LI, Wenying ,  D'ANDREA, Stanley ,  ZHENG, Zhizhen Barbara ,  GOOD, Andrew Charles ,  CARINI, David J. ,  JOHNSON, Barry L. ,  SCOLA, Paul Michael ,  BOY, Kenneth, M.

IPC分类号： A61K38/00 ,  C07K5/12 ,  C07K5/08 ,  A61P31/14 ,  C12P41/00

CPC分类号： C07K5/0804 ,  A61K38/00 ,  C12P7/62 ,  C12P13/04 ,  C12P41/005

摘要： Macrocyclic isoquinoline are disclosed having the general formula: A compound of formula 1: wherein R1 to R9, Q and W are described in the description. Compositions comprising the compounds and methods for using the compounds to inhibit HCV are also disclosed.

公开(公告)号：EP2379553A1

公开(公告)日：2011-10-26

申请号：EP10700643.9

申请日：2010-01-12

申请人： Bristol-Myers Squibb Company

发明人： MARCIN, Lawrence, R. ,  THOMPSON, Lorin, A., III ,  BOY, Kenneth, M. ,  GUERNON, Jason, M. ,  HIGGINS, Mendi, A. ,  SHI, Jianliang ,  WU, Yong-Jin ,  ZHANG, Yunhui ,  MACOR, John, E.

IPC分类号： C07D471/04 ,  C07D487/04 ,  A61K31/437 ,  A61K31/4196 ,  A61P25/28 ,  C07D417/12 ,  C07D513/10

CPC分类号： C07D487/04 ,  C07D417/12 ,  C07D471/04 ,  C07D513/10

摘要： The present disclosure provides a series of compounds of the formula (I) which reduce β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by β-amyloid peptide (β-AP) production, wherein A is a five- or six-membered heteroaromatic ring containing from one to three heteroatoms independently selected from nitrogen, oxygen, and sulfur; B is selected from phenyl and pyridinyl, D is selected from (II) E is selected from Ci-ealkyl, d-ecycloalkyl, benzyl, phenyl, and a five- to six- membered heteroaromatic ring containing one or two nitrogen atoms.