公开(公告)号：EP0775689A4

公开(公告)日：1999-08-11

申请号：EP95921126

申请日：1995-06-07

申请人： C & C RESEARCH LABS

发明人： CHUNG YOU ,  KIM HAK YEOP ,  JUNG KYUNG YUN ,  MIN JAE KI ,  TANABE SHIGERU

IPC分类号： C07C211/29 ,  C07C211/53 ,  C07C217/20 ,  C07C217/60 ,  C07C217/84 ,  C07C233/25 ,  C07C233/43 ,  C07C255/54 ,  C07C311/08 ,  C07D207/32 ,  C07D207/325 ,  C07D217/04 ,  C07D233/61 ,  C07D233/64 ,  C07D277/42 ,  C07D277/46 ,  C07D295/096 ,  C07D295/135 ,  C07D521/00 ,  C07C211/27 ,  C07C211/45 ,  C07C211/50 ,  C07C211/52 ,  C07C211/54 ,  C07C211/56 ,  C07C217/08 ,  C07C217/56

CPC分类号： C07D207/325 ,  C07C211/53 ,  C07C217/20 ,  C07C217/60 ,  C07C217/84 ,  C07C233/25 ,  C07C233/43 ,  C07C255/54 ,  C07C311/08 ,  C07D217/04 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D277/42 ,  C07D277/46 ,  C07D295/096 ,  C07D295/135

摘要： A novel amine derivative represented by general formula (I) and a salt thereof, each being useful as an antiarrhythmic, wherein, for example, A represents -(CH2)-O-, -(CH2)2-O- or -(CH2)2-NH-; B represents -(CH2)2-; R1 represents hydrogen, halogen, nitro, 1-pyrrolyl, acetamido, amino or dimethylamino; R2 represents hydrogen or nitro; R3 and R4 represent each hydrogen; R8a and R8b both represent chloro or methoxy at the same time; R9 represents hydrogen or amino; R represents methyl; and X represents methanesulfonamido, 1-imidazolyl or nitro.