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1.发明公开DIAGNOSIS, PREVENTION AND TREATMENT OF CROHN'S DISEASE USING THE OMPC ANTIGEN 有权诊断，预防和克罗恩氏病通过使用所述抗原OMPC处理（03年4月12日）
公开(公告)号：EP1285271A4
公开(公告)日：2003-07-23
申请号：EP01935666
申请日：2001-05-17
IPC分类号： G01N33/53 , A61K39/108 , A61P1/04 , C12N15/09 , G01N33/543 , G01N33/569 , G01N33/68 , C07H21/02 , C12Q1/68 , G01N33/564
CPC分类号： G01N33/56972 , G01N33/6854 , G01N2333/195 , G01N2333/245 , G01N2333/395 , G01N2469/20 , Y10S435/849 , Y10S435/965 , Y10S435/973 , Y10S436/811
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2.发明公开
公开(公告)号：EP0959900A4
公开(公告)日：2004-10-06
申请号：EP97924522
申请日：1997-04-11
发明人： BRAUN JONATHAN , TARGAN STEPHAN R , EGGENA MARK
IPC分类号： A61K39/00 , G01N33/564
CPC分类号： G01N33/564 , A61K39/0008
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公开(公告)号：EP2766045A4
公开(公告)日：2015-06-10
申请号：EP12840745
申请日：2012-10-15
申请人： UNIV CALIFORNIA
发明人： WADEHRA MADHURI , BRAUN JONATHAN
IPC分类号： C07K16/30 , A61K38/10 , A61K38/16 , A61K39/00 , A61K39/395 , A61K45/06 , A61K47/48 , A61K48/00 , A61P35/00
CPC分类号： A61K39/39558 , A61K38/10 , A61K45/06 , A61K2039/505 , C07K16/3015 , C07K16/3069 , C07K2317/21 , C07K2317/33 , C07K2317/34 , C07K2317/626 , C07K2317/73
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4.发明公开EPITHELIAL MEMBRANE PROTEIN 2 (EMP2) BINDING REAGENTS AND THEIR THERAPEUTIC USES IN OCULAR DISEASES 有权BINDEREAGENZIEN DES EPITHELIALMEMBRANENPROTEIN-2（EMP2）UND DEREN THERAPEUTISCHEN VERWENDUNGEN BEI AUGENKRANKHEITEN
公开(公告)号：EP2536433A4
公开(公告)日：2013-07-03
申请号：EP11745457
申请日：2011-02-22
IPC分类号： C07K16/28 , A61K31/7105 , A61K38/16 , A61K39/395 , A61P27/00 , A61P27/02 , C12N15/113
CPC分类号： C07K16/18 , A61K38/00 , C07K16/28 , C07K2317/21 , C07K2317/35 , C07K2317/76 , C12N15/1138 , C12N2310/14
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5.发明公开COMPOSITIONS AND METHODS FOR PROMOTING GROWTH OF BENEFICIAL MICROBES TO TREAT OR PREVENT DISEASE OR PROLONG LIFE 审中-公开组合物和向有益芽的对于疾病的治疗或预防或FOR延寿促进生长的方法
公开(公告)号：EP2958575A4
公开(公告)日：2016-07-27
申请号：EP14753847
申请日：2014-02-19
申请人： UNIV CALIFORNIA
发明人： YAMAMOTO MITSUKO L , SCHIESTL ROBERT H , RELIENE RAMUNE , BORNEMAN JAMES , PRESLEY LAURA L , BRAUN JONATHAN
CPC分类号： A61K35/747 , A61K35/741 , A61K35/76 , A61K45/06 , A61K2300/00
摘要： Inoculation of ATM-deficient mice with probiotic microorganisms, such as L. johnsonii, changed immune parameters, decreased a marker of DNA damage and increased the lifespan of the mice. Compositions and methods described herein are useful for the treatment and prevention of Ataxia telangiectasia and other cancer-prone diseases, such as p53 deficiency-associated cancers. Compositions and methods of the present invention are also useful for treating and preventing radiation-induced toxicity to normal tissue in a subject being exposed to radiation. Compositions and methods of the invention can increase lifespan in a simple, non-invasive manner.
摘要翻译： 用益生微生物，：如约氏乳杆菌ATM缺陷小鼠的接种，免疫改变参数，减少DNA损伤的标记物，并增加了小鼠的寿命。 组合物和所描述的方法是用于毛细血管扩张性共济失调和其它癌症倾向的疾病，：如p53缺乏相关的癌症的治疗和预防是有用的。 组合物和本发明的方法因此可用于治疗和暴露于辐射预防辐射诱发的毒性与正常组织中的受试者是有用的。 组合物和本发明的方法能够以简单的，非侵入性的方式增加寿命。
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6.发明公开EMP2 REGULATES ANGIOGENESIS IN CANCER CELLS THROUGH INDUCTION OF VEGF 审中-公开EMP2 ALS血管紧张素转换酶在KREBSZELLEN MITTELS INDUKTION VON VEGF
公开(公告)号：EP2812354A4
公开(公告)日：2016-03-09
申请号：EP13747090
申请日：2013-02-06
申请人： UNIV CALIFORNIA
发明人： WADEHRA MADHURI , BRAUN JONATHAN , GORDON LYNN K
IPC分类号： C07K16/00 , A61K39/395 , A61P35/04 , C07K16/18
CPC分类号： C07K16/30 , A61K31/69 , A61K38/14 , A61K39/39558 , A61K47/6415 , A61K2039/505 , C07K16/22 , C07K16/28 , C07K16/2857 , C07K2317/24 , C07K2317/34 , C07K2317/622
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公开(公告)号：EP2831110A4
公开(公告)日：2016-01-06
申请号：EP13770310
申请日：2013-03-14
发明人： WADEHRA MADHURI , BRAUN JONATHAN , GORDON LYNN K , LAZAR GARY S
IPC分类号： C07K16/00 , A61K39/00 , A61K39/395 , A61K45/06 , A61K47/48 , C07K16/18 , C07K16/22 , C07K16/28 , C07K16/30 , G01N33/574
CPC分类号： C07K16/18 , A61K39/39558 , A61K45/06 , A61K47/6823 , A61K47/6851 , A61K47/6855 , A61K47/6869 , A61K2039/505 , A61K2039/55 , C07K16/22 , C07K16/2863 , C07K16/30 , C07K16/3015 , C07K16/3069 , C07K2317/34 , C07K2317/626 , C07K2317/73 , C07K2317/92 , G01N33/57492 , G01N2333/4703 , G01N2333/70585 , G01N2333/70596 , G01N2333/90203 , A61K2300/00
摘要： Reduction of EMP2 expression and/or anti-EMP2 therapy reduces cancer stem cells in multiple types of cancer. For example, breast cancers stem cells were defined by the presence of HIF-1α, CD44 and ALDH. It is found that anti-EMP2 IgG1 can be used to reduce the numbers of cancer stem cells.
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8.发明公开EPITHELIAL MEMBRANE PROTEIN-2 (EMP2) AND PROLIFERATIVE VITREORETINOPATHY (PVR) 审中-公开上皮组织蛋白-2（EMP2）在增殖性维生素E（PVR）
公开(公告)号：EP2501409A4
公开(公告)日：2015-02-18
申请号：EP10832211
申请日：2010-11-18
申请人： UNIV CALIFORNIA , US GOVERNMENT
发明人： GORDON LYNN K , MORALES SHAWN A , TELANDER DAVID , BRAUN JONATHAN
IPC分类号： A61K39/395 , A61K38/16 , A61P27/00 , A61P27/02
CPC分类号： C07K16/28 , A61K9/0048 , A61K9/0051 , A61K2039/505
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9.发明公开DIAGNOSIS, PREVENTION AND TREATMENT OF ULCERATIVE COLITIS, AND CLINICAL SUBTYPES THEREOF, USING MICROBIAL UC pANCA ANTIGENS 有权诊断，预防和治疗溃疡性结肠炎及其亚型采用微生物UC PANCA抗原
公开(公告)号：EP1069907A4
公开(公告)日：2003-03-05
申请号：EP99911375
申请日：1999-03-12
申请人： UNIV CALIFORNIA
发明人： BRAUN JONATHAN , COHAVY OFFER
IPC分类号： A61K38/17 , A61P1/04 , A61P37/02 , C07K14/245 , C07K16/12 , C07K16/18 , G01N33/68 , A61K39/00 , A61K39/02 , A61K39/385 , C12Q1/18 , G01N33/564 , G01N33/569
CPC分类号： G01N33/6893 , A61K38/1709 , C07K14/245 , C07K16/1232 , C07K16/18 , G01N2800/065
摘要： The present invention relates to microbial UC pANCA antigens. The invention provides methods of diagnosing ulcerative colitis (UC) and methods of inducing tolerance in a pANCA-positive patient with UC using a histone H1-like antigen. The invention further provides methods of diagnosing UC and methods of inducing tolerance in a pANCA-positive patient with UC using a porin antigen. Methods of diagnosing UC and methods of inducing tolerance in a pANCA-positive patient with UC using a Bacteroides antigen also are provided.
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10.发明公开
公开(公告)号：EP1187591A4
公开(公告)日：2002-08-14
申请号：EP00930205
申请日：2000-04-28
申请人： UNIV CALIFORNIA
发明人： BRAUN JONATHAN , SUTTON CHRISTOPHER
IPC分类号： G01N33/53 , A61K38/00 , A61K45/00 , A61P1/04 , A61P29/00 , C07K14/195 , C07K14/33 , C07K14/35 , C07K16/12 , C12N15/09 , C12P21/08 , C12Q1/02 , A61K38/16
CPC分类号： C07K14/33 , A61K38/00 , C07K14/35 , C07K2319/00
摘要： The present invention provides nucleic acid and amino acid sequence of the novel I-1 and I-2 polypeptides, which are associated with human inflammatory bowel disease (IBD). Methods of diagnosing and treating inflammatory bowel disease using the IBD-associated I-1 and I-2 antigens also are provided.
摘要翻译： 本发明提供了新颖的I-1和I-2的多肽，其与人炎性肠疾病（IBD）相关的核酸和氨基酸序列。 因此提供了诊断和治疗用IBD相关I-1和I-2抗原炎性肠病的方法。
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