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公开(公告)号：EP0188312A3
公开(公告)日：1988-01-13
申请号：EP86300042
申请日：1986-01-06
申请人： CELLTECH LIMITED
发明人： Harris, Timothy John Roy , Docherty, Andrew James Penrose , Reynolds, John James , Murphy, Gillian
CPC分类号： C07K14/8146 , A61K38/00 , C07K2319/02
摘要： A process for producing a metalloproteinase inhibitor or a precursor thereof comprising culturing host cells transformed with a vector including a gene coding for the metalloproteinase inhibitor or the precursor and, if appropriate, cleaving the precursor to yield metalloproteinase inhibitor. The precursor may be a premetalloproteinase inhibitor or a fusion protein comprising a heterologous protein and a metalloproteinase inhibitor. The metalloproteinase inhibitor has application as the effective component in a pharmaceutical composition for the treatment of disease processes where accelerated breakdown of the extracellular organic matrix is observed.
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公开(公告)号：EP0188312A2
公开(公告)日：1986-07-23
申请号：EP86300042.8
申请日：1986-01-06
申请人： CELLTECH LIMITED
发明人： Harris, Timothy John Roy , Docherty, Andrew James Penrose , Reynolds, John James , Murphy, Gillian
CPC分类号： C07K14/8146 , A61K38/00 , C07K2319/02
摘要： A process for producing a metalloproteinase inhibitor or a precursor thereof comprising culturing host cells transformed with a vector including a gene coding for the metalloproteinase inhibitor or the precursor and, if appropriate, cleaving the precursor to yield metalloproteinase inhibitor. The precursor may be a premetalloproteinase inhibitor or a fusion protein comprising a heterologous protein and a metalloproteinase inhibitor. The metalloproteinase inhibitor has application as the effective component in a pharmaceutical composition for the treatment of disease processes where accelerated breakdown of the extracellular organic matrix is observed.
摘要翻译： 一种生产金属蛋白酶抑制剂或其前体的方法，包括用包含编码金属蛋白酶抑制剂或前体的基因的载体转化宿主细胞，如果合适的话，切割前体以产生金属蛋白酶抑制剂。 前体可以是前金属蛋白酶抑制剂或包含异源蛋白质和金属蛋白酶抑制剂的融合蛋白。 金属蛋白酶抑制剂作为治疗疾病过程的药物组合物中有效成分的应用，其中观察到细胞外有机基质的加速分解。
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