公开(公告)号：EP1692260A2

公开(公告)日：2006-08-23

申请号：EP04809857.8

申请日：2004-10-01

申请人： CENTOCOR, INC.

发明人： YAN, Li ,  HUANG, Chris ,  KESAVAN, Prabakaran ,  LI, Katherine ,  NAKADA, Marian

IPC分类号： C12N1/00

CPC分类号： C07K14/47

摘要： The invention provides isolated nucleic acids encoding a variety of nucleic acids and proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acids molecules, expression vectors containing the nucleic acids molecules of the invention, host cells into which the expression vectors have been introduced, and non- human transgenic animals in which a nucleic acids molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供了编码具有诊断，预防，治疗和其它用途的各种核酸和蛋白质的分离的核酸。 这些核酸和蛋白质可用于许多人类和其他动物疾病的诊断，预防和治疗。 本发明还提供了反义核酸分子，含有本发明的核酸分子的表达载体，导入了表达载体的宿主细胞和其中已经导入了本发明的核酸分子的非人转基因动物，或者 破坏。 本发明还提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节多种细胞过程的调节剂。

公开(公告)号：EP1617802A2

公开(公告)日：2006-01-25

申请号：EP04750883.3

申请日：2004-04-30

申请人： CENTOCOR, INC.

发明人： SONG, Xiao-yu, R. ,  HUANG, Chris ,  MA, Keying ,  LIANG, Bailin ,  NASO, Michael

IPC分类号： A61K6/00

CPC分类号： C07K14/47 ,  A61K45/06

摘要： Novel polypeptides (CNGH0010) and antibodies, including specified portions or variants, specific for at least one such CNGH0010 polypeptide, variant, or fragment thereof, as well as nucleic acids encoding such CNGH0010 polypeptides and antibodies, complementary nucleic acids, vectors, host cells, and methods of making and using thereof, are useful for therapeutic and diagnostic formulations, administration and devices. The aforesaid polypeptides can be used to generate human, primate, rodent, mammalian, chimeric, humanized and/or CDR-grafted anti-CNGH0010 antibodies. The CNGH0010 polypeptides and antibodies are used in modulating or treating at least one CNGH0010-related disease in a cell, tissue, organ, animal, or patient. Such diseases may include, but are not limited to, psoriasis, rheumatoid arthritis, emphysema, asthma, diabetes, autoimmune thyroiditis, inflammatory bowel diseases, including Crohn's disease and ulcerative colitis, different types of dermatitis including allergic dermatitis, contact dermatitis, actinic keratosis, wound healing, scar formation, various renal diseases, various respiratory diseases, various diseases of reproductive organs, such as endometriosis, melanoma, squamous cell carcinoma, ovarian cancer, breast cancer, lung cancer, colon cancer, prostate cancer, renal cell carcinoma, Grave's diseases and other inflammatory and hyperproliferative diseases.

公开(公告)号：EP1539792A2

公开(公告)日：2005-06-15

申请号：EP03762033.3

申请日：2003-06-25

申请人： Centocor, Inc.

发明人： LU, Jin ,  HUANG, Chris ,  NAKADA, Marian

IPC分类号： C07H21/04 ,  C07K14/435 ,  C07K16/00 ,  C12N1/21 ,  C12N15/63 ,  C12N5/10 ,  A61K38/17 ,  A61K31/7088 ,  A61K39/395 ,  C12P21/00

CPC分类号： C07K14/4748 ,  A61K38/00

摘要： The present invention relates to at least one novel CNGH0005 polypeptides, antibodies, including isolated nucleic acids that encode at least one CNGH0005 polypeptide or antibody, CNGH0005 vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

摘要翻译： 本发明涉及至少一种新的CNGH0005多肽，抗体，包括编码至少一种CNGH0005多肽或抗体的分离的核酸，CNGH0005载体，宿主细胞，转基因动物或植物，以及其制备和使用方法，包括治疗组合物 ，方法和设备。