公开(公告)号：EP1692260A2

公开(公告)日：2006-08-23

申请号：EP04809857.8

申请日：2004-10-01

申请人： CENTOCOR, INC.

发明人： YAN, Li ,  HUANG, Chris ,  KESAVAN, Prabakaran ,  LI, Katherine ,  NAKADA, Marian

IPC分类号： C12N1/00

CPC分类号： C07K14/47

摘要： The invention provides isolated nucleic acids encoding a variety of nucleic acids and proteins having diagnostic, preventive, therapeutic, and other uses. These nucleic acids and proteins are useful for diagnosis, prevention, and therapy of a number of human and other animal disorders. The invention also provides antisense nucleic acids molecules, expression vectors containing the nucleic acids molecules of the invention, host cells into which the expression vectors have been introduced, and non- human transgenic animals in which a nucleic acids molecule of the invention has been introduced or disrupted. The invention still further provides isolated polypeptides, fusion polypeptides, antigenic peptides and antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided. The nucleic acids and polypeptides of the present invention are useful as modulating agents in regulating a variety of cellular processes.

摘要翻译： 本发明提供了编码具有诊断，预防，治疗和其它用途的各种核酸和蛋白质的分离的核酸。 这些核酸和蛋白质可用于许多人类和其他动物疾病的诊断，预防和治疗。 本发明还提供了反义核酸分子，含有本发明的核酸分子的表达载体，导入了表达载体的宿主细胞和其中已经导入了本发明的核酸分子的非人转基因动物，或者 破坏。 本发明还提供分离的多肽，融合多肽，抗原肽和抗体。 还提供了利用本发明组合物的诊断，筛选和治疗方法。 本发明的核酸和多肽可用作调节多种细胞过程的调节剂。

公开(公告)号：EP1732599A1

公开(公告)日：2006-12-20

申请号：EP04821758.2

申请日：2004-03-25

申请人： CENTOCOR, INC.

发明人： NAKADA, Marian ,  YAN, Li ,  TANG, Yi

IPC分类号： A61K39/395

CPC分类号： C07K16/2803 ,  A61K39/39558 ,  A61K2039/505 ,  C07K14/70503 ,  C07K16/2896 ,  C07K2317/76 ,  A61K2300/00

摘要： A method of using EMMPRIN antagonists to treat pathological processes associated with proliferative diseases, such as cancer, by specifically preventing or inhibiting the ability of new tissue to develop a blood supply. The invention more specifically relates to methods of treating such diseases by the use of EMMPRIN antagonists such as antibodies directed toward EMMPRIN, including specified portions or variants, specific for at least one EMMPRIN protein or fragment thereof, in an amount effective to inhibit angiogenesis.

公开(公告)号：EP1539792A2

公开(公告)日：2005-06-15

申请号：EP03762033.3

申请日：2003-06-25

申请人： Centocor, Inc.

发明人： LU, Jin ,  HUANG, Chris ,  NAKADA, Marian

IPC分类号： C07H21/04 ,  C07K14/435 ,  C07K16/00 ,  C12N1/21 ,  C12N15/63 ,  C12N5/10 ,  A61K38/17 ,  A61K31/7088 ,  A61K39/395 ,  C12P21/00

CPC分类号： C07K14/4748 ,  A61K38/00

摘要： The present invention relates to at least one novel CNGH0005 polypeptides, antibodies, including isolated nucleic acids that encode at least one CNGH0005 polypeptide or antibody, CNGH0005 vectors, host cells, transgenic animals or plants, and methods of making and using thereof, including therapeutic compositions, methods and devices.

摘要翻译： 本发明涉及至少一种新的CNGH0005多肽，抗体，包括编码至少一种CNGH0005多肽或抗体的分离的核酸，CNGH0005载体，宿主细胞，转基因动物或植物，以及其制备和使用方法，包括治疗组合物 ，方法和设备。

公开(公告)号：EP1633309A2

公开(公告)日：2006-03-15

申请号：EP04776131.7

申请日：2004-05-27

申请人： CENTOCOR, INC.

发明人： ANDERSON, M., Glenn ,  TAWADROS, Richard ,  NGO, Cam ,  NAKADA, Marian

IPC分类号： A61K6/00

CPC分类号： C07K16/36 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/73

摘要： A method of using tissue factor antagonists to treat proliferative diseases characterized by neovascularization such as cancer, rheumatoid arthritis, psoriasis, or proliferative retinopathy. or macular degeneration. Tissue factor antagonists capable of rapid prevention of blood clotting via the extrinsic pathway are also capable of inhibiting tumor growth in mammals.