公开(公告)号：EP1390751B1

公开(公告)日：2011-11-30

申请号：EP02740818.6

申请日：2002-05-27

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE DE LILLE II

发明人： MELNYK, Oleg ,  GRAS-MASSE, Hélène ,  OLIVIER, Christophe ,  DURAND, Jean-Olivier ,  AURIAULT, Claude ,  DUBURCQ, Xavier ,  BOUZIDI, Ahmed ,  GARCIA, Jean-Michel ,  EL-MAHDI, Ouafâa

IPC分类号： G01N33/543 ,  G01N33/68

CPC分类号： G01N33/54353

摘要： The invention relates to a device for presenting peptides or proteins which can be used as a polypeptide chip for miniaturized detection of molecules which structurally or functionally complement said polypeptides. Said device consists of a flat support where polypeptides are covalently bound. The link between the polypeptides and the support results from the formation of a semicarbazone link. The semicarbazone link is a specific result of the reaction between polypeptides having an aldehyde or ketone function; and a support functionalized by semicarbazide groupings. The invention also relates to a method for preparing the supports and attaching the polypeptides to these supports in addition to the use of said devices thus obtained as polypeptide chips .

公开(公告)号：EP1487484B1

公开(公告)日：2009-02-11

申请号：EP03727589.8

申请日：2003-03-14

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) ,  UNIVERSITE DE LILLE II ,  INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

发明人： GUILLET, Jean-Gérard ,  BOURGAULT-VILLADA, Isabelle ,  DUPUIS, Marion ,  GRAS MASSE, Hélène ,  BOUREL, Line ,  MELNYK, Oleg ,  JOLY, Pascal ,  BONNET, Dominique ,  MALINGUE, Frédéric ,  GRAND JEAN, Cyrille ,  GEORGES, Bertrand

IPC分类号： A61K39/385 ,  A61K39/29 ,  A61K39/21 ,  C07K14/18 ,  A61P31/00 ,  A61P35/00

CPC分类号： C07K14/005 ,  A61K39/385 ,  A61K2039/542 ,  A61K2039/55555 ,  A61K2039/6018 ,  A61K2039/627 ,  C12N2740/15022 ,  C12N2740/16022 ,  C12N2770/24222

摘要： The invention relates to the use of a mixture containing at least lipopeptides for vaccine production. Said lipopeptides comprise a peptide compound which has been bound in solution by means of a hydrazone linkage to at least one non-peptidic lipophilic carrier. The invention also relates to native sequences NS3 of the HCV.

公开(公告)号：EP2493909B1

公开(公告)日：2014-05-21

申请号：EP10782400.5

申请日：2010-10-28

申请人： Centre National de la Recherche Scientifique (CNRS) ,  INSTITUT PASTEUR DE LILLE

发明人： MHIDIA, Reda ,  DHEUR, Julien ,  OLLIVIER, Nathalie ,  MELNYK, Oleg

IPC分类号： C07K1/02

CPC分类号： C07K1/026

公开(公告)号：EP2828279A1

公开(公告)日：2015-01-28

申请号：EP13713375.7

申请日：2013-03-18

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Institut Pasteur de Lille ,  Université de Lille 2 Droit et Santé

发明人： MELNYK, Oleg ,  RAIBAUT, Laurent ,  OLLIVIER, Nathalie

IPC分类号： C07K1/02 ,  C07K7/06 ,  C07K7/08 ,  C07D293/02 ,  C07K1/04

CPC分类号： C07K7/08 ,  C07D293/02 ,  C07D345/00 ,  C07K1/026 ,  C07K1/042 ,  C07K1/088 ,  C07K7/06 ,  C07K14/435 ,  C08F10/02 ,  C08F12/08 ,  C08F20/56 ,  C08G63/91 ,  C08G65/48 ,  C08G69/48

摘要： The present invention relates to a method for producing a polypeptide, including at least one native ligation step using a peptide functionalized with a selenium group. The invention further relates to selenium peptides and compounds.

摘要翻译： 制备多肽的方法包括使用由硒官能化的肽的至少一个天然连接步骤。 还描述了硒肽和化合物。

公开(公告)号：EP2493909A1

公开(公告)日：2012-09-05

申请号：EP10782400.5

申请日：2010-10-28

申请人： Centre National de la Recherche Scientifique CNRS ,  INSTITUT PASTEUR DE LILLE

发明人： MHIDIA, Reda ,  DHEUR, Julien ,  OLLIVIER, Nathalie ,  MELNYK, Oleg

IPC分类号： C07K1/02

CPC分类号： C07K1/026

摘要： The invention mainly relates to a method for manufacturing a polypeptide with the formula: (III) X
1 -X"-X
2 , in which X
1 and X
2 are each a peptide fragment, and X" is an amino-acid residue comprising a thiol function, said method including at least one step of reacting a ligation between a polypeptide with the formula: (I) X
1 -N(CH
2 CH
2 SH)
2 and a polypeptide with the formula: (II) H-X"-X
2 . The invention also relates to polypeptides with the formula (I) as well as to the method for obtaining same and to resin substrates suitable for obtaining same.

公开(公告)号：EP1206482B1

公开(公告)日：2003-09-24

申请号：EP00958701.5

申请日：2000-08-18

申请人： INSTITUT PASTEUR DE LILLE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： BONNET, Dominique ,  MELNYK, Oleg ,  GRAS-MASSE, Hélène

IPC分类号： C07K1/00 ,  C07K1/107

CPC分类号： C07K7/06 ,  A61K39/00 ,  C07K1/006 ,  C07K1/1075 ,  C07K1/1077 ,  C07K7/08 ,  C07K14/001

公开(公告)号：EP2828279B1

公开(公告)日：2016-03-16

申请号：EP13713375.7

申请日：2013-03-18

申请人： Centre National de la Recherche Scientifique (CNRS) ,  Institut Pasteur de Lille ,  Université de Lille 2 Droit et Santé

发明人： MELNYK, Oleg ,  RAIBAUT, Laurent ,  OLLIVIER, Nathalie

IPC分类号： C07K1/02 ,  C07K7/06 ,  C07K7/08 ,  C07D293/02 ,  C07K1/04

CPC分类号： C07K7/08 ,  C07D293/02 ,  C07D345/00 ,  C07K1/026 ,  C07K1/042 ,  C07K1/088 ,  C07K7/06 ,  C07K14/435 ,  C08F10/02 ,  C08F12/08 ,  C08F20/56 ,  C08G63/91 ,  C08G65/48 ,  C08G69/48

公开(公告)号：EP2768842A1

公开(公告)日：2014-08-27

申请号：EP12772951.5

申请日：2012-10-16

申请人： Centre National de la Recherche Scientifique (CNRS)

发明人： MELNYK, Oleg ,  RAIBAUT, Laurent ,  AUCAGNE, Vincent ,  DELMAS, Agnès

IPC分类号： C07K1/04 ,  C07K1/02 ,  C08F8/34

CPC分类号： C07K1/1077 ,  C07K1/026 ,  C07K1/04 ,  C07K1/042 ,  C07K1/045 ,  C08F8/34

摘要： The invention relates to a method for assembling proteins from peptide fragments. Said method enables the production of proteins in a simple, reliable manner that can be applied on an industrial scale. This method makes it possible to produce proteins with therapeutic or diagnostic value. The invention also relates to kits used for implementing said method for synthesizing proteins and to kits used in testing and/or diagnosis.

摘要翻译： 从肽片段组装蛋白质的方法。 它允许以简单，可靠和适用于工业规模的方式生产蛋白质。 该方法允许产生具有治疗或诊断兴趣的蛋白质。 本发明还涉及用于应用该合成方法以及测试和/或诊断试剂盒的试剂盒。

公开(公告)号：EP1315739B1

公开(公告)日：2004-08-18

申请号：EP01967454.8

申请日：2001-09-07

申请人： INSTITUT PASTEUR DE LILLE Etablissement Public ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： BONNET, Dominique ,  BOUREL, Line ,  MELNYK, Oleg ,  GRAS-MASSE, Hélène

IPC分类号： C07K1/107 ,  A61K47/48 ,  C07C233/03 ,  C07D209/32 ,  A61K39/395

CPC分类号： C07D263/04 ,  A61K38/00 ,  A61K47/54 ,  C07C235/74 ,  C07K1/1077

公开(公告)号：EP1390751A2

公开(公告)日：2004-02-25

申请号：EP02740818.6

申请日：2002-05-27

申请人： Societe d'Etude et de Developpement des Antigenes, Combinatoires - Sedac Therapeutics ,  CENTRE NATIONAL DELA RECHERCHE SCIENTIFIQUE (CNRS) ,  INSTITUT PASTEUR DE LILLE ,  UNIVERSITE DE LILLE II

发明人： MELNYK, Oleg ,  GRAS-MASSE, Hélène ,  OLIVIER, Christophe ,  DURAND, Jean-Olivier ,  AURIAULT, Claude ,  DUBURCQ, Xavier ,  BOUZIDI, Ahmed ,  GARCIA, Jean-Michel ,  EL-MAHDI, Ouafâa

IPC分类号： G01N33/543 ,  G01N33/68

CPC分类号： G01N33/54353

摘要： The invention relates to a device for presenting peptides or proteins which can be used as a polypeptide chip for miniaturized detection of molecules which structurally or functionally complement said polypeptides. Said device consists of a flat support where polypeptides are covalently bound. The link between the polypeptides and the support results from the formation of a semicarbazone link. The semicarbazone link is a specific result of the reaction between polypeptides having an aldehyde or ketone function; and a support functionalized by semicarbazide groupings. The invention also relates to a method for preparing the supports and attaching the polypeptides to these supports in addition to the use of said devices thus obtained as polypeptide chips .