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公开(公告)号：EP2767290B1
公开(公告)日：2016-09-14
申请号：EP12783080.0
申请日：2012-10-01
CPC分类号： A61K39/39 , A23K20/147 , A61K38/00 , C07K14/461
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2.发明公开COMPOUNDS ANALOGOUS TO GROWTH HORMONE PEPTIDE SECRETAGOGUES AND PREPARATIONS CONTAINING THEM 有权与生长激素肽类似物相容的化合物以及含有它们的制剂
公开(公告)号：EP1997827A1
公开(公告)日：2008-12-03
申请号：EP07711101.1
申请日：2007-02-28
发明人： RODRIGUEZ FERNANDEZ, Rolando, Eduardo , DE LA NUEZ VEULENS, Ania , ESTRADA GARCÍA, Mario, Pablo , MARTÍNEZ RODRÍGUEZ, Rebeca , CHINEA SANTIAGO, Glay , REYES ACOSTA, Osvaldo , FERNÁNDEZ MASSÓ, Julio, Raúl , GARCÍA DEL BARCO HERRERA, Diana , BERLANGA ACOSTA, Jorge, Amador , MUSACCHIO LASA, Alexis
摘要： Peptidic chemical compounds obtained by in silico molecular modelling, having a structure that enables them to perform the same functions of peptidic growth hormone secretagogues. The invention also comprises the preparations containing such compounds and the use in medicines, food additives, nutritional supplements or other formulations of human or animal use.
摘要翻译： 通过计算机模拟分子模型获得的肽化学化合物，具有使它们能够执行肽生长激素促分泌素相同功能的结构。 本发明还包括含有这些化合物的制剂以及在药物，食品添加剂，营养增补剂或其它人或动物用途制剂中的用途。
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公开(公告)号：EP2647369B1
公开(公告)日：2017-01-25
申请号：EP11807854.2
申请日：2011-11-30
发明人： ESTRADA GARCÍA, Mario, Pablo , LUGO GONZÁLEZ, Juana, María , CARPIO GONZÁLEZ, Yamila , TAFALLA PIÑEIRO, Carolina
CPC分类号： A61K38/2278 , A61K9/0019 , A61K9/0056 , A61K9/08 , A61K9/5153 , A61K31/7056 , A61K38/22 , A61K2300/00
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4.发明授权COMPOUNDS ANALOGOUS TO GROWTH HORMONE PEPTIDE SECRETAGOGUES AND PREPARATIONS CONTAINING THEM 有权与生长激素肽类似物相容的化合物以及含有它们的制剂
公开(公告)号：EP1997827B1
公开(公告)日：2013-10-09
申请号：EP07711101.1
申请日：2007-02-28
发明人： RODRIGUEZ FERNANDEZ, Rolando, Eduardo , DE LA NUEZ VEULENS, Ania , ESTRADA GARCÍA, Mario, Pablo , MARTÍNEZ RODRÍGUEZ, Rebeca , CHINEA SANTIAGO, Glay , REYES ACOSTA, Osvaldo , FERNÁNDEZ MASSÓ, Julio, Raúl , GARCÍA DEL BARCO HERRERA, Diana , BERLANGA ACOSTA, Jorge, Amador , MUSACCHIO LASA, Alexis
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公开(公告)号：EP1956031A1
公开(公告)日：2008-08-13
申请号：EP06817994.4
申请日：2006-11-20
发明人： LUGO GONZÁLEZ, Juana, María , ESTRADA GARCÍA, Mario, Pablo , RODRÍGUEZ MALLON, Alina , CARPIO GONZÁLEZ, Yamila , MORALES ROJAS, Antonio , RODRIGO GONZÁLEZ DE SOSA, Osmany , MORALES FERNÁNDEZ, Reynold , HERRERA MIYARES, Fidel, Francisco
IPC分类号： C07K14/575
CPC分类号： A61K38/17 , A01K61/80 , A23K20/147 , A23K50/80 , C07K14/57563 , Y02A40/845
摘要： The present invention is related to the use of variants of the Pituitary Adenylate Cyctase-Activating Polypeptide (PACAP) to stimulate the growth and to improve the immunological system of aquatic organisms. The variants of the peptide were provided by immersion, injection or as a food additive.
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6.发明公开USE OF PACAP FOR TREATING VIRAL INFECTIONS IN AQUATIC ORGANISMS 有权PACAP ZUR BEHANDLUNG VIRALER INFEKTIONEN BEI AQUATISCHEN LEBEWESEN
公开(公告)号：EP2647369A1
公开(公告)日：2013-10-09
申请号：EP11807854.2
申请日：2011-11-30
发明人： ESTRADA GARCÍA, Mario, Pablo , LUGO GONZÁLEZ, Juana, María , CARPIO GONZÁLEZ, Yamila , TAFALLA PIÑEIRO, Carolina
IPC分类号： A61K9/08 , A61K38/22 , A61K31/7056
CPC分类号： A61K38/2278 , A61K9/0019 , A61K9/0056 , A61K9/08 , A61K9/5153 , A61K31/7056 , A61K38/22 , A61K2300/00
摘要： The present invention relates to the use of pituitary adenylate cyclase activating polypeptide (PACAP) in the treatment of viral diseases and infectious diseases caused by viruses in aquatic organisms. PACAP, alone or combined with an antiviral molecule, demonstrated its effectiveness by increasing the survival of fish or crustaceans infected by viruses when it was administered orally, by injection or by immersion baths. Furthermore, it was observed that treated organisms keep or increase its weight as compared to infected and non-treated organisms. PACAP or PACAP-containing combinations decreased the viral load in tissues and organs susceptible to viral infections as it was determined by RT-PCR.
摘要翻译： 本发明涉及垂体腺苷酸环化酶活化多肽（PACAP）用于治疗由水生生物体中的病毒引起的病毒性疾病和感染性疾病的用途。 单独或与抗病毒分子组合的PACAP通过口服，注射或浸浴进行口服，通过增加感染病毒的鱼或甲壳动物的存活来证明其有效性。 此外，观察到与感染和未处理的生物体相比，被处理的生物体保持或增加其重量。 含PACAP或含PACAP的组合降低了病毒感染病毒感染的组织和器官中的病毒载量，如通过RT-PCR测定的。
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7.发明授权
公开(公告)号：EP1956031B1
公开(公告)日：2010-09-15
申请号：EP06817994.4
申请日：2006-11-20
发明人： LUGO GONZÁLEZ, Juana, María , ESTRADA GARCÍA, Mario, Pablo , RODRÍGUEZ MALLON, Alina , CARPIO GONZÁLEZ, Yamila , MORALES ROJAS, Antonio , RODRIGO GONZÁLEZ DE SOSA, Osmany , MORALES FERNÁNDEZ, Reynold , HERRERA MIYARES, Fidel, Francisco
IPC分类号： C07K14/575
CPC分类号： A61K38/17 , A01K61/80 , A23K20/147 , A23K50/80 , C07K14/57563 , Y02A40/845
摘要： The present invention is related to the use of variants of the Pituitary Adenylate Cyctase-Activating Polypeptide (PACAP) to stimulate the growth and to improve the immunological system of aquatic organisms. The variants of the peptide were provided by immersion, injection or as a food additive.
摘要翻译： 本发明涉及使用垂体腺苷酸激活多肽（PACAP）的变体刺激生长并改善水生生物的免疫系统。 通过浸渍，注射或作为食品添加剂提供肽的变体。
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8.发明公开
公开(公告)号：EP2767290A1
公开(公告)日：2014-08-20
申请号：EP12783080.0
申请日：2012-10-01
IPC分类号： A61K38/17 , C07K14/435
CPC分类号： A61K39/39 , A23K20/147 , A61K38/00 , C07K14/461
摘要： The present invention relates to antimicrobial peptides, isolated and purified from extracts of tilapia ( Oreochromis niloticus ) gills. Such peptides may be produced by chemical synthesis or by expression in heterologous systems, such as bacteria and yeasts, by conventional molecular biology techniques. These peptides show antimicrobial activity against various organisms, including Gram positive bacteria, Gram negative bacteria, fungi and viruses. The invention also includes compositions for controlling pathogens comprising these antimicrobial peptides. The use of such peptides in vaccine preparations, as molecular adjuvants, is also part of the invention.
摘要翻译： 本发明涉及从罗非鱼（Oreochromis niloticus）鳃提取物中分离和纯化的抗微生物肽。 这些肽可以通过化学合成或通过常规分子生物学技术在异源系统如细菌和酵母中表达来产生。 这些肽显示出对各种生物体的抗菌活性，包括革兰氏阳性菌，革兰氏阴性菌，真菌和病毒。 本发明还包括用于控制包含这些抗微生物肽的病原体的组合物。 疫苗制剂中作为分子佐剂使用这些肽也是本发明的一部分。
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