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    Indolocarbazole derivatives and their use for the treatment of prostate gland disorders
    8.
    发明公开
    Indolocarbazole derivatives and their use for the treatment of prostate gland disorders 失效
    吲哚并咔唑衍生物及其用于治疗前列腺疾病的用途

    公开(公告)号：EP0839814A3

    公开(公告)日：1998-09-16

    申请号：EP98200023.4

    申请日：1994-05-27

    申请人： CEPHALON, INC. ,  KYOWA HAKKO KOGYO CO., LTD.

    发明人： Dionne, Craig A. ,  Contreras, Patricia C. ,  Murakata, Chikara

    IPC分类号： C07D498/22 ,  C07D487/14 ,  A61K31/55

    CPC分类号： C07D487/14 ,  A61K31/55 ,  C07H19/04

    摘要： The invention relates to novel indolocarbazole derivatives, eg. of formula III
    (wherein:
    R 1 is selected from the group consisting of halogen, CH 2 OCONHR 14 and NHCO 2 R 14 ; R 2 is selected from the group consisting of hydrogen and halogen; X is selected from the group consisting of CO 2 CH 3 , CH 2 OH and CONHR 15 ; R 14 represents lower alkyl; and R 15 is hydrogen, hydroxy substituted lower alkyl, or aryl; with the proviso that when R 1 = halogen and R 2 = hydrogen, X is neither CO 2 CH 3 nor CH 2 OH; and with the proviso that when R 1 = R 2 = halogen, X is not CO 2 CH 3 ; and with the proviso that when R 1 = R 2 = Br, X is not CONHC 6 H 5 ) which are useful in the treatment of pathological conditions of the prostate gland.

    摘要翻译： 本发明涉及新的吲哚并咔唑衍生物， （其中：R 1选自卤素，CH 2 OCONHR 14和NHCO 2 R 14; R 2选自氢和卤素; X选自CO 2 CH 3，CH 2 OH和CONHR 15; R 14表示低级烷基 ;并且R 15是氢，羟基取代的低级烷基或芳基;条件是当R 1 =卤素并且R 2 =氢时，X既不是CO 2 CH 3也不是CH 2 OH;并且条件是当R 1 = R 2 =卤素时，X不是CO 2 CH 3 ;并且条件是当R1 = R2 = Br时，X不是CONHC6H5），其可用于治疗前列腺的病理状况。

    Indolocarbazole derivatives and their use for the treatment of prostate gland disorders
    9.
    发明公开
    Indolocarbazole derivatives and their use for the treatment of prostate gland disorders 失效
    吲哚并衍生物及其在前列腺疾病的治疗

    公开(公告)号：EP0839814A2

    公开(公告)日：1998-05-06

    申请号：EP98200023.4

    申请日：1994-05-27

    申请人： CEPHALON, INC. ,  KYOWA HAKKO KOGYO CO., LTD.

    发明人： Dionne, Craig A. ,  Contreras, Patricia C. ,  Murakata, Chikara

    IPC分类号： C07D498/22 ,  C07D487/14 ,  A61K31/55

    CPC分类号： C07D487/14 ,  A61K31/55 ,  C07H19/04

    摘要： The invention relates to novel indolocarbazole derivatives, eg. of formula III


    (wherein:
    R 1 is selected from the group consisting of halogen, CH 2 OCONHR 14 and NHCO 2 R 14 ;
    R 2 is selected from the group consisting of hydrogen and halogen;
    X is selected from the group consisting of CO 2 CH 3 , CH 2 OH and CONHR 15 ;
    R 14 represents lower alkyl; and
    R 15 is hydrogen, hydroxy substituted lower alkyl, or aryl; with the proviso that when R 1 = halogen and R 2 = hydrogen, X is neither CO 2 CH 3 nor CH 2 OH; and with the proviso that when R 1 = R 2 = halogen, X is not CO 2 CH 3 ; and with the proviso that when R 1 = R 2 = Br, X is not CONHC 6 H 5 )
    which are useful in the treatment of pathological conditions of the prostate gland.

    摘要翻译： 本发明涉及新颖的吲哚咔唑衍生物，例如式III的（worin，R <1>被选自卤素，CH2OCONHR <14>和NHCO 2 <14> - [R <2>中选择从选择的。 选自由氢和卤素; X选自下组：CO 2 CH 3中选择，CH 2 OH和CONHR <15> - [R <14> darstellt低级烷基;且R <15>为氢，羟基substituiertem低级烷基或芳基;与 条件做了当R卤素<1> =和R氢<2> =，X既不是CO2CH3也不CH 2 OH;和前提​​条件做了当R <1> = R <2> =卤素，X不是CO 2 CH 3;以及与所述 当没有条件 - [R <1> = R <2> = Br的，X不是CONHC6H5），它们是在前列腺的病理状况的治疗是有用的。