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公开(公告)号：EP1186655A4
公开(公告)日：2003-04-09
申请号：EP00931647
申请日：2000-06-01
发明人： KITAMURA TOSHIO , MORITA SUMIYO
CPC分类号： C07K14/005 , C12N7/00 , C12N2740/10022 , C12N2740/10051 , C12N2740/10052
摘要： A virus-producing cell sustaining an ability to produce a virus at a high titer is successfully constructed by expressing a virus structural gene under the regulation by EF1α promoter. In this virus-producing cell, the virus structural gene is ligated to a selection marker gene via IRES and domains other than the protein coding domain are eliminated from the DNA encoding the virus structural protein. Thus, reduction of the titer due to the cell passage can be prevented and the appearance of a wild type virus caused by unfavorable recombination of the virus genome can be inhibited.
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公开(公告)号：EP1215284A4
公开(公告)日：2004-05-19
申请号：EP00956961
申请日：2000-09-06
发明人： KITAMURA TOSHIO , MORITA SUMIYO
IPC分类号： A61K38/00 , C07K14/475 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/12 , A01K67/027 , A61K38/18 , A61K48/00 , C07K16/18 , C12N5/10 , C12Q1/68 , G01N33/50
CPC分类号： C07K14/475 , A61K38/00
摘要： A gene encoding a novel protein which is homologous with fruit-fly TSG is isolated from a cDNA library originating in mouse embryo AGM domain by using an originally developed cloning method specific to a gene encoding a membrane secretory protein. This gene is useful in developing drugs which regulate the generation of hematopoietic stem cell, immune/hematopoietic functions, etc.
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