-
1.发明公开NANOPARTICULES DE SILICIUM POREUX FONCTIONNALISEES ET LEURS UTILISATIONS EN THERAPIE PHOTODYNAMIQUE 有权功能化的多孔硅纳米颗粒及其用途在光动力治疗
公开(公告)号：EP2831081A1
公开(公告)日：2015-02-04
申请号：EP13716977.7
申请日：2013-03-26
申请人： Centre National de la Recherche Scientifique (CNRS) , Université Montpellier 2, Sciences et Techniques , The Regents of the University of California , Ecole Nationale Supérieure de Chimie de Montpellier
发明人： CUNIN, Frédérique , DURAND, Jean-Olivier , SAILOR, Michael J. , GARCIA, Marcel , SECRET, Emilie , GARY-BOBO, Magali , MAYNADIER, Marie , MORERE, Alain
IPC分类号： C07D487/22 , A61K31/409 , A61K41/00 , H01L51/00
CPC分类号： A61K41/0071 , A61K31/28 , A61K31/315 , A61K31/409 , A61K41/008 , A61N5/062 , C09B47/00 , Y10T428/2982
摘要： The invention relates to nanovectors of formula (I) that can be used simultaneously for the targeting, imaging and treatment, by means of photodynamic therapy, of cancer cells, and to biodegradable silicon nanoparticles containing a variety of photosensitizing molecules, in particular porphyrins, capable of targeting diseased cells and inducing cell death by means of excitation in the near-infrared region (> 600 nm) in monophotonic and biphotonic modes. According to the invention, in formula (I), (AA) is a porous silicon nanoparticle.
-
2.发明授权NANOPARTICULES DE SILICIUM POREUX FONCTIONNALISEES ET LEURS UTILISATIONS EN THERAPIE PHOTODYNAMIQUE 有权FERKTIONALISIERTEPORÖSESILICIUMNANOPARTIKEL UND VERWENDUNG DAVON IN DER PHOTODYNAMISCHEN THERAPIE
公开(公告)号：EP2831081B1
公开(公告)日：2016-10-19
申请号：EP13716977.7
申请日：2013-03-26
申请人： Centre National de la Recherche Scientifique (CNRS) , Université Montpellier 2, Sciences et Techniques , The Regents of the University of California , Ecole Nationale Supérieure de Chimie de Montpellier
发明人： CUNIN, Frédérique , DURAND, Jean-Olivier , SAILOR, Michael J. , GARCIA, Marcel , SECRET, Emilie , GARY-BOBO, Magali , MAYNADIER, Marie , MORERE, Alain
IPC分类号： C07D487/22 , C09K11/59 , A61K41/00 , A61K31/409 , B82Y5/00 , A61P35/00
CPC分类号： A61K41/0071 , A61K31/28 , A61K31/315 , A61K31/409 , A61K41/008 , A61N5/062 , C09B47/00 , Y10T428/2982
-
3.发明公开
公开(公告)号：EP2448600A1
公开(公告)日：2012-05-09
申请号：EP10727003.5
申请日：2010-07-02
申请人： INSERM - Institut National de la Santé et de la Recherche Médicale , Centre National de la Recherche Scientifique CNRS , Universite De Montpellier 1 , Université Montpellier 2 Sciences et Techniques
发明人： GARCIA, Marcel , MORERE, Alain , GARY-BOBO, Magali , CERUTTI, Martine , EL CHEIKH, Khaled , BASILE, Ilaria , NIRDE, Philippe
CPC分类号： A61K47/48092 , A61K47/549
摘要： The invention relates to conjugates of products of interest and of compounds targeting the cation-independent mannose 6-phosphate receptor with a high affinity. The invention also relates to their applications, for instance in enzyme replacement therapies.
-
4.发明公开METHODE DE SYNTHESE DE LA 2 -ACETYL-1-PYRROLINE ET DE SON PRECURSEUR STABLE, MARQUE ISOTOPIQUEMENT OU NON 有权PROCESS FOR 2-乙酰-1-吡咯啉WITH任选的预同位素标记合成与HIS STABLE
公开(公告)号：EP2445874A1
公开(公告)日：2012-05-02
申请号：EP10726102.6
申请日：2010-06-24
申请人： Centre National de la Recherche Scientifique CNRS , Université Montpellier 2 Sciences et Techniques
IPC分类号： C07D207/20 , C07D211/70
CPC分类号： C07D211/70 , C07D207/20
摘要： The present invention relates to a method for synthesising a compound of the following formula (I), where R is a methyl or ethyl group, n is 1 or 2, and X is a CH
2 or CD
2 group, from a compound of the following formula (II), where R and n are as defined above. The invention also relates to a method for assaying the compounds of formula (I) using a corresponding deuterated derivative as an internal reference, as well as to the use of ketal derivatives of compounds of formula (I) as a stable precursor, in particular in a flavouring composition.摘要翻译： 本发明涉及一种用于synthetizing下述式（I）的化合物：worin R是甲基或乙基，n是1或2，并且X是CH 2或CD2组，由下式的化合物 （II）：worin R和n如上所定义，并且因此涉及一种用于使用相应的氘化衍生物的式（I）化合物测定作为内部参考，以及所述化合物的用途，缩酮衍生物的 在调味组合物中的式（I），其为稳定的前体，在particulare。
-
5.发明授权BIPHOTONIC PHOTOSENSITIZERS, NANOPARTICLES CONTAINING THE SAME AND THEIR USE AS DRUGS 有权生物光子光敏剂纳米粒子与它和它们作为药物的用途
公开(公告)号：EP2513083B1
公开(公告)日：2016-04-06
申请号：EP10790539.0
申请日：2010-12-07
申请人： Centre National de la Recherche Scientifique (CNRS) , Universite Rennes 1 , INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Montpellier 2 Sciences et Techniques
发明人： BREVET, David , RAEHM, Laurence , BLANCHARD-DESCE, Mireille , MONGIN, Olivier , GARY-BOBO-SABLE-TEYCHENE, Magali , GARCIA, Marcel , MORERE, Alain , DURAND, Jean-Olivier
IPC分类号： C07D333/16 , C07D333/20 , C07D495/04 , A61K41/00 , A61K47/48 , A61P35/00
CPC分类号： C07F7/1836 , B82Y30/00 , C07D333/16 , C07D333/20 , C07D409/10 , C07D495/04 , C07F7/0801 , C07F7/10 , C07H23/00
-
6.发明公开BIPHOTONIC PHOTOSENSITIZERS, NANOPARTICLES CONTAINING THE SAME AND THEIR USE AS DRUGS 有权生物光子光敏剂纳米粒子与它和它们作为药物的用途
公开(公告)号：EP2513083A1
公开(公告)日：2012-10-24
申请号：EP10790539.0
申请日：2010-12-07
申请人： CNRS Centre National de la Recherche Scientifique , Universite Rennes 1 , INSERM (Institut National de la Santé et de la Recherche Médicale) , Université Montpellier 2 Sciences et Techniques
发明人： BREVET, David , RAEHM, Laurence , BLANCHARD-DESCE, Mireille , MONGIN, Olivier , GARY-BOBO-SABLE-TEYCHENE, Magali , GARCIA, Marcel , MORERE, Alain , DURAND, Jean-Olivier
IPC分类号： C07D333/16 , C07D333/20 , C07D495/04 , A61K41/00 , A61K47/48 , A61P35/00
CPC分类号： C07F7/1836 , B82Y30/00 , C07D333/16 , C07D333/20 , C07D409/10 , C07D495/04 , C07F7/0801 , C07F7/10 , C07H23/00
摘要： The invention relates to compounds of formula (I) : the groups A and B represent independently from each other -CH=CH-, or -C≡C-, the terms t, u, v, w represent, independently from each other, values ranging from 0 to 9, the groups Y
1 and Y
2 can represent independently from each other an alkyl group (linear, branched or substituted) carrying from 1 to 9 carbon atoms, the groups Z
1 , Z
2 , Z
3 , and Z
4 can represent independently from each other a chemically reactive group W, such as OH, NH
2 , SH, the groups Z
5 and Z
6 represent independently from each other a hydrogen atom, silica nanoparticles functionalized by these compounds, and their use as drugs.-
7.发明授权METHODE DE SYNTHESE DE LA 2-ACETYL-1-PYRROLINE ET DE SON PRECURSEUR STABLE, MARQUE ISOTOPIQUEMENT OU NON 有权合成2-乙酰基-1-吡咯啉及其稳定的前体的方法同位素或非
公开(公告)号：EP2445874B1
公开(公告)日：2017-11-29
申请号：EP10726102.6
申请日：2010-06-24
申请人： Centre National de la Recherche Scientifique (C.N.R.S.) , Université Montpellier 2 Sciences et Techniques
IPC分类号： C07D207/20 , C07D211/70
CPC分类号： C07D211/70 , C07D207/20
-
8.发明授权
公开(公告)号：EP2448600B1
公开(公告)日：2016-03-30
申请号：EP10727003.5
申请日：2010-07-02
申请人： INSERM - Institut National de la Santé et de la Recherche Médicale , Centre National de la Recherche Scientifique (CNRS) , UNIVERSITE DE MONTPELLIER
发明人： GARCIA, Marcel , MORERE, Alain , GARY-BOBO, Magali , CERUTTI, Martine , EL CHEIKH, Khaled , BASILE, Ilaria , NIRDE, Philippe
CPC分类号： A61K47/48092 , A61K47/549
-
-
-
-
-
-
-
搜索结果
8 条记录 (耗时 0.028 秒)
