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1.发明授权PROTHESES BIOACTIVES EN MATERIAU CONDUCTEUR REVETU D'UN POLYMERE ET D'UNE SUBSTANCE A PROPRIETES IMMUNOSUPPRESSIVES, ANTISTENOSE ET ANTITHROMBOSE 有权生物活性移植材料由导电用聚合物，有免疫抑制，ANTISTENOSEN及抗血栓性的物质COATED
公开(公告)号：EP1131113B1
公开(公告)日：2005-07-20
申请号：EP99972115.2
申请日：1999-11-15
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE , INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) , Kerckhoff-Klinik GmbH
发明人： LE MOEL, Alain , BETZ, Natacha , BUREAU, Christophe , DENIAU, Guy , BAQUEY, Charles , DELERIS, Gérard , HABERBOSCH, Werner
CPC分类号： A61L33/0029 , A61F2/06 , A61F2/82 , A61L27/28 , A61L27/34 , A61L27/54 , A61L2300/258 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2400/18
摘要： The invention concerns a bioactive prosthesis comprising a support coated with a polymer layer with reactive functions, and a bioactive substance fixed on the prosthesis via said reactive functions so as to be gradually released on a site for implanting the prosthesis. Such prostheses are useful in the field of cardiology to avoid for example restenosis resulting from implantation of stents in coronary arteries.
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2.发明授权CYCLOPEPTIDES, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION COMME INHIBITEUR OU ACTIVATEUR DE L'ANGIOGENESE 有权CYCLO肽，其制造方法相同，它们用于抑制或细胞刺激血管生成
公开(公告)号：EP1328546B1
公开(公告)日：2007-02-21
申请号：EP01974427.5
申请日：2001-10-02
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE , Université Victor Segalen Bordeaux 2 , Université Bordeaux 1
摘要： The invention concerns cyclic peptides, the method for preparing them and their use as angiogenesis inhibitor or activator. Said cyclic peptides comprise the following peptide sequence: -Arg-Ile-Lys-Pro-Gln-Gly-. They can also be used in angiogenesis inhibiting systems comprising a support (1) whereon the cyclic peptide is fixed by an organic spacer arm (3), optionally provided with a motif (4) capable of being cleaved by an enzymatic system.
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3.发明公开CYCLOPEPTIDES, LEUR PROCEDE DE PREPARATION ET LEUR UTILISATION COMME INHIBITEUR OU ACTIVATEUR DE L'ANGIOGENESE 有权CYCLO肽，其制造方法相同，它们用于抑制或细胞刺激血管生成
公开(公告)号：EP1328546A2
公开(公告)日：2003-07-23
申请号：EP01974427.5
申请日：2001-10-02
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE , Université Victor Segalen Bordeaux 2 , Université Bordeaux 1
摘要： The invention concerns cyclic peptides, the method for preparing them and their use as angiogenesis inhibitor or activator. Said cyclic peptides comprise the following peptide sequence: -Arg-Ile-Lys-Pro-Gln-Gly-. They can also be used in angiogenesis inhibiting systems comprising a support (1) whereon the cyclic peptide is fixed by an organic spacer arm (3), optionally provided with a motif (4) capable of being cleaved by an enzymatic system.
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4.发明公开PROTHESES BIOACTIVES A PROPRIETES IMMUNOSUPPRESSIVES, ANTISTENOSE ET ANTITHROMBOSE 有权生物活性移植材料由导电用聚合物，有免疫抑制，ANTISTENOSEN及抗血栓性的物质COATED
公开(公告)号：EP1131113A1
公开(公告)日：2001-09-12
申请号：EP99972115.2
申请日：1999-11-15
申请人： COMMISSARIAT A L'ENERGIE ATOMIQUE , INSTITUT NATIONAL DE LA SANTE ET DE LARECHERCHE MEDICALE (INSERM) , Justus-Liebig- Universitat Giessen
发明人： LE MOEL, Alain , BETZ, Natacha , BUREAU, Christophe , DENIAU, Guy , BAQUEY, Charles , DELERIS, Gérard , HABERBOSCH, Werner
CPC分类号： A61L33/0029 , A61F2/06 , A61F2/82 , A61L27/28 , A61L27/34 , A61L27/54 , A61L2300/258 , A61L2300/406 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2400/18
摘要： The invention concerns a bioactive prosthesis comprising a support coated with a polymer layer with reactive functions, and a bioactive substance fixed on the prosthesis via said reactive functions so as to be gradually released on a site for implanting the prosthesis. Such prostheses are useful in the field of cardiology to avoid for example restenosis resulting from implantation of stents in coronary arteries.
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