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8 条记录 (耗时 0.01 秒)

    PHARMACEUTICAL COMPOSITION INCLUDING 5-{4-(AMINOSULFONYL)PHENYL}-2,2-DIMETHYL-4-(3-FLUOROPHENYL)-3(2H)-FURANONE AND CAPSULE FORMULATION INCLUDING THE PHARMACEUTICAL COMPOSITION
    2.
    发明公开
    PHARMACEUTICAL COMPOSITION INCLUDING 5-{4-(AMINOSULFONYL)PHENYL}-2,2-DIMETHYL-4-(3-FLUOROPHENYL)-3(2H)-FURANONE AND CAPSULE FORMULATION INCLUDING THE PHARMACEUTICAL COMPOSITION 审中-公开
    （4-氟苯基）-2,2-二甲基-4-（3-氟苯基）-3（2H） - 呋喃酮

    公开(公告)号：EP3099294A4

    公开(公告)日：2017-09-06

    申请号：EP15742755

    申请日：2015-01-29

    申请人： CRYSTALGENOMICS INC

    发明人： KIM BYUNG-HA ,  AHN SIK IL ,  PARK JAE-YEON ,  KIM TAE RYONG ,  CHO JOONG MYUNG ,  RO SEONGGU

    IPC分类号： A61K9/48 ,  A61K31/34

    CPC分类号： A61K31/34 ,  A61K9/485 ,  A61K9/4858 ,  A61K9/4866 ,  A61K31/397 ,  A61K31/42

    摘要： The present invention relates to a pharmaceutical composition including (i) the compound of Formula 1 described in the specification or a pharmaceutically acceptable salt thereof, (ii) a pharmaceutically acceptable diluent, and (iii) a pharmaceutically acceptable lubricant. The compound of Formula 1 or pharmaceutically acceptable salt thereof has a 50% volume particle diameter (d(0.5)) of 3 μm to 9 μm. The pharmaceutical composition of the present invention has the advantages of good stability, high dissolution rate, improved content uniformity, and excellent pharmacokinetic properties. Due to these advantages, the pharmaceutical composition of the present invention is effective in treating inflammation or pain.

    摘要翻译： 本发明涉及药物组合物，其包含（i）说明书中描述的式1的化合物或其药学上可接受的盐，（ii）药学上可接受的稀释剂，和（iii）药学上可接受的润滑剂。 式1的化合物或其药学上可接受的盐具有3μm至9μm的50％体积粒径（d（0.5））。 本发明的药物组合物具有稳定性好，溶出速率快，含量均匀性好，药代动力学性能好等优点。 由于这些优点，本发明的药物组合物在治疗炎症或疼痛方面是有效的。