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    A GINSENG PREPARATION USING VINEGAR AND PROCESS FOR THEREOF
    6.
    发明公开
    A GINSENG PREPARATION USING VINEGAR AND PROCESS FOR THEREOF 审中-公开
    人参制剂用醋及其制造方法

    公开(公告)号：EP1660107A4

    公开(公告)日：2008-06-04

    申请号：EP03818123

    申请日：2003-08-18

    申请人： YUYU INC

    发明人： KO SUNG KWON

    IPC分类号： A61K31/704 ,  A61K36/00 ,  A61K36/258

    CPC分类号： A61K36/258

    摘要： The present invention relates to a ginseng preparation using vinegar and a process for preparing the same, more particularly to a ginseng preparation comprising high concentrations of ginsenosides (Rg3, Rg5, and Rh1), which are generated by heat and exist only small amounts in red ginseng comprising various organic acids of vinegar, including citric acid, which is prepared by adding vinegar of pH 2 to 4 to ginseng, heat-extracting the same for 0.5 to 24 hours, and a method for preparing the ginseng preparation.

    FURANCARBONYLGUANIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM
    7.
    发明公开
    FURANCARBONYLGUANIDINE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM 审中-公开
    呋喃甲硼烷基胍衍生物，它们的制备和含有它们的药物组合物

    公开(公告)号：EP1697335A1

    公开(公告)日：2006-09-06

    申请号：EP04808564.1

    申请日：2004-12-24

    申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  Yuyu Inc.

    发明人： YI, Kyu Yang ,  LEE, Sun Kyung ,  KIM, Nak Jeong ,  SUH, Jee Hee ,  HWANG, Soon Hee ,  LEE, Byung Ho ,  SEO, Ho Won ,  HWANG, Sun Kyung ,  YOO, Sung Eun ,  LEE, Kyung Hee

    IPC分类号： C07D307/68

    CPC分类号： C07D307/68

    摘要： The present invention relates to furancarbonylguanidine derivatives, a preparation method thereof and a pharmaceutical composition comprising the same. Furancarbonylguanidine derivatives of the present invention inhibit NHE-1 (sodium-hydrogen exchanger isoform 1), which helps recovery of heart function damaged from ischemia/ reperfusion and decreases myocardial infarction rate, indicating that they have protective effect on myocardial cells. Thus, furancarbonylguanidine derivatives of the present invention can be ef­fectively used for the prevention and the treatment of ischemic heart diseases such as myocardial infarction, arrhythmia, angina pectoris, etc, and also a promising candidate for a heart protecting agent applied to reperfusion therapy including thrombolytics or cardiac surgery including coronary artery bypass graft, percutaneous transluminal coronary angioplasty, etc.

    摘要翻译： 本发明涉及呋喃羰基胍衍生物，其制备方法和包含其的药物组合物。 本发明的呋喃羰基胍衍生物抑制NHE-1（钠 - 氢交换体亚型1），其有助于恢复由缺血/再灌注损伤的心脏功能并降低心肌梗塞率，表明它们对心肌细胞具有保护作用。 因此，本发明的呋喃羰基胍衍生物可以有效地用于心肌梗塞，心律失常，心绞痛等缺血性心脏病的预防和治疗，也是用于包括溶栓剂在内的再灌注治疗中的心脏保护剂的有希望的候选者 或心脏手术包括冠状动脉旁路移植术，经皮腔内冠状动脉血管成形术等。

    BENZOTHIOPHEN-2-CARBONYLGUANIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
    9.
    发明授权
    BENZOTHIOPHEN-2-CARBONYLGUANIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 有权
    苯并噻吩-2- CARBONYLGUANIDINDERIVATE，生产，药品成分包含此

    公开(公告)号：EP1831192B1

    公开(公告)日：2011-08-24

    申请号：EP05822428.8

    申请日：2005-12-27

    申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  Yuyu Inc.

    发明人： YI, Kyu Yang ,  LEE, SunKyung ,  SUH, Jee Hee ,  KIM, Nak Jeong ,  LEE, Hyunsuk ,  LEE, Byung-Ho ,  YOO, Sung-eun ,  LEE, Kyung-Hee, 204-1005 Pureunmaeul Byucksan Apt. ,  LEE, Yong Oh

    IPC分类号： C07D333/70

    CPC分类号： C07D333/70

    摘要： The present invention is related to benzothiophen-2-carbonylguanidine derivatives, a preparation method thereof, and pharmaceutical compositions containing the same. The derivatives have potent inhibitory effect on the sodium/hydrogen exchanger NHE-I, improve the functional recovery of ischemia/reperfusion-induced heart injury in isolated ischemic heart models, and significantly reduce the myocardiac infarct size in in vivo ischemic animal models, thereby showing excellent cardioprotective effects. Also, the derivatives are protective of both neuronal cells and the brain as proven by their protective effects on neuronal cells from necrosis and apoptosis and by their ability to significantly reduce cerebral infarct sizes in in vivo ischemic brain models. The derivatives can be effectively used for the prevention and treatment of ischemic heart diseases such as myocardiac infarction, arrhythmia, angina pectoris and the like, and cerebrovascular diseases such as cerebral stroke and be used as cardioprotective agents to the patients undergoing reperfusion therapy including chemicals such as thrombolytic agents, or surgery such as coronary artery bypass and percutaneous transluminal coronary angioplasty.

    BENZOTHIOPHEN-2-CARBONYLGUANIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME
    10.
    发明公开
    BENZOTHIOPHEN-2-CARBONYLGUANIDINE DERIVATIVES, PREPARATION THEREOF, AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 有权
    苯并噻吩-2- CARBONYLGUANIDINDERIVATE，生产，药品成分包含此

    公开(公告)号：EP1831192A1

    公开(公告)日：2007-09-12

    申请号：EP05822428.8

    申请日：2005-12-27

    申请人： KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY ,  Yuyu Inc.

    发明人： YI, Kyu Yang ,  LEE, SunKyung ,  SUH, Jee Hee ,  KIM, Nak Jeong ,  LEE, Hyunsuk ,  LEE, Byung-Ho ,  YOO, Sung-eun ,  LEE, Kyung-Hee, 204-1005 Pureunmaeul Byucksan Apt. ,  LEE, Yong Oh

    IPC分类号： C07D333/70

    CPC分类号： C07D333/70

    摘要： The present invention is related to benzothiophen-2-carbonylguanidine derivatives, a preparation method thereof, and pharmaceutical compositions containing the same. The derivatives have potent inhibitory effect on the sodium/hydrogen exchanger NHE-I, improve the functional recovery of ischemia/reperfusion-induced heart injury in isolated ischemic heart models, and significantly reduce the myocardiac infarct size in in vivo ischemic animal models, thereby showing excellent cardioprotective effects. Also, the derivatives are protective of both neuronal cells and the brain as proven by their protective effects on neuronal cells from necrosis and apoptosis and by their ability to significantly reduce cerebral infarct sizes in in vivo ischemic brain models. The derivatives can be effectively used for the prevention and treatment of ischemic heart diseases such as myocardiac infarction, arrhythmia, angina pectoris and the like, and cerebrovascular diseases such as cerebral stroke and be used as cardioprotective agents to the patients undergoing reperfusion therapy including chemicals such as thrombolytic agents, or surgery such as coronary artery bypass and percutaneous transluminal coronary angioplasty.