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1.发明公开CAPSULES CONTAINING AQUEOUS FILL COMPOSITIONS STABILIZED WITH DERIVATIZED CYCLODEXTRIN 审中-公开与含水胶囊填充物组合物，具有衍生化环糊精稳定化
公开(公告)号：EP1545477A4
公开(公告)日：2006-11-22
申请号：EP03759605
申请日：2003-09-12
申请人： CYDEX INC
IPC分类号： A61K9/48 , A61K9/52 , A61K31/724
CPC分类号： A61K31/724 , A61K9/4866 , A61K9/4891
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2.发明公开INHALANT FORMULATION CONTAINING SULFOALKYL ETHER CYCLODEXTRIN AND CORTICOSTEROID 有权磺烷基醚环糊精和含皮质类固醇INHALATIONSSTOFFORMULIERUNG
公开(公告)号：EP1732512A4
公开(公告)日：2008-07-23
申请号：EP05704917
申请日：2004-12-31
申请人： CYDEX INC
IPC分类号： A61K9/08 , A61K9/00 , A61K9/12 , A61K9/14 , A61K31/16 , A61K31/57 , A61K31/715 , A61K47/40 , A61K47/48 , C08B37/16
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/08 , A61K31/137 , A61K31/167 , A61K31/46 , A61K31/56 , A61K31/573 , A61K31/58 , A61K47/40 , A61K47/6951 , B82Y5/00 , A61K31/16 , A61K2300/00 , A61K31/57 , A61K31/715
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公开(公告)号：EP1485110A4
公开(公告)日：2007-08-29
申请号：EP03723771
申请日：2003-03-19
申请人： CYDEX INC
IPC分类号： A61K9/00 , A61K31/05 , A61K31/724 , A61K47/32 , A61K47/34 , A61K47/40 , A61K47/46 , A61K47/48
CPC分类号： B82Y5/00 , A61K9/0019 , A61K31/05 , A61K31/724 , A61K47/40 , A61K47/6951 , A61K2300/00
摘要： An injectable formulation of a sedative hypnotic drug, such as the anesthetic drug propofol, that is pharmaceutically stable and demonstrates a reduced incidence of pain upon injection. The formulation of the present invention employs a sulfoalkyl ether cyclodextrin solubilizing and complexing excipient, such as CAPTISOL(R) cyclodextrin (sulfobutyl ether beta-cyclodextrin) to form a true aqueous solution and not a suspension. This formulation minimizes the allergic response and microbial contamination issues typically associated with propofol parenteral formulations. The present formulation may also reduce pain on injection as compared to the known emulsion type propofol formulations. The liquid formulation can be sterile filtered unlike emulsion-type formulations of sedative hypnotics. The liquid formulation can be lyophilized or otherwise dried to yield a solid formulation.
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4.发明公开INHALENT FORMULATION CONTAINING SULFOALKYL ETHER GAMMA-CYCLODEXTRYN AND CORTICOSTEROID 审中-公开吸入制剂磺烷基醚 - γ-环糊精和皮质类固醇
公开(公告)号：EP1729724A4
公开(公告)日：2008-07-23
申请号：EP05704920
申请日：2004-12-31
申请人： CYDEX INC
IPC分类号： A61K9/08 , A61K9/00 , A61K9/12 , A61K9/14 , A61K31/16 , A61K31/57 , A61K31/715 , A61K47/40 , A61K47/48 , C08B37/16
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/08 , A61K31/137 , A61K31/167 , A61K31/46 , A61K31/56 , A61K31/573 , A61K31/58 , A61K47/40 , A61K47/6951 , B82Y5/00 , A61K31/16 , A61K2300/00 , A61K31/57 , A61K31/715
摘要： An inhalable formulation containing SEA-Ϝ-CD and corticosteroid is provided. The formulation is adapted for administration to a subject by nebulization with any known nebulizer. The formulation can be included in a kit. The formulation is administered as an aqueous solution, however, it can be stored as a dry powder, ready-to-use solution, or concentrated composition. The formulation is employed in an improved nebulization system for administering corticosteroid by inhalation. SAE-Ϝ-CD present in the formulation significantly enhances the chemical stability of budesonide. A method of administering the formulation by inhalation is provided. The formulation can also be administered by conventional nasal delivery apparatus. The formulation can include one or more additional therapeutic agents for use in combination with the corticosteroid. SAE-Ϝ-CD is especially useful for solubilizing esterified corticosteroids.
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5.发明公开INHALANT FORMULATION CONTAINING SULFOALKYLETHER CYCLODEXTRIN AND CORTICOSTEROID PREPARED FROM A UNIT DOSE SUSPENSION 审中-公开吸入剂和配方磺烷基醚环糊精的皮质类固醇实现了从单个悬架
公开(公告)号：EP1718276A4
公开(公告)日：2008-07-23
申请号：EP05704919
申请日：2005-01-03
申请人： CYDEX INC
IPC分类号： A61K9/08 , A61K9/00 , A61K9/12 , A61K9/14 , A61K31/16 , A61K31/57 , A61K31/715 , A61K47/40 , A61K47/48 , C08B37/16
CPC分类号： A61K9/0078 , A61K9/0075 , A61K9/08 , A61K31/137 , A61K31/167 , A61K31/46 , A61K31/56 , A61K31/573 , A61K31/58 , A61K47/40 , A61K47/6951 , B82Y5/00 , A61K31/16 , A61K2300/00 , A61K31/57 , A61K31/715
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