公开(公告)号：EP0869814A1

公开(公告)日：1998-10-14

申请号：EP96943170.0

申请日：1996-12-20

申请人： PASTEUR MERIEUX SERUMS ET VACCINS

发明人： FANGET, Bernard ,  FRANCON, Alain

IPC分类号： A61K31 ,  A61K39 ,  A61K47 ,  A61P31

CPC分类号： A61K39/285 ,  A61K9/0019 ,  A61K39/0015 ,  A61K39/12 ,  A61K39/165 ,  A61K39/20 ,  A61K47/183 ,  A61K47/26 ,  A61K2039/5254 ,  A61K2039/70 ,  C12N2710/16734 ,  C12N2710/16751 ,  C12N2760/18434 ,  C12N2760/18451 ,  C12N2760/18734 ,  C12N2760/18751 ,  C12N2770/36234 ,  C12N2770/36251

摘要： Stabilisers for live vaccines and attenuated mono- or multivalent live vaccines, stabilised vaccines containing such stabilisers, and methods for preparing such vaccines, are disclosed. Said stabilisers for vaccines containing one or more attenuated live viruses include one or more components selected from each of the following groups: amino acids, disaccharides, polyalcohols and buffer solutions, with the proviso that one component selected from the disaccharide group is saccharose.

公开(公告)号：EP0869814B1

公开(公告)日：2005-07-20

申请号：EP96943170.9

申请日：1996-12-20

申请人： Sanofi Pasteur

发明人： FANGET, Bernard ,  FRANCON, Alain

IPC分类号： A61K39/12 ,  A61K47/00

CPC分类号： A61K39/285 ,  A61K9/0019 ,  A61K39/0015 ,  A61K39/12 ,  A61K39/165 ,  A61K39/20 ,  A61K47/183 ,  A61K47/26 ,  A61K2039/5254 ,  A61K2039/70 ,  C12N2710/16734 ,  C12N2710/16751 ,  C12N2760/18434 ,  C12N2760/18451 ,  C12N2760/18734 ,  C12N2760/18751 ,  C12N2770/36234 ,  C12N2770/36251

摘要： Stabilisers for live vaccines and attenuated mono- or multivalent live vaccines, stabilised vaccines containing such stabilisers, and methods for preparing such vaccines, are disclosed. Said stabilisers for vaccines containing one or more attenuated live viruses include one or more components selected from each of the following groups: amino acids, disaccharides, polyalcohols and buffer solutions, with the proviso that one component selected from the disaccharide group is saccharose.

公开(公告)号：EP1218499A2

公开(公告)日：2002-07-03

申请号：EP00952452.1

申请日：2000-08-02

申请人： Wyeth

发明人： CLARKE, David, K. ,  JOHNSON, Erik, J. ,  SIDHU, Mohinderjit, S. ,  UDEM, Stephen, A.

IPC分类号： C12N15/09 ,  C12N7/04 ,  A61K39/165 ,  C07K14/12 ,  C12N15/86 ,  C12N5/10

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K39/12 ,  A61K39/165 ,  A61K2039/5254 ,  A61K2039/70 ,  C12N7/00 ,  C12N15/86 ,  C12N2760/18722 ,  C12N2760/18734 ,  C12N2760/18743 ,  C12N2760/18751 ,  C12N2760/18761 ,  C12N2840/20 ,  C12N2840/203

摘要： This invention relates to a method for recombinantly producing, via rescue of mumps virus, a nonsegmented, negative-sense, single-stranded RNA virus, and immunogenic compositions formed therefrom. Additional embodiments relate to methods of producing the mumps virus as an attenuated and/or infectious virus. The recombinant viruses are prepared from cDNA clones, and, accordingly, viruses having defined changes, including nucleotide/polynucleotide deletions, insertions, substitutions and re-arrangements, in the place of the genome are obtained.

公开(公告)号：EP3274447A1

公开(公告)日：2018-01-31

申请号：EP16721253.9

申请日：2016-03-28

申请人： Cadila Healthcare Limited

发明人： GLUECK, Reinhard ,  GIANNINO, Viviana ,  GUPTA, Gaurav

IPC分类号： C12N7/00

CPC分类号： C12N7/00 ,  C12N7/04 ,  C12N2760/18721 ,  C12N2760/18734 ,  C12N2760/18751 ,  C12N2760/18761

摘要： The present invention provides a novel vaccine against mumps composed of highly immunogenic rMuVJL2 (recombinant mumps virus Jeryl Lynn2 based). Further, method to develop said immunogenic composition is described in the present invention. The vaccine according to the present invention is safe, cost effective, highly efficacious and stable and consistent in terms of productivity.

公开(公告)号：EP0790836A4

公开(公告)日：2003-05-28

申请号：EP95941434

申请日：1995-11-30

申请人： DYNCORP ,  NAT INST HEALTH

发明人： CHANOCK ROBERT M ,  PURCELL ROBERT H ,  KAPIKIAN ALBERT Z ,  POTASH LOUIS

IPC分类号： C12N5/00 ,  A61K39/12 ,  A61K39/125 ,  A61K39/13 ,  A61K39/15 ,  A61K39/29 ,  A61P31/12 ,  C12N7/00 ,  C12N7/04 ,  A61K39/145 ,  C12N5/06 ,  C12N7/02

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/5254 ,  C12N2720/12334 ,  C12N2720/12351 ,  C12N2740/10051 ,  C12N2740/14051 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16234 ,  C12N2760/16251 ,  C12N2760/18534 ,  C12N2760/18551 ,  C12N2760/18634 ,  C12N2760/18651 ,  C12N2760/18734 ,  C12N2760/18751 ,  C12N2770/12034 ,  C12N2770/12051 ,  C12N2770/32334 ,  C12N2770/32351 ,  C12N2770/32434 ,  C12N2770/32451 ,  C12N2770/32634 ,  C12N2770/32651

摘要： A novel African Green Monkey Kidney (AGMK) cell line is taught as well as a method for the preparation thereof. The cell line which is free of viable adventitious microbial agents is useful as a substrate for viruses and for the preparation of viral vaccines.

公开(公告)号：EP0790836A1

公开(公告)日：1997-08-27

申请号：EP95941434.0

申请日：1995-11-30

申请人： DYNCORP ,  NATIONAL INSTITUTES OF HEALTH

发明人： CHANOCK, Robert M. ,  PURCELL, Robert H. ,  KAPIKIAN, Albert Z. ,  POTASH, Louis

IPC分类号： C12N5 ,  A61K39 ,  A61P31 ,  C12N7

CPC分类号： C12N7/00 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/5254 ,  C12N2720/12334 ,  C12N2720/12351 ,  C12N2740/10051 ,  C12N2740/14051 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16234 ,  C12N2760/16251 ,  C12N2760/18534 ,  C12N2760/18551 ,  C12N2760/18634 ,  C12N2760/18651 ,  C12N2760/18734 ,  C12N2760/18751 ,  C12N2770/12034 ,  C12N2770/12051 ,  C12N2770/32334 ,  C12N2770/32351 ,  C12N2770/32434 ,  C12N2770/32451 ,  C12N2770/32634 ,  C12N2770/32651 ,  Y02A50/466

摘要： A novel African Green Monkey Kidney (AGMK) cell line is taught as well as a method for the preparation thereof. The cell line which is free of viable adventitious microbial agents is useful as a substrate for viruses and for the preparation of viral vaccines.

公开(公告)号：EP0230265A3

公开(公告)日：1988-12-14

申请号：EP87100420

申请日：1987-01-14

申请人： BEHRINGWERKE AKTIENGESELLSCHAFT

发明人： BERNHARDT, DIETER, DR.

IPC分类号： A61K39/12 ,  A61K47/26 ,  A61K47/42 ,  A61K47/00

CPC分类号： A61K47/42 ,  A61K39/12 ,  A61K47/26 ,  C12N2710/16634 ,  C12N2760/18434 ,  C12N2760/18451 ,  C12N2760/18534 ,  C12N2760/18634 ,  C12N2760/18734 ,  C12N2760/18751 ,  C12N2770/24051 ,  C12N2770/24334 ,  C12N2770/36234 ,  C12N2770/36251

摘要： Es wird ein Verfahren zur Stabilisierung von Virus-Anti genen beschrieben, wobei die Virussuspension mit einer abgebauten und vernetzten Gelatine, einem Disaccharid und einem Pepton versetzt und gegebenenfalls zur Trockene gebracht wird. Auf diese Weise hergestellte Zubereitungen können in einer Vaccine oder einem Diagnostikum verwendet werden.

公开(公告)号：EP0230265A2

公开(公告)日：1987-07-29

申请号：EP87100420.6

申请日：1987-01-14

申请人： BEHRINGWERKE Aktiengesellschaft

发明人： Bernhardt, Dieter, Dr.

IPC分类号： A61K39/12 ,  A61K47/00

CPC分类号： A61K47/42 ,  A61K39/12 ,  A61K47/26 ,  C12N2710/16634 ,  C12N2760/18434 ,  C12N2760/18451 ,  C12N2760/18534 ,  C12N2760/18634 ,  C12N2760/18734 ,  C12N2760/18751 ,  C12N2770/24051 ,  C12N2770/24334 ,  C12N2770/36234 ,  C12N2770/36251

摘要： Es wird ein Verfahren zur Stabilisierung von Virus-Anti­genen beschrieben, wobei die Virussuspension mit einer abgebauten und vernetzten Gelatine, einem Disaccharid und einem Pepton versetzt und gegebenenfalls zur Trockene gebracht wird. Auf diese Weise hergestellte Zubereitungen können in einer Vaccine oder einem Diagnostikum verwendet werden.

摘要翻译： 病毒抗原通过将病毒悬浮液与降解和交联的明胶，二糖和蛋白胨混合，并在适当情况下干燥来稳定。 以这种方式生产的制剂可用于疫苗或诊断辅助剂。