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公开(公告)号：EP2424606B1
公开(公告)日：2015-01-07
申请号：EP10719593.5
申请日：2010-04-29
CPC分类号： A61M25/007 , A61B2017/00247 , A61B2018/00392 , A61M5/158 , A61M25/0084 , A61M2005/1581 , A61M2025/009
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公开(公告)号：EP2432482A1
公开(公告)日：2012-03-28
申请号：EP10723556.6
申请日：2010-05-20
IPC分类号： A61K35/34
CPC分类号： A61K35/34
摘要： The present invention is related to a pharmaceutical composition comprising cells committed to the generation of heart tissue and at least one pharmaceutically acceptable excipient produced according to internationally recognized standards for pharmaceutical product manufacture, a process for the manufacture of such a pharmaceutical composition and a kit for the administration of said pharmaceutical composition which comprises a container containing said pharmaceutical composition.
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公开(公告)号：EP3524980A1
公开(公告)日：2019-08-14
申请号：EP18208719.7
申请日：2010-05-20
IPC分类号： G01N33/50
摘要： This document is related to a method for determining the cardio-generative potential of mammalian cells which comprises the assessment of a CARdiac generation Potential Index (CARPI) as a function of the quantification of the expression of genes of said cells. It also relates to a method for quantitatively assessing the modification of this cardio-generative potential and the cardiogenic potential of a treatment aiming at cellular differentiation.
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公开(公告)号：EP2506867B1
公开(公告)日：2014-10-08
申请号：EP10790375.9
申请日：2010-12-02
IPC分类号： A61K38/18 , A61K38/30 , A61K38/48 , A61K38/22 , A61K38/19 , A61K31/529 , A61K45/06 , A61P9/10
CPC分类号： A61K31/529 , A61K9/0019 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61K38/19 , A61K38/22 , A61K38/30 , A61K45/06 , A61K47/02 , A61K2300/00
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5.发明公开METHOD FOR DETERMINING THE CARDIO-GENERATIVE POTENTIAL OF MAMMALIAN CELLS 审中-公开VERFAHREN ZUR BESTIMMUNG DES KARDIOGENERATIVEN POTENZIALS VONSÄUGERZELLEN
公开(公告)号：EP2433125A1
公开(公告)日：2012-03-28
申请号：EP10721224.3
申请日：2010-05-20
IPC分类号： G01N33/50
CPC分类号： C12N5/0657 , A61K35/34 , C12N2501/105 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/23 , C12N2501/734 , C12N2501/999 , C12N2506/1353 , C12Q1/6876 , C12Q1/6881 , C12Q2600/136 , C12Q2600/158 , G06F19/24
摘要： This document is related to a method for determining the cardio-generative potential of mammalian cells which comprises the assessment of a CARdiac generation Potential Index (CARPI) as a function of the quantification of the expression of genes of said cells. It also relates to a method for quantitatively assessing the modification of this cardio-generative potential and the cardiogenic potential of a treatment aiming at cellular differentiation.
摘要翻译： 本文件涉及用于确定哺乳动物细胞的心脏发生潜力的方法，其包括作为所述细胞的基因表达的定量的函数的CARdiac产生潜在指数（CARPI）的评估。 它还涉及一种定量评估这种心脏生成潜力的改变和针对细胞分化的治疗的心源性潜力的方法。
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6.发明公开INJECTION CATHETER FOR DELIVERING A THERAPEUTIC AGENT INTO A SUBSTRATE 有权INJEKTIONSKATHETER ZUR ABGABE EINES在EIN SUBSTRAT中治疗荨麻疹
公开(公告)号：EP2424606A1
公开(公告)日：2012-03-07
申请号：EP10719593.5
申请日：2010-04-29
CPC分类号： A61M25/007 , A61B2017/00247 , A61B2018/00392 , A61M5/158 , A61M25/0084 , A61M2005/1581 , A61M2025/009
摘要： The invention relates to an injection catheter for delivering a therapeutic agent into a substrate, comprising one or more lumens and a curved delivery element, said lumen serving as a guide for said curved delivery element outside of the substrate; said curved delivery element comprising openings on its distal tip, said distal tip comprising a distal zone and a proximal zone, said injection catheter being characterized in that the specific surface in said distal zone of said distal tip of said curved delivery element is higher than the specific surface in said proximal zone of said distal tip of said curved delivery element. The invention also relates to a process for delivering a therapeutic agent into a substrate.
摘要翻译： 本发明涉及一种用于将治疗剂递送到基底中的注射导管，其包括一个或多个内腔和弯曲的输送元件，所述内腔用作所述弯曲输送元件在基底外部的引导件; 所述弯曲的传送元件包括在其远侧末端上的开口，所述远侧末端包括远端区域和近端区域，所述注射导管的特征在于，所述弯曲递送元件的所述远端尖端的所述远端区域中的比表面高于 在所述弯曲传送元件的所述远端的所述近端区域中的比表面。 本发明还涉及将治疗剂递送到基质中的方法。
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公开(公告)号：EP2433125B1
公开(公告)日：2018-11-28
申请号：EP10721224.3
申请日：2010-05-20
IPC分类号： G01N33/50
CPC分类号： C12N5/0657 , A61K35/34 , C12N2501/105 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/23 , C12N2501/734 , C12N2501/999 , C12N2506/1353 , C12Q1/6876 , C12Q1/6881 , C12Q2600/136 , C12Q2600/158 , G06F19/24
摘要： This document is related to a method for determining the cardio-generative potential of mammalian cells which comprises the assessment of a CARdiac generation Potential Index (CARPI) as a function of the quantification of the expression of genes of said cells. It also relates to a method for quantitatively assessing the modification of this cardio-generative potential and the cardiogenic potential of a treatment aiming at cellular differentiation.
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9.发明公开PHARMACEUTICAL COMPOSITIONS FOR THE STIMULATION OF STEM CELLS. 有权药剂师ZUSAMMENSETZUNGEN ZUR STIMULATION VON STAMMZELLEN
公开(公告)号：EP2506867A1
公开(公告)日：2012-10-10
申请号：EP10790375.9
申请日：2010-12-02
CPC分类号： A61K31/529 , A61K9/0019 , A61K38/18 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61K38/19 , A61K38/22 , A61K38/30 , A61K45/06 , A61K47/02 , A61K2300/00
摘要： The invention relates to a human or veterinary pharmaceutical composition (B) for the stimulation of stem cells, comprising at least two stem-cells-stimulating- agents and at least one pharmaceutically acceptable excipient.
摘要翻译： 本发明涉及用于刺激干细胞的人或兽用药物组合物（B），其包含至少两种干细胞刺激剂和至少一种药学上可接受的赋形剂。
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