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1.发明公开METHOD FOR DETERMINING THE CARDIO-GENERATIVE POTENTIAL OF MAMMALIAN CELLS 审中-公开VERFAHREN ZUR BESTIMMUNG DES KARDIOGENERATIVEN POTENZIALS VONSÄUGERZELLEN
公开(公告)号：EP2433125A1
公开(公告)日：2012-03-28
申请号：EP10721224.3
申请日：2010-05-20
IPC分类号： G01N33/50
CPC分类号： C12N5/0657 , A61K35/34 , C12N2501/105 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/23 , C12N2501/734 , C12N2501/999 , C12N2506/1353 , C12Q1/6876 , C12Q1/6881 , C12Q2600/136 , C12Q2600/158 , G06F19/24
摘要： This document is related to a method for determining the cardio-generative potential of mammalian cells which comprises the assessment of a CARdiac generation Potential Index (CARPI) as a function of the quantification of the expression of genes of said cells. It also relates to a method for quantitatively assessing the modification of this cardio-generative potential and the cardiogenic potential of a treatment aiming at cellular differentiation.
摘要翻译： 本文件涉及用于确定哺乳动物细胞的心脏发生潜力的方法，其包括作为所述细胞的基因表达的定量的函数的CARdiac产生潜在指数（CARPI）的评估。 它还涉及一种定量评估这种心脏生成潜力的改变和针对细胞分化的治疗的心源性潜力的方法。
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公开(公告)号：EP2433125B1
公开(公告)日：2018-11-28
申请号：EP10721224.3
申请日：2010-05-20
IPC分类号： G01N33/50
CPC分类号： C12N5/0657 , A61K35/34 , C12N2501/105 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/23 , C12N2501/734 , C12N2501/999 , C12N2506/1353 , C12Q1/6876 , C12Q1/6881 , C12Q2600/136 , C12Q2600/158 , G06F19/24
摘要： This document is related to a method for determining the cardio-generative potential of mammalian cells which comprises the assessment of a CARdiac generation Potential Index (CARPI) as a function of the quantification of the expression of genes of said cells. It also relates to a method for quantitatively assessing the modification of this cardio-generative potential and the cardiogenic potential of a treatment aiming at cellular differentiation.
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公开(公告)号：EP3524980A1
公开(公告)日：2019-08-14
申请号：EP18208719.7
申请日：2010-05-20
IPC分类号： G01N33/50
摘要： This document is related to a method for determining the cardio-generative potential of mammalian cells which comprises the assessment of a CARdiac generation Potential Index (CARPI) as a function of the quantification of the expression of genes of said cells. It also relates to a method for quantitatively assessing the modification of this cardio-generative potential and the cardiogenic potential of a treatment aiming at cellular differentiation.
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公开(公告)号：EP1786471B1
公开(公告)日：2015-02-11
申请号：EP05777528.0
申请日：2005-07-29
发明人： TERZIC, Andre , BEHFAR, Atta
CPC分类号： A61K38/30 , A61K35/545 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61K38/204 , A61K38/2093 , A61K38/4833 , A61K2300/00
摘要： This document provides methods and materials for treating cardiovascular tissue. For example, stem cells, compositions containing stem cells, methods for obtaining stem cells, compositions for generating stem cells expressing particular markers, and methods for repairing cardiovascular tissue arc provided.
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公开(公告)号：EP3796944A1
公开(公告)日：2021-03-31
申请号：EP19806442.0
申请日：2019-05-23
发明人： BEHFAR, Atta , TERZIC, Andre
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公开(公告)号：EP2131868A1
公开(公告)日：2009-12-16
申请号：EP08731697.2
申请日：2008-03-07
发明人： TERZIC, Andre , BEHFAR, Atta , NELSON, Timothy J.
CPC分类号： C12N5/0657 , C12N2501/25 , C12N2506/02
摘要： This document provides methods and materials related to treating cardiovascular tissue (e.g., heart tissue or vascular tissue). For example, stem cells (e.g., CXCR4+/Flk-1+ stem cells), compositions containing stem cells, methods for obtaining stem cells, and methods for repairing cardiovascular tissue are provided.
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公开(公告)号：EP2315829B1
公开(公告)日：2015-02-11
申请号：EP09805666.6
申请日：2009-08-10
发明人： IKEDA, Yasuhiro , TERZIC, Andre , NELSON, Timothy, J. , MAEL, Amber, A. , FERNANDEZ, Almudena J. Martinez , YAMADA, Satsuki
CPC分类号： C12N5/0696 , A61K35/12 , C12N2500/90 , C12N2500/98 , C12N2501/602 , C12N2501/603 , C12N2501/604 , C12N2501/605 , C12N2501/606 , C12N2501/608 , C12N2510/00 , C12N2740/16043
摘要： This document provides methods and materials related to induced pluripotent stem cells. For example, induced pluripotent stem cells, compositions containing induced pluripotent stem cells, methods for obtaining induced pluripotent stem cells, and methods for using induced pluripotent stem cells are provided. In addition, methods and materials for using induced pluripotent stem cells to repair tissue (e.g., cardiovascular tissue) in vivo as well as methods and materials for using induced pluripotent stem cells to assess their therapeutic potential in appropriate animal models are provided.
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公开(公告)号：EP2303310A2
公开(公告)日：2011-04-06
申请号：EP09763198.0
申请日：2009-05-20
发明人： TERZIC, Andre , BEHFAR, Atta
CPC分类号： C12N5/0657 , A61K31/505 , A61K31/529 , A61K35/28 , A61K35/34 , A61K38/1825 , A61K38/1841 , A61K38/1866 , A61K38/1875 , A61K38/19 , A61K38/22 , A61K38/30 , A61K38/4833 , C12N2501/105 , C12N2501/115 , C12N2501/15 , C12N2501/155 , C12N2501/16 , C12N2501/175 , C12N2501/70 , C12N2501/734 , C12N2501/999 , C12N2506/1353 , A61K2300/00
摘要： This document relates to compositions containing cardiogenic factors, to methods to obtain cells by culturing initial cells in the presence of such factors; and methods of administering the obtained cells to heart tissue.
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公开(公告)号：EP1786471A2
公开(公告)日：2007-05-23
申请号：EP05777528.0
申请日：2005-07-29
发明人： TERZIC, Andre , BEHFAR, Atta
IPC分类号： A61K48/00
CPC分类号： A61K38/30 , A61K35/545 , A61K38/1825 , A61K38/1841 , A61K38/1875 , A61K38/204 , A61K38/2093 , A61K38/4833 , A61K2300/00
摘要： This document provides methods and materials for treating cardiovascular tissue. For example, stem cells, compositions containing stem cells, methods for obtaining stem cells, compositions for generating stem cells expressing particular markers, and methods for repairing cardiovascular tissue arc provided.
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公开(公告)号：EP4244384A1
公开(公告)日：2023-09-20
申请号：EP21892693.9
申请日：2021-11-10
发明人： TERZIC, Andre , BEHFAR, Atta
IPC分类号： C12Q1/6827 , C12Q1/6883
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