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公开(公告)号：EP2838533A1
公开(公告)日：2015-02-25
申请号：EP13779034.1
申请日：2013-04-16
申请人： Case Western Reserve University , Board of Regents of the University of Texas System , University of Kentucky
发明人： MARKOWITZ, Sanford , WILLSON, James, K.V. , POSNER, Bruce, A. , READY, Joseph , ZHANG, Yongyou , TAI, Hsin-Hsiung , MOSS, Melissa , ANTCZAK, Monika , GERSON, Stanton , DESAI, Amar , BAE, Kibeom , YANG, Sung Yeun
IPC分类号： A61K31/4365 , A61K31/4462 , C07D495/04 , A61P17/02 , A61P29/00
CPC分类号： C07D495/04 , A61K31/4365 , A61K31/519 , C07C311/21 , C07C2601/14 , C07D207/263 , C07D209/08 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07D277/46 , C07D295/185 , C07D405/12
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
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公开(公告)号：EP3295940A1
公开(公告)日：2018-03-21
申请号：EP17194305.3
申请日：2013-04-16
申请人： Case Western Reserve University , Board Of Regents Of the University Of Texas System , University of Kentucky
发明人： MARKOWITZ, Sanford , WILLSON, James K. V. , POSNER, Bruce A. , READY, Joseph , ZHANG, Yongyou , TAI, Hsin-Hsiung , MOSS, Melissa , ANTCZAK, Monika , GERSON, Stanton , DESAI, Amar , BAE, Kibeom , YANG, Sung Yeun
IPC分类号： A61K31/4365 , A61K31/4462 , C07D495/04 , A61P17/02 , A61P29/00
CPC分类号： C07D495/04 , A61K31/4365 , A61K31/519 , C07C311/21 , C07C2601/14 , C07D207/263 , C07D209/08 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07D277/46 , C07D295/185 , C07D405/12
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
摘要翻译： 调节15-PGDH活性，调节组织前列腺素水平，治疗疾病，疾病病症或期望调节15-PGDH活性和/或前列腺素水平的病症的化合物和方法包括所述的15-PGDH抑制剂和15-PGDH活化剂 于此。
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公开(公告)号：EP2838533B1
公开(公告)日：2017-10-04
申请号：EP13779034.1
申请日：2013-04-16
申请人： Case Western Reserve University , Board of Regents of the University of Texas System , University of Kentucky
发明人： MARKOWITZ, Sanford , WILLSON, James, K.V. , POSNER, Bruce, A. , READY, Joseph , ZHANG, Yongyou , TAI, Hsin-Hsiung , MOSS, Melissa , ANTCZAK, Monika , GERSON, Stanton , DESAI, Amar , BAE, Kibeom , YANG, Sung Yeun
IPC分类号： A61K31/4365 , A61K31/4462 , C07D495/04 , A61P17/02 , A61P29/00
CPC分类号： C07D495/04 , A61K31/4365 , A61K31/519 , C07C311/21 , C07C2601/14 , C07D207/263 , C07D209/08 , C07D213/71 , C07D213/73 , C07D213/75 , C07D213/76 , C07D215/08 , C07D237/20 , C07D239/42 , C07D241/20 , C07D261/14 , C07D275/03 , C07D277/46 , C07D295/185 , C07D405/12
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors and 15-PGDH activators described herein.
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公开(公告)号：EP3883577A1
公开(公告)日：2021-09-29
申请号：EP19887392.9
申请日：2019-11-21
申请人： CASE WESTERN RESERVE UNIVERSITY , Board Of Regents Of the University Of Texas System , Rodeo Therapeutics Corporation
IPC分类号： A61K31/519 , A61K31/505 , C07D417/04 , C07D495/02 , C07D495/04
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5.发明公开COMPOSITIONS AND METHODS OF MODULATING SHORT-CHAIN DEHYDROGENASE ACTIVITY 审中-公开ZUSAMMENSETZUNGEN UND VERFAHREN ZUR MODULATION DERAKTIVITÄTKURZKETTIGER DEHYDROGENASE
公开(公告)号：EP3057973A1
公开(公告)日：2016-08-24
申请号：EP14859042.5
申请日：2014-10-15
发明人： MARKOWITZ, Sanford , WILLSON, James K.V. , POSNER, Bruce , READY, Joseph , ANTCZAK, Monika , ZHANG, Yongyou , DESAI, Amar , GERSON, Stanton , GREENLEE, William
IPC分类号： C07D495/04 , A61K31/4743
CPC分类号： A61K31/5377 , A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/496 , A61K31/519 , C07D495/04
摘要： Compounds and methods of modulating 15-PGDH activity, modulating tissue prostaglandin levels, treating disease, diseases disorders, or conditions in which it is desired to modulate 15-PGDH activity and/or prostaglandin levels include 15-PGDH inhibitors described herein.
摘要翻译： 调节15-PGDH活性，调节组织前列腺素水平，治疗疾病，疾病障碍或期望调节15-PGDH活性和/或前列腺素水平的病症的化合物和方法包括本文所述的15-PGDH抑制剂。
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公开(公告)号：EP3057973B1
公开(公告)日：2019-09-04
申请号：EP14859042.5
申请日：2014-10-15
发明人： MARKOWITZ, Sanford , WILLSON, James K.V. , POSNER, Bruce , READY, Joseph , ANTCZAK, Monika , ZHANG, Yongyou , DESAI, Amar , GERSON, Stanton , GREENLEE, William
IPC分类号： C07D495/04 , A61P19/00 , A61K31/4365
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公开(公告)号：EP4192455A1
公开(公告)日：2023-06-14
申请号：EP21852905.5
申请日：2021-08-09
申请人： CASE WESTERN RESERVE UNIVERSITY , The United States Government as Represented by the Department of Veterans Affairs , University of Texas Southwestern Medical Center
发明人： MARKOWITZ, Sanford , PIEPER, Andrew , LI, Hongyun , READY, Joseph , SHIN, Min-Kyoo , KOH, Yeojung , ROSA, Edwin Vazquez
IPC分类号： A61K31/4365 , A61K31/519 , A61P25/00 , A61P25/28
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8.发明公开
公开(公告)号：EP3484473A1
公开(公告)日：2019-05-22
申请号：EP17831696.4
申请日：2017-07-18
申请人： Case Western Reserve University , The University of Texas Southwestern Medical center , University Of Iowa Research Foundation
IPC分类号： A61K31/4365 , A61K31/18 , C07D495/04
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9.发明公开
公开(公告)号：EP3548035A1
公开(公告)日：2019-10-09
申请号：EP17877310.7
申请日：2017-11-30
IPC分类号： A61K31/56 , A61K31/4743 , A61P17/02 , C07D495/04
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公开(公告)号：EP2417270B1
公开(公告)日：2017-09-20
申请号：EP10762298.7
申请日：2010-04-06
发明人： VOGELSTEIN, Bert , KINZLER, Kenneth, W. , LI, Meng , DIAZ, Luis , PAPADOPOULOS, Nickolas , MARKOWITZ, Sanford
CPC分类号： C12Q1/6816 , C12Q1/6886 , C12Q2600/154 , C12Q2565/501 , C12Q2527/125 , C12Q2523/125
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