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    THERAPY PLANNING
    4.
    发明公开
    THERAPY PLANNING 有权
    THERAPIEPLANUNG

    公开(公告)号：EP3030317A1

    公开(公告)日：2016-06-15

    申请号：EP14771386.1

    申请日：2014-07-29

    申请人： Koninklijke Philips N.V. ,  The University of Texas Southwestern Medical center

    发明人： BHARAT, Shyam ,  GOPALAKRISHNAN, Sankara Hari ,  SAWANT, Amit Ramakant

    IPC分类号： A61N5/10

    CPC分类号： A61N5/1037 ,  A61N5/1039 ,  A61N5/1067

    摘要： When reducing radiation dose to healthy tissue near a target volume, a 4D motion model (52) of a target volume is generated during CT scan data acquisition. The target volume is tracked, and tracked target volume position information (43) is provided to a motion estimation tool (48). Motion parameter information (60) output from the motion estimation tool is linked to motion phases of the target volume indicated by CT scan data. A dynamic planned target volume (PTV) (64) that covers the target volume in each motion phase is generated and linked to tracked motion parameters for each respective motion phase. A radiation dose is delivered to the PTV for each motion phase using the linked motion parameters and real-time tracking information.

    METHOD OF TREATING HAIR LOSS USING SULFONYL THYROMIMETIC COMPOUNDS
    6.
    发明公开
    METHOD OF TREATING HAIR LOSS USING SULFONYL THYROMIMETIC COMPOUNDS 审中-公开
    方法脱发的治疗中使用甲磺酰基含拟甲状腺素CONNECTIONS

    公开(公告)号：EP1185232A1

    公开(公告)日：2002-03-13

    申请号：EP00915939.3

    申请日：2000-03-01

    申请人： UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER

    发明人： ZHANG, Lilly, Li-Xin ,  YOUNGQUIST, Robert, Scott

    IPC分类号： A61K7/06

    CPC分类号： A61Q7/00 ,  A61K8/46 ,  A61K8/4953

    摘要： A method of treating hair loss comprising administering a composition comprising a cardiac-sparing compound characterized by structure (I) and pharmaceutically acceptable salts, hydrates, and biohydrolyzable amides, esters, and imides thereof, wherein: R1 is -(CH2)n(CHNR7R8)mC(O)R9; n is an integer from 1 to 3; m is an integer from 0 to 1; R3 and R5 are each, independently, selected from the group consisting of chlorine, bromine, iodine, and -CH3, R7 and R8 are each, independently, selected from the group consisting of hydrogen and C1-C4 alkyl; R9 is selected from the group consisting of hydroxy, C1-C4 alkoxy, and -NR7R8; R31 is selected from the group consisting of hydrogen, chlorine, bromine, iodine, C1-C4 alkyl, C4-C6 cycloalkyl, C1-C4 haloalkyl, C4-C6 halocycloalkyl, and -CH(R10)Ar; Ar is selected from the group consisting of 5-hydroxypyrid-2-yl, 6-hydroxypyrid-3-yl, 6-hydroxypyridazin-3-yl, 6-methoxypyridazin-3-yl N-oxide, and 6-hydroxypyridazin-3-yl N-oxide; R10 is selected from the group consisting of hydrogen and C1-C4 alkyl; and R41 is selected from the group consisting of hydroxy and C1-C4 alkoxy.

    METHOD OF IMPROVED MULTIPLE-PHASE DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING
    9.
    发明公开
    METHOD OF IMPROVED MULTIPLE-PHASE DYNAMIC CONTRAST-ENHANCED MAGNETIC RESONANCE IMAGING 审中-公开
    VERFAHREN ZUR VERBESSERTEN MULTIPHASEN-MAGNETRESONANZBILDGEBUNG MIT DYNAMISCHERKONTRASTVERSTÄRKUNG

    公开(公告)号：EP3131458A1

    公开(公告)日：2017-02-22

    申请号：EP15718101.7

    申请日：2015-03-31

    申请人： Koninklijke Philips N.V. ,  The University of Texas Southwestern Medical Center

    发明人： GDANIEC, Nadine ,  BOERNERT, Peter ,  DONEVA, Mariya Ivanova ,  PEDROSA, Ivan

    IPC分类号： A61B5/00 ,  A61B5/055 ,  A61B6/00

    摘要： A method of operating a magnetic resonance imaging system (10) with regard to acquiring multiple-phase dynamic contrast-enhanced magnetic resonance images, the method comprising steps of acquiring (48) a first set of magnetic resonance image data (xpre) prior to administering a contrast agent to the subject of interest (20), by employing a water/fat magnetic resonance signal separation technique, determining (52) a first image of the spatial distribution of fat (Ipre) of at least the portion of the subject of interest (20), acquiring (50) at least a second set of magnetic resonance image data (x2) of at least the portion of the subject of interest (20) after administering the contrast agent to the subject of interest (20), by employing a water/fat magnetic resonance signal separation technique, determining (54) at least a second image of the spatial distribution of fat (I2ph) of at least the portion of the subject of interest (20), applying (56) an image registration method to the second image of the spatial distribution of fat with reference to the first image of the spatial distribution of fat (Ipre) for correcting a potential motion of the subject of interest (20); and a magnetic resonance imaging system (10) having a control unit (26) that is configured to carry out steps (56-64) of such a method; and a software module (44) for carrying out such a method, wherein the method steps (56-64) to be conducted are converted into a program code that is implementable in a memory unit (30) and is executable by a processor unit (32) of the magnetic resonance imaging system (10).

    摘要翻译： 一种在获取多相动态对比度增强磁共振图像时操作磁共振成像系统（10）的方法，所述方法包括以下步骤：在施用之前获取（48）第一组磁共振图像数据（xpre） 通过使用水/脂肪磁共振信号分离技术来确定（52）至少感兴趣的对象的部分的脂肪的空间分布（Ipre）的第一图像（52），所述目标对象的造影剂（20） （20），通过采用（50）至少所述感兴趣对象的部分（20）的至少第二组磁共振图像数据（x2），所述至少一部分感兴趣的对象的主体（20） 水分/脂肪磁共振信号分离技术，确定（54）至少所述感兴趣对象部分（20）的脂肪（I2ph）的空间分布的至少第二图像，应用（56）图像配准方法 到seco 参考脂肪空间分布的第一图像（Ipre）来修正感兴趣对象的潜在运动（20）的脂肪的空间分布的图像; 以及具有控制单元（26）的磁共振成像系统（10），所述控制单元被配置为执行这种方法的步骤（56-64）; 以及用于执行这种方法的软件模块（44），其中要执行的方法步骤（56-64）被转换为可在存储器单元（30）中实现的程序代码，并且可由处理器单元 32）的磁共振成像系统（10）。