公开(公告)号：EP2436387B1

公开(公告)日：2018-07-25

申请号：EP10780502.0

申请日：2010-05-24

申请人： Celgene Corporation

发明人： HANDA, Hiroshi ,  ANDO, Hideki ,  ITO, Takumi ,  HOTTA, Kentaro

IPC分类号： A61K35/12 ,  A61K35/30 ,  A61K35/76 ,  A61K38/45 ,  A61K48/00 ,  A61P25/28 ,  C12Q1/02 ,  C12Q1/25 ,  C12N5/10 ,  C12N9/00 ,  C12N15/09 ,  G01N33/50

CPC分类号： C12N9/48 ,  A61K38/00 ,  A61K38/45 ,  C07K14/4705 ,  C07K14/475 ,  C07K19/00 ,  C07K2319/43 ,  C12N9/93 ,  C12Y304/00 ,  C12Y603/02019 ,  G01N33/5058 ,  G01N2500/04 ,  G01N2800/28

摘要： With an aim to provide a novel factor inducing proliferation of neural stem cells and differentiation of these cells into nerve cells, a pharmaceutical composition comprising 1) CRBN, 2) a nucleic acid encoding CRBN, or 3) a stem cell or a neural progenitor cell in which CRBN is expressed, a method including administering the pharmaceutical composition to a non-human animal and inducing proliferation of neural stem cells or neural progenitor cells of the non-human animal and differentiation of these cells into nerve cells, and a method for screening for a therapeutic drug for a disease of cerebral cortex or a surgical injury of cerebral cortex, using CRBN, are provided.