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公开(公告)号：EP3695713A1
公开(公告)日：2020-08-19
申请号：EP19217255.9
申请日：2013-10-31
申请人： Cellectis , Medicago Inc.
发明人： VOYTAS, Daniel F. , MATHIS, Luc , LI, Jin , ZHANG, Feng , STODDARD, Thomas , D'AOUST, Marc-Andre
摘要： Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.
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公开(公告)号：EP2914094A1
公开(公告)日：2015-09-09
申请号：EP13789460.6
申请日：2013-10-31
申请人： CELLECTIS , Medicago Inc.
发明人： VOYTAS, Daniel F. , MATHIS, Luc , LI, Jin , ZHANG, Feng , STODDARD, Thomas , D'AOUST, Marc-Andre
CPC分类号： A01H5/12 , A01H1/06 , C12N9/22 , C12N15/01 , C12N15/8218 , C12N15/8257 , C12N15/8258 , C12P21/00 , C12P21/005
摘要： Materials and methods are provided for making plants (e.g., Nicotiana varieties) that are suitable for producing therapeutic polypeptides suitable for administration to humans and animals, particularly by making TAL effector endonuclease-induced mutations in genes encoding xylosyltransferases and fucosyltransferases.
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公开(公告)号：EP3765618A1
公开(公告)日：2021-01-20
申请号：EP19767538.2
申请日：2019-03-14
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公开(公告)号：EP3256575B1
公开(公告)日：2020-07-29
申请号：EP16739705.8
申请日：2016-01-21
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公开(公告)号：EP2635684B1
公开(公告)日：2016-10-26
申请号：EP11837364.6
申请日：2011-11-03
申请人： Medicago Inc.
IPC分类号： C07K14/005 , C12N15/82
CPC分类号： C07K14/005 , C12N15/8203 , C12N15/8216 , C12N15/8221 , C12N15/8257 , C12N15/8258 , C12N2750/12022 , C12N2760/16051 , C12N2770/18022 , C12N2820/60 , C12N2830/60
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公开(公告)号：EP2445928A1
公开(公告)日：2012-05-02
申请号：EP10791119.0
申请日：2010-06-25
申请人： Medicago Inc.
发明人： COUTURE, Manon , DARGIS,Michele , LAVOIE, Pierre-Olivier , VEZINA, Louis-Philippe , D'AOUST, Marc-Andre
IPC分类号： C07K14/11 , A01H5/00 , A61K39/145 , A61P31/16 , C12N15/44 , C12N15/82 , C12N7/00 , C12N7/01 , C07K19/00
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/5258 , C07K14/005 , C07K2319/00 , C07K2319/02 , C12N15/8257 , C12N2760/16122 , C12N2760/16123 , C12N2760/16134 , C12N2760/16222 , C12N2760/16223 , C12N2760/16234
摘要： A method for synthesizing chimeric influenza virus-like particles (VLPs) within a plant or a portion of a plant is provided. The method involves expression of chimeric influenza HA in a plant or a portion of a plant. The invention is also directed towards a VLP comprising chimeric influenza HA protein and plants lipids. The invention is also directed to a nucleic acid encoding chimeric influenza HA as well as vectors. The VLPs may be used to formulate influenza vaccines, or may be used to enrich existing vaccines.
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8.发明公开
公开(公告)号：EP4139331A1
公开(公告)日：2023-03-01
申请号：EP21793274.8
申请日：2021-04-22
申请人： Medicago Inc. , Hendin, Hilary E. , Ward, Brian J.
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公开(公告)号：EP2480560B1
公开(公告)日：2018-02-21
申请号：EP10818191.8
申请日：2010-09-21
申请人： Medicago Inc.
CPC分类号： A61K39/145 , A61K39/12 , A61K2039/517 , A61K2039/5258 , C12N7/00 , C12N15/8203 , C12N15/8257 , C12N15/8258 , C12N2760/16123 , C12N2760/16134
摘要： Methods of preparing plant-derived virus like particles (VLPs) are provided. The method may comprise obtaining a plant, or plant matter comprising apoplast-localized VLPs, producing a protoplast/spheroplast fraction and apoplast fraction from the plant or plant matter, and recovering the apoplast fraction. The apoplast fraction comprises plant-derived VLPs. Alternatively, VLPs may be obtained from plant or plant matter comprising plant-derived VLPs by digesting the plant matter using a cell wall degrading enzyme composition to produced a digested fraction. The digested fraction is filtered to produced a filtered fraction, and the plant-derived VLPs are recovered from the filtered fraction.
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公开(公告)号：EP2847324B1
公开(公告)日：2018-01-03
申请号：EP13787880.7
申请日：2013-05-10
发明人： D'AOUST, Marc-Andre , LANDRY, Nathalie , LAVOIE, Pierre-Olivier , ARAI, Masaaki , ASAHARA, Naomi , MUTEPFA, David Levi Rutendo , HITZEROTH, Inga Isabel , RYBICKI, Edward Peter
CPC分类号： A61K39/15 , A61K39/12 , A61K2039/5258 , C07K14/005 , C12N7/00 , C12N7/02 , C12N15/8203 , C12N15/8214 , C12N15/8216 , C12N15/8218 , C12N15/8221 , C12N15/8258 , C12N2720/12334 , C12N2720/12351
摘要： A method of producing a virus-like particle (VLP) in a plant is provided. The method comprises introducing a first nucleic acid into the plant, or portion of the plant. The first nucleic acid comprising a first regulatory region active in the plant operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein for example but not limited to rotavirus protein VP2. The nucleotide sequence may further comprise one or more than one amplification element and/or a compartment targeting sequence. A second nucleic acid might be introduced into the plant, or portion of the plant. The second nucleic acid comprises a second regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP6. Optionally, a third nucleic acid and/ or fourth nucleic acid might be introduced into the plant, or portion of the plant. The third nucleic acid comprises a third regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP4. The fourth nucleic acid comprises a fourth regulatory region active in the plant and operatively linked to a nucleotide sequence encoding one or more rotavirus structural protein, for example but not limited to rotavirus protein VP7. The plant or portion of the plant is incubated under conditions that permit the expression of the nucleic acids, thereby producing the VLP.
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