公开(公告)号：EP4069258A1

公开(公告)日：2022-10-12

申请号：EP20829756.4

申请日：2020-12-04

申请人： Celularity Inc. ,  Sorrento Therapeutics, Inc.

发明人： KARASIEWICZ-MENDEZ, Kathy ,  HE, Shuyang ,  TESS, Kristina ,  LING, Weifang ,  JHUN, Kevin ,  ZELDIS, Jerome, B. ,  HARIRI, Robert J. ,  ZHANG, Xiaokui ,  MA, Qiangzhong ,  GUO, Wenzhong ,  ZHANG, Yanliang ,  JI, Henry Hongjun

IPC分类号： A61K35/17 ,  C07K14/725 ,  C12N5/073 ,  C12N5/0783 ,  C12N15/867

公开(公告)号：EP3524253A1

公开(公告)日：2019-08-14

申请号：EP18215553.1

申请日：2008-09-29

申请人： Celularity, Inc.

发明人： ZHANG, Xiaokui ,  VOSKINARIAN-BERSE, Vanessa ,  KANG, Lin ,  PADLINA, Neerav Dilip

IPC分类号： A61K35/50 ,  A61P35/00

摘要： The invention provides placental perfusate cells, CD56 + , CD16 - placental intermediate natural killer cells, and combinations of natural killer cells isolated from placental perfusate and natural killer cells isolated from umbilical cord blood which is isolated from the placenta from which said placental perfusate is obtained. Further provided herein are such cells and cell combinations for use in a method of suppressing the proliferation of tumor cells, in particular for the treatment of an individual having a tumor. Also provided herein are composition comprising isolated CD56 + , CD16 - natural killer cells which are isolated from placental perfusate and wherein the natural killer cells comprise at least 50% of cells in the composition.

公开(公告)号：EP2938196B1

公开(公告)日：2019-04-03

申请号：EP13862498.6

申请日：2013-12-13

申请人： Celularity, Inc.

发明人： ZHANG, Xiaokui ,  ABBOT, Stewart ,  VOSKINARIAN-BERSE, Vanessa

IPC分类号： A01N63/00 ,  C12N15/00 ,  C12N5/02

公开(公告)号：EP3887364A1

公开(公告)日：2021-10-06

申请号：EP19827981.2

申请日：2019-11-29

申请人： Celularity Inc.

发明人： HARIRI, Robert J. ,  ZHANG, Xiaokui ,  EDINGER, James

IPC分类号： C07D401/14 ,  C07D409/04 ,  C07D487/04 ,  C07D491/04 ,  C07D495/04 ,  A61P43/00 ,  A61K31/506 ,  A61K31/519 ,  A61K31/4985

公开(公告)号：EP3622960A1

公开(公告)日：2020-03-18

申请号：EP19185231.8

申请日：2014-02-04

申请人： Celularity, Inc.

发明人： ZHANG, Xiaokui ,  HARIRI, Robert J. ,  VOSKINARIAN-BERSE, Vanessa ,  KANG, Lin ,  LAW, Eric ,  ABBOT, Stewart

IPC分类号： A61K35/17 ,  A61K35/50 ,  A61P37/08 ,  A61K31/454

摘要： Provided herein are placental perfusate, placental perfusate cells, placenta-derived intermediate natural killer cells, combined natural killer cells from placenta and umbilical cord blood, and combinations thereof. Also provided herein are compositions comprising the same, and methods of using placental perfusate, placental perfusate cells, placenta-derived intermediate natural killers cells, and combined natural killer cells and combinations thereof, to suppress the growth or proliferation of tumor cells, cancer cells, and the like, and to treat individuals having tumor cells. Also provided herein are methods of treating an individual having a tumor or graft-versus-host disease with placental perfusate, placental perfusate-derived cells, natural killer cells from placenta, e.g. from placental perfusate, and/or combined natural killer cells comprising natural killer cells from placenta, e.g., from placental perfusate, and umbilical cord blood.

公开(公告)号：EP2783692B1

公开(公告)日：2019-01-02

申请号：EP13188706.9

申请日：2008-09-29

申请人： Celularity, Inc.

发明人： ZHANG, Xiaokui ,  VOSKINARIAN-BERSE, Vanessa A. ,  KANG, Lin ,  PADLINA, Neerav Dilip

IPC分类号： A61K35/50 ,  A61K35/17 ,  C12N5/0783

公开(公告)号：EP3986381A1

公开(公告)日：2022-04-27

申请号：EP20742527.3

申请日：2020-06-19

申请人： Celularity Inc.

发明人： HARIRI, Robert J. ,  ZHANG, Xiaokui ,  YE, Qian ,  HE, Shuyang ,  HARIRI, Haley M. ,  SHAH, Navjot ,  SOMANCHI, Srinivas ,  STOUT, Bhavani

IPC分类号： A61K9/127 ,  A61K9/50 ,  A61K35/00 ,  A61K35/50 ,  A61K45/06 ,  A61K51/12 ,  A61P1/00 ,  A61P1/16 ,  A61P3/00 ,  A61P7/00 ,  A61P9/00 ,  A61P9/10 ,  A61P11/00 ,  A61P13/12 ,  A61P17/00 ,  A61P27/02 ,  C12N15/113 ,  C12N15/88

公开(公告)号：EP3887508A1

公开(公告)日：2021-10-06

申请号：EP19827982.0

申请日：2019-11-29

申请人： Celularity Inc.

发明人： HARIRI, Robert J. ,  ZHANG, Xiaokui ,  KANG, Lin ,  VAN DER TOUW, William ,  VOSKINARIAN-BERSE, Vanessa ,  GUO, Xuan

IPC分类号： C12N5/0783

公开(公告)号：EP2411506B1

公开(公告)日：2018-11-07

申请号：EP10722830.6

申请日：2010-03-26

申请人： Celularity, Inc.

发明人： ZHANG, Xiaokui ,  KANG, Lin ,  HEIDARAN, Mohammad ,  JASKO, Steven ,  ZEITLIN, Andy ,  PAL, Ajai ,  HARIRI, Robert, J.

IPC分类号： C12N5/0783 ,  A61K35/50 ,  A61P35/00 ,  A61K35/12

CPC分类号： C12N5/0646 ,  A61K2035/124

摘要： Provided herein are methods of suppressing tumor cell proliferation, of treating individuals having cancer or a viral infection, comprising contacting the tumor cells, or administering to the individual, placental perfusate, placental perfusate cells, or natural killer cells, e.g., placenta-derived intermediate natural killer cells, with an immunomodulatory compound or thalidomide.

公开(公告)号：EP3882336A1

公开(公告)日：2021-09-22

申请号：EP21158243.2

申请日：2014-03-13

申请人： Celularity Inc.

发明人： ABBOT, Stewart ,  KARASIEWICZ-MENDEZ, Kathy ,  ZHANG, Xiaokui

IPC分类号： C12N5/00 ,  C12N5/02

摘要： Provided herein are placental stem cells that exhibit increased survival ("enhanced placental stem cells"), compositions comprising such placental stem cells, and methods of using such placental stem cells and compositions.