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公开(公告)号：EP2471907B1
公开(公告)日：2018-09-26
申请号：EP12150934.3
申请日：2006-12-28
申请人： Celularity, Inc.
发明人： ABRAMSON, Sascha Dawn , EDINGER, James W. , FALECK, Herbert , HARIRI, Robert J. , LABAZZO, Kristen S. , PEREIRA, Marian , WANG, Jia-Lun , YE, Qian
IPC分类号： A61K38/21 , A61K35/644 , A61K9/00 , C12N5/073 , C12N5/074 , A61K45/06 , A61K35/50 , A61K35/12
CPC分类号： A61K35/50 , A61K9/0019 , A61K35/644 , A61K38/21 , A61K45/06 , A61K2035/122 , C12N5/0605 , C12N5/0607 , C12N2500/25 , C12N2500/36 , C12N2500/42 , C12N2501/11 , C12N2501/135 , C12N2501/39 , C12N2533/52 , A61K2300/00
摘要： The present invention provides placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. The invention also provides methods of differentiating the placental stem cells. The invention further provides methods of using the placental stem cells in assays and for transplanting.
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公开(公告)号：EP2084268B1
公开(公告)日：2018-09-26
申请号：EP07867275.5
申请日：2007-10-23
申请人： Celularity, Inc.
发明人： EDINGER, James W. , HARIRI, Robert J. , WANG, Jia-Lun , YE, Qian , LABAZZO, Kristen S. , PEREIRA, Marian , ABRAMSON, Sascha Dawn
CPC分类号： A61K35/50 , A61K9/0019 , A61K35/12 , A61K47/36 , A61K47/42 , A61L27/3834 , A61L27/3847 , C12N5/0605 , C12N5/0654 , C12N5/0668 , C12N2500/38 , C12N2500/42 , C12N2501/39 , C12N2506/025 , C12N2506/03 , C12N2533/18 , C12N2533/54
摘要： Provided herein are methods of using adherent placental stem cells and placental stem cell populations, and methods of culturing, proliferating and expanding the same. Also provided herein are methods of differentiating the placental stem cells. Further provided herein are methods of using the placental stem cells to formulate implantable or injectable compositions suitable for administration to a subject. Still further provided herein are provides methods for treating bone defects with stem cells and compositions comprising stem cells.
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公开(公告)号：EP3886876A1
公开(公告)日：2021-10-06
申请号：EP19828010.9
申请日：2019-12-02
申请人： Celularity Inc.
IPC分类号： A61K35/17 , C07K14/725 , C12N5/0783 , C12N15/63 , C12N5/073
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4.发明授权
公开(公告)号：EP3088512B1
公开(公告)日：2019-12-11
申请号：EP16160000.2
申请日：2011-04-06
申请人： Celularity, Inc.
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公开(公告)号：EP2305795B1
公开(公告)日：2019-07-03
申请号：EP10183378.8
申请日：2001-12-05
申请人： Celularity, Inc.
发明人： HARIRI, Robert J.
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公开(公告)号：EP3562492A1
公开(公告)日：2019-11-06
申请号：EP17886775.0
申请日：2017-12-28
申请人： Celularity, Inc.
发明人： ZHANG, Xiaokui , YE, Qian , LI, Tianjian , WANG, Chuan , BHARATHAN, Mini , HERZBERG, Uri , HARIRI, Robert J.
IPC分类号： A61K35/17 , C12N5/00 , C12N15/113 , C12N15/85
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公开(公告)号：EP3362075A1
公开(公告)日：2018-08-22
申请号：EP16856249.4
申请日：2016-10-14
申请人： CELULARITY, INC.
发明人： ZHANG, Xiaokui , DJURETIC, Ivana , KANG, Lin , VOSKINARIAN-BERSE, Vanessa , STOUT, Bhavani , HARIRI, Robert J. , HOFGARTNER, Wolfgang , EDINGER, James , LAW, Eric , JANKOVIC, Vladimir
IPC分类号： A61K35/17 , A61P35/00 , C12N5/0783
CPC分类号： C12N5/0646 , A61K35/17 , C12N5/0634 , C12N2501/125 , C12N2501/22 , C12N2501/2302 , C12N2501/2306 , C12N2501/2307 , C12N2501/2315 , C12N2501/30 , C12N2501/999 , C12N2506/03
摘要： Provided herein are methods of producing natural killer (NK) cells and/or ILC3 cells using a three-stage expansion and differentiation method with media comprising stem cell mobilizing factors. Also provided herein are methods of suppressing tumor cell proliferation using the NK cells and/or ILC3 cells and the NK cell and/or ILC3 cell populations produced by the three-stage methods described herein, as well as methods of treating individuals having cancer or a viral infection, comprising administering the NK cells and/or ILC3 cells and the NK cell and/or ILC3 cell populations produced by the three-stage methods described herein to an individual having the cancer or viral infection.
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公开(公告)号：EP3887364A1
公开(公告)日：2021-10-06
申请号：EP19827981.2
申请日：2019-11-29
申请人： Celularity Inc.
IPC分类号： C07D401/14 , C07D409/04 , C07D487/04 , C07D491/04 , C07D495/04 , A61P43/00 , A61K31/506 , A61K31/519 , A61K31/4985
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公开(公告)号：EP3622960A1
公开(公告)日：2020-03-18
申请号：EP19185231.8
申请日：2014-02-04
申请人： Celularity, Inc.
发明人： ZHANG, Xiaokui , HARIRI, Robert J. , VOSKINARIAN-BERSE, Vanessa , KANG, Lin , LAW, Eric , ABBOT, Stewart
IPC分类号： A61K35/17 , A61K35/50 , A61P37/08 , A61K31/454
摘要： Provided herein are placental perfusate, placental perfusate cells, placenta-derived intermediate natural killer cells, combined natural killer cells from placenta and umbilical cord blood, and combinations thereof. Also provided herein are compositions comprising the same, and methods of using placental perfusate, placental perfusate cells, placenta-derived intermediate natural killers cells, and combined natural killer cells and combinations thereof, to suppress the growth or proliferation of tumor cells, cancer cells, and the like, and to treat individuals having tumor cells. Also provided herein are methods of treating an individual having a tumor or graft-versus-host disease with placental perfusate, placental perfusate-derived cells, natural killer cells from placenta, e.g. from placental perfusate, and/or combined natural killer cells comprising natural killer cells from placenta, e.g., from placental perfusate, and umbilical cord blood.
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公开(公告)号：EP4069258A1
公开(公告)日：2022-10-12
申请号：EP20829756.4
申请日：2020-12-04
发明人： KARASIEWICZ-MENDEZ, Kathy , HE, Shuyang , TESS, Kristina , LING, Weifang , JHUN, Kevin , ZELDIS, Jerome, B. , HARIRI, Robert J. , ZHANG, Xiaokui , MA, Qiangzhong , GUO, Wenzhong , ZHANG, Yanliang , JI, Henry Hongjun
IPC分类号： A61K35/17 , C07K14/725 , C12N5/073 , C12N5/0783 , C12N15/867
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