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公开(公告)号：EP3050880B1
公开(公告)日：2019-06-19
申请号：EP14849754.8
申请日：2014-09-28
申请人： Chia Tai Tianqing Pharmaceutical Group Co.,Ltd , Centaurus BioPharma Co., Ltd. , Lianyungang Runzhong Pharmaceutical Co., Ltd.
发明人： XIAO, Dengming , ZHU, Yan , HU, Yuandong , WANG, Huting , LI, Jijun , PENG, Yong , ZHANG, Hui , LUO, Hong , KONG, Fansheng , HAN, Yongxin
IPC分类号： C07D401/12 , C07D401/14 , C07D403/12 , C07D405/14 , A61K31/517 , A61K31/5377 , A61P35/00
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公开(公告)号：EP2780341B1
公开(公告)日：2019-02-13
申请号：EP12849393.9
申请日：2012-11-14
发明人： XIAO, Dengming , LI, Jijun , ZHU, Yan , HU, Yuandong , WANG, Huting , WANG, Zhe , WANG, Zanping , WEI, Yongheng , SUN, Yinghui , WU, Qiong , ZHANG, Hui , PENG, Yong , KONG, Fansheng , SUN, Ying , LUO, Hong , HAN, Yongxin
IPC分类号： C07D473/00 , C07D487/04 , A61K31/52 , A61P35/00 , A61K31/519 , A61P25/00 , A61P29/00 , A61P37/00
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公开(公告)号：EP3412669A1
公开(公告)日：2018-12-12
申请号：EP17747001.0
申请日：2017-02-04
申请人： Chia Tai Tianqing Pharmaceutical Group Co.,Ltd , Centaurus BioPharma Co., Ltd. , Lianyungang Runzhong Pharmaceutical Co., Ltd.
发明人： LI, Jijun , WU, Wei , ZHU, Yan , WANG, Huting , ZHAO, Lijia , HE, Weinan , SUN, Yinghui , PENG, Yong , HAN, Yongxin
IPC分类号： C07D471/14 , C07D471/04 , A61K31/4375 , A61K31/437 , A61P35/00 , A61P31/12 , A61P25/28 , A61P29/00 , A61P9/10
CPC分类号： A61K31/437 , A61K31/4375 , C07D471/04 , C07D471/14
摘要： The present applicationpresent application relates to a compound represented by Formula (III) or a pharmaceutically acceptable salt, solvent compound, active metabolite, crystal polymorph, ester, isomer, or prodrug thereof. The application further provides a pharmaceutical composition comprising the compound represented by Formula (III) and a use thereof for preparing a bromodomain inhibitor for preventing or treating various diseases, such as inflammation and cancer, related to the bromodomain.
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4.发明公开KINASE MODULATING COMPOUNDS, COMPOSITIONS CONTAINING THE SAME AND USE THEREOF 审中-公开KINASEMODULIERENDE化合物，组合物和正确使用
公开(公告)号：EP2780341A1
公开(公告)日：2014-09-24
申请号：EP12849393.9
申请日：2012-11-14
发明人： XIAO, Dengming , LI, Jijun , ZHU, Yan , HU, Yuandong , WANG, Huting , WANG, Zhe , WANG, Zanping , WEI, Yongheng , SUN, Yinghui , WU, Qiong , ZHANG, Hui , PENG, Yong , KONG, Fansheng , SUN, Ying , LUO, Hong , HAN, Yongxin
IPC分类号： C07D473/00 , C07D401/04 , A61K31/52 , A61P35/00
CPC分类号： C07D473/00 , C07D487/04
摘要： The invention provides a compound represented by formula (I) which may modulate a kinase, and a pharmaceutical composition thereof, as well as the method for preventing or treating a protein kinase mediated disease or condition.
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公开(公告)号：EP2670746A1
公开(公告)日：2013-12-11
申请号：EP12742266.5
申请日：2012-01-31
发明人： XIAO, Dengming , ZHU, Yan , HU, Yuandong , WANG, Huting , LIU, Yuliang , LI, Jijun , SUN, Deguang , WANG, Zhe , WEI, Yongheng , WANG, Zanping , TANG, Guojing , JING, Lutao
IPC分类号： C07D401/12 , C07D401/14 , C07D451/14 , A61K31/4523 , A61P43/00 , A61P3/10 , A61P3/06 , A61P3/04 , A61P3/00
CPC分类号： C07D401/04 , C07D401/12 , C07D401/14 , C07D413/14 , C07D451/14 , C07D471/04
摘要： The present invention provides a new class of bicyclic heteroaryl compounds represented by Formula (I), pharmaceutical compositions containing these compounds, and their use for modulating the activity of GPR119 in the treatment of metabolic disorders and complications thereof, as well as methods for the treatment of the metabolic disorders and complications thereof.
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6.发明公开QUINAZOLINE DERIVATIVE AND PREPARATION METHOD THEREFOR 审中-公开CHINAZOLINDERIVAT UND HERSTELLUNGSVERFAHRENDAFÜR
公开(公告)号：EP3050880A1
公开(公告)日：2016-08-03
申请号：EP14849754.8
申请日：2014-09-28
申请人： Chia Tai Tianqing Pharmaceutical Group Co.,Ltd , Centaurus BioPharma Co., Ltd. , Lianyungang Runzhong Pharmaceutical Co., Ltd.
发明人： XIAO, Dengming , ZHU, Yan , HU, Yuandong , WANG, Huting , LI, Jijun , PENG, Yong , ZHANG, Hui , LUO, Hong , KONG, Fansheng , HAN, Yongxin
IPC分类号： C07D403/12 , C07D401/12 , C07D405/14 , C07D401/14 , A61K31/517 , A61K31/5377 , A61P35/00
CPC分类号： C07D403/12 , A61P35/00 , C07D401/12 , C07D401/14 , C07D405/14
摘要： The present invention relates to a quinazoline derivative shown in formula (I) and a preparation method therefor, a pharmaceutical composition comprising the compound shown in formula (I), and an application of the compound in preparing drugs for curing and preventing tumors. The compound of the present invention can irreversibly prevent EGFR phosphorylation, and effectively depress signal transduction of cancer cells, and accordingly has higher anti-tumor activity in vitro and in vivo.
摘要翻译： 本发明涉及式（I）所示的喹唑啉衍生物及其制备方法，包含式（I）所示化合物的药物组合物和该化合物在制备用于治疗和预防肿瘤的药物中的应用。 本发明的化合物可以不可逆地防止EGFR磷酸化，并有效抑制癌细胞的信号转导，因此在体外和体内具有较高的抗肿瘤活性。
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