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公开(公告)号：EP4252772A2
公开(公告)日：2023-10-04
申请号：EP23173235.5
申请日：2012-07-06
申请人： Centre National de la Recherche Scientifique (CNRS) , Azienda socio-sanitaria territoriale Papa Giovanni XXIII , Kadouche, Jean , University of Lausanne
发明人： KADOUCHE, Jean , MACH, Jean-Pierre , MICHIELIN, Olivier , ZOETE, Vincent , IWASZKIEWICZ, Justyna , CERUTTI, Martine , CHOBLET THERY, Sylvie , GOLAY, Josée
IPC分类号： A61K39/395
摘要： The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy chain/light chain mispairing.
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公开(公告)号：EP3872095A1
公开(公告)日：2021-09-01
申请号：EP20168633.4
申请日：2012-07-06
申请人： Centre National de la Recherche Scientifique (CNRS) , University of Lausanne , Azienda socio-sanitaria territoriale Papa Giovanni XXIII , Kadouche, Jean
发明人： KADOUCHE, Jean , MACH, Jean-Pierre , MICHIELIN, Olivier , ZOETE, Vincent , IWASZKIEWICZ, Justyna , CERUTTI, Martine , CHOBLET, Sylvie , GOLAY, Josée
IPC分类号： C07K16/46 , A61K39/395
摘要： The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy chain/light chain mispairing.
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公开(公告)号：EP4252772A3
公开(公告)日：2023-11-01
申请号：EP23173235.5
申请日：2012-07-06
申请人： Centre National de la Recherche Scientifique (CNRS) , Azienda socio-sanitaria territoriale Papa Giovanni XXIII , Kadouche, Jean , University of Lausanne
发明人： KADOUCHE, Jean , MACH, Jean-Pierre , MICHIELIN, Olivier , ZOETE, Vincent , IWASZKIEWICZ, Justyna , CERUTTI, Martine , CHOBLET THERY, Sylvie , GOLAY, Josée
IPC分类号： C07K16/46 , A61K39/395
摘要： The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy chain/light chain mispairing.
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公开(公告)号：EP0938571B1
公开(公告)日：2008-05-07
申请号：EP97948802.0
申请日：1997-10-24
申请人： Novartis AG , University of Lausanne , Swiss Institute for Allergy and Asthma Research , INSTITUT SUISSE DE RECHERCHES EXPERIMENTALES SUR LE CANCER ISREC , Novartis Pharma GmbH
CPC分类号： C07K14/78 , C07K19/00 , C07K2319/00 , C07K2319/21 , C07K2319/73 , C12N15/62
摘要： The present invention concerns an oligomer comprising more than 2 units, wherein each unit comprises a peptidic domain capable of oligomerizing and a domain capable of binding to an acceptor (ligand), wherein the oligomerizing domain is not an antibody or a functional antibody fragment from the constant region. Also described is the use and synthesis of this oligomer.
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公开(公告)号：EP0938571B8
公开(公告)日：2008-07-02
申请号：EP97948802.0
申请日：1997-10-24
申请人： University of Lausanne , Swiss Institute for Allergy and Asthma Research , INSTITUT SUISSE DE RECHERCHES EXPERIMENTALES SUR LE CANCER ISREC , Novartis Pharma GmbH
CPC分类号： C07K14/78 , C07K19/00 , C07K2319/00 , C07K2319/21 , C07K2319/73 , C12N15/62
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公开(公告)号：EP0938571A1
公开(公告)日：1999-09-01
申请号：EP97948802.0
申请日：1997-10-24
申请人： Novartis AG , University of Lausanne , Swiss Institute for Allergy and Asthma Research , INSTITUT SUISSE DE RECHERCHES EXPERIMENTALES SUR LE CANCER ISREC
CPC分类号： C07K14/78 , C07K19/00 , C07K2319/00 , C07K2319/21 , C07K2319/73 , C12N15/62
摘要： The present invention concerns an oligomer comprising more than 2 units, wherein each unit comprises a peptidic domain capable of oligomerizing and a domain capable of binding to an acceptor (ligand), wherein the oligomerizing domain is not an antibody or a functional antibody fragment from the constant region. Also described is the use and synthesis of this oligomer.
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