公开(公告)号：EP1216232A1

公开(公告)日：2002-06-26

申请号：EP00959489.6

申请日：2000-08-25

申请人： Chemocentryx, Inc.

发明人： SCHALL, Thomas, J. ,  DAIRAGHI, Daniel, J. ,  MCMASTER, Brian, E.

IPC分类号： C07D239/91 ,  A61P19/00 ,  A61K31/517

CPC分类号： C07D239/91

摘要： Compounds and compositions are provided that bind to the CXCR3 chemokine receptor and which are useful for treating diseases associated with CXCR3 activity, such as multiple sclerosis.

公开(公告)号：EP1429771B1

公开(公告)日：2009-08-12

申请号：EP02757560.4

申请日：2002-08-29

申请人： ChemoCentryx, Inc.

发明人： MCMASTER, Brian, E. ,  SCHALL, Thomas, J. ,  PENFOLD, Mark ,  WRIGHT, J., J. ,  DAIRAGHI, Daniel, J.

IPC分类号： A61K31/47 ,  A61K31/445 ,  A61K31/44 ,  A61P35/00 ,  A61P25/28

CPC分类号： C07D207/08 ,  A61K31/075 ,  A61K31/135 ,  A61K31/4709 ,  C07D207/27 ,  C07D211/14 ,  C07D211/26 ,  C07D231/12 ,  C07D241/04 ,  C07D295/088 ,  C07D295/096 ,  C07D295/135 ,  C07D295/155 ,  C07D453/04

摘要： Methods for treating CMV or a CMV-related disease are provided that use compounds having the formula (I) wherein Ar is a substituted or unsubstituted 5-14 membered heteroaryl group having from 1 to 5 heteroatoms as ring members; R1 is selected from the group consisting of substituted or unsubstituted aryl(C¿1?-C4)alkyl, heteroaryl(C1-C4)alkyl, -C(O)R?11¿, and -C(O)NR11R12, wherein each R?11 and R12¿ independently is substituted or unsubstituted aryl, substituted or unsubstituted aryl(C¿1?-C4)alkyl, substituted or unsubstituted (C4-C8)cycloalkyl(C1-C4)alkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroaryl(C1-C4)alkyl and substituted or unsubstituted hetero(C4-C8)cycloalkyl(C1-C4)alkyl; R?2¿ is H or (C¿1?-C8)alkyl; and Z?N¿ is a substituted or unsubstituted hetero(C¿6?-C10)bicycloalkyl group.

公开(公告)号：EP1429771A2

公开(公告)日：2004-06-23

申请号：EP02757560.4

申请日：2002-08-29

申请人： Chemocentryx, Inc.

发明人： MCMASTER, Brian, E. ,  SCHALL, Thomas, J. ,  PENFOLD, Mark ,  WRIGHT, J., J. ,  DAIRAGHI, Daniel, J.

IPC分类号： A61K31/47 ,  A61K31/445 ,  A61K31/44

CPC分类号： C07D207/08 ,  A61K31/075 ,  A61K31/135 ,  A61K31/4709 ,  C07D207/27 ,  C07D211/14 ,  C07D211/26 ,  C07D231/12 ,  C07D241/04 ,  C07D295/088 ,  C07D295/096 ,  C07D295/135 ,  C07D295/155 ,  C07D453/04

摘要： Methods for treating CMV or a CMV-related disease are provided that use compounds having the formula (I) wherein Ar is a substituted or unsubstituted 5-14 membered heteroaryl group having from 1 to 5 heteroatoms as ring members; R1 is selected from the group consisting of substituted or unsubstituted aryl(C¿1?-C4)alkyl, heteroaryl(C1-C4)alkyl, -C(O)R?11¿, and -C(O)NR11R12, wherein each R?11 and R12¿ independently is substituted or unsubstituted aryl, substituted or unsubstituted aryl(C¿1?-C4)alkyl, substituted or unsubstituted (C4-C8)cycloalkyl(C1-C4)alkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroaryl(C1-C4)alkyl and substituted or unsubstituted hetero(C4-C8)cycloalkyl(C1-C4)alkyl; R?2¿ is H or (C¿1?-C8)alkyl; and Z?N¿ is a substituted or unsubstituted hetero(C¿6?-C10)bicycloalkyl group.

公开(公告)号：EP1224222A2

公开(公告)日：2002-07-24

申请号：EP00973455.9

申请日：2000-10-10

申请人： Chemocentryx, Inc.

发明人： GOSLING, Jennifa ,  DAIRAGHI, Daniel, J. ,  HANLEY, Michael ,  MIAO, Zhenhua ,  TALBOT, Dale ,  SCHALL, Thomas, J.

IPC分类号： C07K14/705

CPC分类号： C07K14/7158 ,  C07K14/521 ,  C07K2319/00 ,  G01N33/5088 ,  G01N33/531 ,  G01N33/6863 ,  G01N2500/00

摘要： The invention provides polypeptides and polynucleotides encoding a novel chemokine receptor, CCX CKR. The invention further provides reagents and methods for identifying agents that modulate the activity or expression of the receptors, as well as methods for detecting receptor expression.

公开(公告)号：EP1224222B1

公开(公告)日：2010-02-10

申请号：EP00973455.9

申请日：2000-10-10

申请人： ChemoCentryx, Inc.

发明人： GOSLING, Jennifa ,  DAIRAGHI, Daniel, J. ,  HANLEY, Michael ,  MIAO, Zhenhua ,  SCHALL, Thomas, J.

IPC分类号： C07K14/705

CPC分类号： C07K14/7158 ,  C07K14/521 ,  C07K2319/00 ,  G01N33/5088 ,  G01N33/531 ,  G01N33/6863 ,  G01N2500/00

公开(公告)号：EP1578341A2

公开(公告)日：2005-09-28

申请号：EP01981850.9

申请日：2001-10-11

申请人： Tularik Inc. ,  Chemocentryx, Inc.

发明人： COLLINS, Tassie ,  DAIRAGHI, Daniel, J. ,  MAHMUD, Hoosen ,  MCMASTER, Brian, E. ,  MEDINA, Julio, C. ,  SCHALL, Thomas, J. ,  XU, Feng ,  WANG, Xuemei

IPC分类号： A61K6/00 ,  C07D277/42 ,  C07D277/82 ,  C07D417/12 ,  C07D513/04 ,  A61K31/426 ,  A61P11/00 ,  A61P33/00

CPC分类号： C07D417/12 ,  A61K31/00 ,  A61K31/265 ,  A61K31/341 ,  A61K31/351 ,  A61K31/357 ,  A61K31/36 ,  A61K31/381 ,  A61K31/4245 ,  A61K31/426 ,  C07D277/42 ,  C07D277/82 ,  C07D513/04

摘要： Compounds and compositions are provided that bind to the CCR4 chemokine receptor and which are useful for treating diseases associated with CCR4 activity, such as contact hypersensitivity.

公开(公告)号：EP1216232B1

公开(公告)日：2006-10-11

申请号：EP00959489.6

申请日：2000-08-25

申请人： ChemoCentryx, Inc.

发明人： SCHALL, Thomas, J. ,  DAIRAGHI, Daniel, J. ,  MCMASTER, Brian, E.

IPC分类号： C07D239/91 ,  A61P19/00 ,  A61K31/517

CPC分类号： C07D239/91

摘要： Compounds and compositions are provided that bind to the CXCR3 chemokine receptor and which are useful for treating diseases associated with CXCR3 activity, such as multiple sclerosis.

公开(公告)号：EP1465488A1

公开(公告)日：2004-10-13

申请号：EP02757525.7

申请日：2002-08-29

申请人： Chemocentryx, Inc.

发明人： MCMASTER, Brian, E. ,  SCHALL, Thomas, J. ,  PENFOLD, Mark ,  WRIGHT, J., J. ,  DAIRAGHI, Daniel, J.

IPC分类号： A01N33/02 ,  A01N33/18 ,  A01N33/24 ,  A01N31/14 ,  A61K31/135 ,  A61K31/075

CPC分类号： C07D207/08 ,  A61K31/075 ,  A61K31/135 ,  A61K31/4709 ,  C07D207/27 ,  C07D211/14 ,  C07D211/26 ,  C07D231/12 ,  C07D241/04 ,  C07D295/088 ,  C07D295/096 ,  C07D295/135 ,  C07D295/155 ,  C07D453/04

摘要： Methods for treating CMV and CMV-related diseases are provided that use compounds having formula (II) wherein the subscripts m and n are each independently integers from 1 to 2; and the R groups are as defined in the specification.