公开(公告)号：EP1562940B1

公开(公告)日：2007-05-30

申请号：EP03796416.0

申请日：2003-11-17

申请人： ChemoCentryx, Inc.

发明人： UNGASHE, Solomon ,  WEI, Zheng ,  WRIGHT, J., J. ,  PENNELL, Andrew, M.K.

IPC分类号： C07D213/89 ,  A61K31/44 ,  A61P29/00

CPC分类号： C07C311/29 ,  C07C311/21 ,  C07C311/46 ,  C07C317/14 ,  C07D213/26 ,  C07D213/50 ,  C07D213/70 ,  C07D213/74 ,  C07D213/84 ,  C07D213/89 ,  C07D241/12 ,  C07D413/12

摘要： Compounds of formula (I) (in which the variables L, X, Y and Z are as defined in the claims) are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulphonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.

公开(公告)号：EP1567486B1

公开(公告)日：2008-01-16

申请号：EP03816012.3

申请日：2003-11-18

申请人： ChemoCentryx, Inc.

发明人： UNGASHE, Solomon ,  WEI, Zheng ,  WRIGHT, J., J. ,  PENNELL, Andrew ,  PREMACK, Brett ,  SCHALL, Thomas, J.

IPC分类号： C07C311/21 ,  A61K31/18 ,  A61P29/00

CPC分类号： C07C311/29 ,  C07C311/21 ,  C07C311/46 ,  C07C317/14 ,  C07D213/26 ,  C07D213/50 ,  C07D213/70 ,  C07D213/74 ,  C07D213/84 ,  C07D213/89 ,  C07D241/12 ,  C07D413/12

摘要： Compounds are provided that act as potent antagonists of chemokine receptors. The compounds are generally aryl sulfonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of chemokine receptor-mediated diseases, and as controls in assays for the identification of chemokine antagonists.

公开(公告)号：EP1429771B1

公开(公告)日：2009-08-12

申请号：EP02757560.4

申请日：2002-08-29

申请人： ChemoCentryx, Inc.

发明人： MCMASTER, Brian, E. ,  SCHALL, Thomas, J. ,  PENFOLD, Mark ,  WRIGHT, J., J. ,  DAIRAGHI, Daniel, J.

IPC分类号： A61K31/47 ,  A61K31/445 ,  A61K31/44 ,  A61P35/00 ,  A61P25/28

CPC分类号： C07D207/08 ,  A61K31/075 ,  A61K31/135 ,  A61K31/4709 ,  C07D207/27 ,  C07D211/14 ,  C07D211/26 ,  C07D231/12 ,  C07D241/04 ,  C07D295/088 ,  C07D295/096 ,  C07D295/135 ,  C07D295/155 ,  C07D453/04

摘要： Methods for treating CMV or a CMV-related disease are provided that use compounds having the formula (I) wherein Ar is a substituted or unsubstituted 5-14 membered heteroaryl group having from 1 to 5 heteroatoms as ring members; R1 is selected from the group consisting of substituted or unsubstituted aryl(C¿1?-C4)alkyl, heteroaryl(C1-C4)alkyl, -C(O)R?11¿, and -C(O)NR11R12, wherein each R?11 and R12¿ independently is substituted or unsubstituted aryl, substituted or unsubstituted aryl(C¿1?-C4)alkyl, substituted or unsubstituted (C4-C8)cycloalkyl(C1-C4)alkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroaryl(C1-C4)alkyl and substituted or unsubstituted hetero(C4-C8)cycloalkyl(C1-C4)alkyl; R?2¿ is H or (C¿1?-C8)alkyl; and Z?N¿ is a substituted or unsubstituted hetero(C¿6?-C10)bicycloalkyl group.

公开(公告)号：EP1429771A2

公开(公告)日：2004-06-23

申请号：EP02757560.4

申请日：2002-08-29

申请人： Chemocentryx, Inc.

发明人： MCMASTER, Brian, E. ,  SCHALL, Thomas, J. ,  PENFOLD, Mark ,  WRIGHT, J., J. ,  DAIRAGHI, Daniel, J.

IPC分类号： A61K31/47 ,  A61K31/445 ,  A61K31/44

CPC分类号： C07D207/08 ,  A61K31/075 ,  A61K31/135 ,  A61K31/4709 ,  C07D207/27 ,  C07D211/14 ,  C07D211/26 ,  C07D231/12 ,  C07D241/04 ,  C07D295/088 ,  C07D295/096 ,  C07D295/135 ,  C07D295/155 ,  C07D453/04

摘要： Methods for treating CMV or a CMV-related disease are provided that use compounds having the formula (I) wherein Ar is a substituted or unsubstituted 5-14 membered heteroaryl group having from 1 to 5 heteroatoms as ring members; R1 is selected from the group consisting of substituted or unsubstituted aryl(C¿1?-C4)alkyl, heteroaryl(C1-C4)alkyl, -C(O)R?11¿, and -C(O)NR11R12, wherein each R?11 and R12¿ independently is substituted or unsubstituted aryl, substituted or unsubstituted aryl(C¿1?-C4)alkyl, substituted or unsubstituted (C4-C8)cycloalkyl(C1-C4)alkyl, substituted or unsubstituted heteroaryl, substituted or unsubstituted heteroaryl(C1-C4)alkyl and substituted or unsubstituted hetero(C4-C8)cycloalkyl(C1-C4)alkyl; R?2¿ is H or (C¿1?-C8)alkyl; and Z?N¿ is a substituted or unsubstituted hetero(C¿6?-C10)bicycloalkyl group.

公开(公告)号：EP1562940A2

公开(公告)日：2005-08-17

申请号：EP03796416.0

申请日：2003-11-17

申请人： ChemoCentryx Inc

发明人： UNGASHE, Solomon ,  WEI, Zheng ,  WRIGHT, J., J. ,  PENNELL, Andrew

IPC分类号： C07D413/12 ,  C07D213/50 ,  C07D213/89 ,  C07D213/74 ,  C07D213/70 ,  C07D213/26 ,  C07D241/12 ,  C07D213/84 ,  A61K31/44 ,  A61P29/00

CPC分类号： C07C311/29 ,  C07C311/21 ,  C07C311/46 ,  C07C317/14 ,  C07D213/26 ,  C07D213/50 ,  C07D213/70 ,  C07D213/74 ,  C07D213/84 ,  C07D213/89 ,  C07D241/12 ,  C07D413/12

摘要： Compounds of formula (I) (in which the variables L, X, Y and Z are as defined in the claims) are provided that act as potent antagonists of the CCR9 receptor, and which have been further confirmed in animal testing for inflammation, one of the hallmark disease states for CCR9. The compounds are generally aryl sulphonamide derivatives and are useful in pharmaceutical compositions, methods for the treatment of CCR9-mediated diseases, and as controls in assays for the identification of CCR9 antagonists.

公开(公告)号：EP1465488A1

公开(公告)日：2004-10-13

申请号：EP02757525.7

申请日：2002-08-29

申请人： Chemocentryx, Inc.

发明人： MCMASTER, Brian, E. ,  SCHALL, Thomas, J. ,  PENFOLD, Mark ,  WRIGHT, J., J. ,  DAIRAGHI, Daniel, J.

IPC分类号： A01N33/02 ,  A01N33/18 ,  A01N33/24 ,  A01N31/14 ,  A61K31/135 ,  A61K31/075

CPC分类号： C07D207/08 ,  A61K31/075 ,  A61K31/135 ,  A61K31/4709 ,  C07D207/27 ,  C07D211/14 ,  C07D211/26 ,  C07D231/12 ,  C07D241/04 ,  C07D295/088 ,  C07D295/096 ,  C07D295/135 ,  C07D295/155 ,  C07D453/04

摘要： Methods for treating CMV and CMV-related diseases are provided that use compounds having formula (II) wherein the subscripts m and n are each independently integers from 1 to 2; and the R groups are as defined in the specification.