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公开(公告)号：EP2931317A2
公开(公告)日：2015-10-21
申请号：EP13862109.9
申请日：2013-12-12
发明人： CHOE, Hyeryun , JEMIELITY, Stephanie , UMETSU, Dale, T. , DE KRUYFF, Rosemarie, Helena , FREEMAN, Gordon
IPC分类号： A61K48/00 , A61K39/395 , A61P31/12 , A61P31/00
CPC分类号： A61K38/1774 , A61K31/685 , A61K31/7105 , A61K31/713 , A61K45/00 , C07K14/70503 , C07K16/2803 , C07K2317/76 , C07K2319/30 , C12N15/113 , C12N15/1138 , C12N2310/11 , C12N2310/14 , C12N2310/17 , C12N2310/531
摘要： The invention provides methods, compositions, and kits featuring agents that inhibit viral entry mediated by T-cell Immunoglobulin and Mucin-domain containing proteins (TIM proteins) and other phosphatidylserine receptors.
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公开(公告)号：EP2079760B1
公开(公告)日：2016-04-27
申请号：EP07866029.7
申请日：2007-12-26
申请人： Emory University , Dana-Farber Cancer Institute, Inc. , President and Fellows of Harvard College
发明人： AHMED, Rafi , AMARA, Rama , FREEMAN, Gordon , SHARPE, Arlene
CPC分类号： C07K16/2827 , A61K39/12 , A61K39/395 , A61K2039/505 , A61K2039/507 , A61K2039/5158 , A61K2039/5256 , C07K16/2818 , C12N2710/24143 , C12N2740/16011 , C12N2760/10011 , C12N2760/10034 , C12N2770/24211 , A61K2300/00
摘要： PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD-1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subj ects with infections, such as persistent infections can be treated using PD-1 antagonists. In additions, subjects with tumors can be treated using the PD-1 antagonists. In several examples, subjects can be treated by transplanting a therapeutically effective amount of activated T cells that recognize an antigen of interest and by administering a therapeutically effective amount of a PD-1 antagonist.
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公开(公告)号：EP1320599A2
公开(公告)日：2003-06-25
申请号：EP01952332.3
申请日：2001-06-28
发明人： FREEMAN, Gordon , CHERNOVA, Irene , CHERNOVA, Tatyana , MALENKOVICH, Nelly , WOOD, Clive , LATCHMAN, Yvette , SHARPE, Arlene, H.
IPC分类号： C12N15/12 , C07K14/705 , G01N33/50
CPC分类号： G01N33/6854 , G01N33/5014 , G01N33/505 , G01N33/5052 , G01N33/573 , G01N2800/52
摘要： The invention provides isolated nucleic acid molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PD-L2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PD-L2 gene has been introduced or disrupted. The invention further provides isolated PD-L2 polypeptides, fusion proteins, antigenic peptides and anti-PD-L2 antibodies. The invention still further provides methods for promoting or inhibiting the interaction between PD-L2 and PD-1. Diagnostic and treatment methods utilizing compositions of the invention are also provided.
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4.发明授权METHODS FOR DETERMINING THE EFFICACY OF PD-1 ANTAGONISTS 有权VERFAHREN ZUR BESTIMMUNG DER WIRKSAMKEIT VON PD-1 ANTAGONISTEN
公开(公告)号：EP2370593B1
公开(公告)日：2016-03-30
申请号：EP09829832.6
申请日：2009-11-27
IPC分类号： A61K39/39 , A61K39/00 , G01N33/569 , G01N33/50 , C07K16/28 , A61K39/395
CPC分类号： G01N33/5052 , A61K31/7105 , A61K39/0011 , A61K39/12 , A61K39/39 , A61K39/39541 , A61K2039/505 , A61K2039/507 , A61K2039/55516 , C07K16/2803 , C07K16/2818 , C07K16/2827 , C07K2317/24 , C07K2317/74 , C07K2317/76 , C12N15/1138 , C12N2310/14 , C12N2760/10034 , G01N33/5088 , G01N33/56966 , G01N2333/52 , G01N2800/26 , Y02A50/41 , A61K2300/00
摘要： PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD-1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subjects with infections, such as persistent infections can be treated using PD-1 antagonists. In addition, subjects with tumors can be treated using the PD-1 antagonists. In several examples, subjects can be treated by transplanting a therapeutically effective amount of activated T cells that recognize an antigen of interest and by administering a therapeutically effective amount of a PD-1 antagonist. Methods are also disclosed for determining the efficacy of a PD-1 antagonist in a subject administered the PD-1 antagonist. In some embodiments, these methods include measuring proliferation of memory B cells in a sample from a subject administered the PD-1 antagonist.
摘要翻译： 公开了可用于降低受试者中PD-1的表达或活性的PD-1拮抗剂。 使用这些PD-1拮抗剂与来自感染剂或肿瘤的抗原可以增强对感染剂或肿瘤细胞特异性的免疫应答。 因此，可以使用PD-1拮抗剂治疗感染的受试者，例如持续感染。 此外，可以使用PD-1拮抗剂治疗具有肿瘤的受试者。 在几个实例中，可以通过移植治疗有效量的识别感兴趣的抗原的活化T细胞并通过施用治疗有效量的PD-1拮抗剂来治疗受试者。 还公开了用于测定施用PD-1拮抗剂的受试者中PD-1拮抗剂的功效的方法。 在一些实施方案中，这些方法包括测量来自施用PD-1拮抗剂的受试者的样品中记忆B细胞的增殖。
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公开(公告)号：EP1210424A1
公开(公告)日：2002-06-05
申请号：EP00955878.4
申请日：2000-08-23
IPC分类号： C12N15/12 , C07K14/705 , C12N5/10 , A61K38/17 , A61K39/395 , G01N33/50 , C07K16/28
CPC分类号： A61K45/06 , A61K39/00 , A61K2039/55516 , C07K14/70503 , C07K14/70532 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/622 , C07K2319/30
摘要： The invention provides isolated nucleic acids molecules, designated B7-4 nucleic acid molecules, which encode novel B7-4 polypeptides. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing B7-4 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a B7-4 gene has been introduced or disrupted. The invention still further provides isolated B7-4 proteins, fusion proteins, antigenic peptides and anti-B7-4 antibodies. Diagnostic, screening, and therapeutic methods utilizing compositions of the invention are also provided.
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公开(公告)号：EP1297135B1
公开(公告)日：2013-01-09
申请号：EP01950768.0
申请日：2001-06-28
IPC分类号： C07K16/18 , C07K16/28 , A61K39/395
CPC分类号： G01N33/6854 , G01N33/5014 , G01N33/505 , G01N33/5052 , G01N33/573 , G01N2800/52
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公开(公告)号：EP1297135A2
公开(公告)日：2003-04-02
申请号：EP01950768.0
申请日：2001-06-28
CPC分类号： G01N33/6854 , G01N33/5014 , G01N33/505 , G01N33/5052 , G01N33/573 , G01N2800/52
摘要： The invention provides isolated nucleic acids molecules, designated PD-L2 nucleic acid molecules, which encode novel B7-related molecules which are ligands for PD-1. The invention also provides antisense nucleic acid molecules, recombinant expression vectors containing PD-L2 nucleic acid molecules, host cells into which the expression vectors have been introduced, and nonhuman transgenic animals in which a PD-L2 gene has been introduced or disrupted. The invention further provides isolated PD-L2 polypeptides, fusion proteins, antigenic peptides and anti-PD-L2 antibodies. The invention still further provides methods for promoting or inhibiting the interaction between PD-L2 and PD-1. Diagnostic and treatment methods utilizing compositions of the invention are also provided.
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公开(公告)号：EP2376105B1
公开(公告)日：2015-07-29
申请号：EP09837720.3
申请日：2009-12-18
IPC分类号： A61K45/06 , A61K38/17 , A61K39/395 , A61P35/00 , C07K14/705
CPC分类号： C07K14/70596 , A61K38/177 , A61K45/06 , C07K14/7056 , C07K2319/30
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公开(公告)号：EP2376105A1
公开(公告)日：2011-10-19
申请号：EP09837720.3
申请日：2009-12-18
CPC分类号： C07K14/70596 , A61K38/177 , A61K45/06 , C07K14/7056 , C07K2319/30
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公开(公告)号：EP1210424B1
公开(公告)日：2007-02-07
申请号：EP00955878.4
申请日：2000-08-23
IPC分类号： C12N15/12 , C07K14/705 , C12N5/10 , A61K38/17 , A61K39/395 , G01N33/50 , C07K16/28
CPC分类号： A61K45/06 , A61K39/00 , A61K2039/55516 , C07K14/70503 , C07K14/70532 , C07K16/2803 , C07K16/2827 , C07K2317/21 , C07K2317/24 , C07K2317/622 , C07K2319/30
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