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公开(公告)号：EP3323440A1
公开(公告)日：2018-05-23
申请号：EP16836634.2
申请日：2016-08-15
发明人： YE, Lei
CPC分类号： A61L27/56 , A61L27/02 , A61L27/025 , A61L27/04 , A61L27/047 , A61L27/18 , A61L27/20 , A61L2430/02 , B01D39/2027 , B01D2239/10 , B22F3/11 , B22F2301/20 , C01B32/956 , C01P2006/16 , C22C1/05 , C22C1/08
摘要： The present invention discloses a porous material and preparation method thereof. The material includes a material body. The body is composed of pore cavities classified into different levels according to the pore size of the material and cavity walls surrounding to form the pore cavities. The lower-level pore cavities are arranged on the cavity walls of the upper-level pore cavities formed by surrounding a three-dimensional space. All the pore cavities are interconnected. The preparation method is: mixing the raw powders with a pore-forming agent for the smallest-level pore cavities of the porous material to formulate a slurry , uniformly filling the slurry into the polymer material support to form a green body and get dried and smashed to obtain mixed grains, uniformly mixing the mixed grains with the pore-forming agent for upper-level pore cavities which are greater than the smallest-level pore cavities of the porous material to make a compact green body, and then performing vacuum sintering. Perform the conventional follow-up treatment in accordance with the raw materials process of the porous material. The porous material has good connectivity and uniform properties. Each level of the porous material has its own physicochemical properties and can fully satisfy the demands of various functions. The porous material can be used as a biomaterial, a separation material and the like, and the preparation method is simple and easy to implement.
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公开(公告)号：EP2623048B1
公开(公告)日：2015-09-30
申请号：EP11828040.3
申请日：2011-08-26
发明人： YE, Lei , ZHOU, Jian , FENG, Hua , LI, Fei , ZHU, Hengyang , LI, Congxiao
CPC分类号： A61B17/162 , A61B17/1615 , A61B17/1695 , B23B31/005 , B23B31/1071 , Y10T279/17
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公开(公告)号：EP2623046B1
公开(公告)日：2015-08-05
申请号：EP11828028.8
申请日：2011-08-24
发明人： YE, Lei , ZHOU, Jian , FENG, Hua , LI, Fei , ZHU, Hengyang , LI, Congxiao
IPC分类号： A61B17/16
CPC分类号： A61B17/162 , A61B17/1695 , B23B31/10 , B23B31/1071 , Y10S279/905 , Y10T279/17 , Y10T279/17145 , Y10T279/17196 , Y10T279/17743 , Y10T279/17752
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公开(公告)号：EP3326662A1
公开(公告)日：2018-05-30
申请号：EP16848016.8
申请日：2016-09-08
发明人： YE, Lei
CPC分类号： A61F2/28 , A61F2/30771 , A61F2002/2821 , A61F2002/30668 , A61F2002/30784 , A61F2002/3092 , A61F2002/3093 , A61F2310/00131 , A61F2310/00215 , A61F2310/00281 , A61L27/04 , A61L27/08 , A61L27/56
摘要： The present invention relates to a new application of a porous material. The porous material is composed of pore cavities and cavity walls surrounding the pore cavities, wherein the pore cavities of the porous material are three-dimensionally interconnected; the capillary force of the porous material is 5 Pa or more; and a contact angle between a surface of the cavity wall of the porous material and a liquid phase material circulating therein is less than 90°. The porous material is applied as a microcirculation power source. The porous material is used in a circulation system as a microcirculation power source for providing material exchange. The porous material is used in a separation system as a microcirculation power source for providing material separation and movement. The porous material is used in a medical implant system as a microcirculation power source for providing tissue cell growth.
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公开(公告)号：EP3299016A1
公开(公告)日：2018-03-28
申请号：EP16795868.5
申请日：2016-05-17
发明人： YE, Lei
IPC分类号： A61K31/365 , A61P25/18
CPC分类号： A61K31/4015 , A61K31/365 , A61P25/08
摘要： Provided is a use of dextrorotatory oxiracetam in the preparation of a drug for preventing or treating epilepsy. An experimental result shows that the dextrorotatory oxiracetam has an obvious effect in the treatment of generalized epilepsy seizure, partial epilepsy seizure and status epilepticus.
摘要翻译： 提供了右旋奥拉西坦在制备用于预防或治疗癫痫的药物中的用途。 实验结果表明，右旋奥拉西坦治疗广泛性癫痫发作，部分性癫痫发作和癫痫持续状态有明显疗效。
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6.发明授权CRYSTAL FORM II OF (S)-4-HYDROXY-2-OXO-1-PYRROLIDINE ACETAMIDE AND PREPARATION METHOD THEREOF 有权（S）-4-羟基-2-氧代-1-吡咯烷乙酰胺和方法的晶形II THEREOF
公开(公告)号：EP2743260B1
公开(公告)日：2016-10-19
申请号：EP12822639.6
申请日：2012-04-24
发明人： YE, Lei
IPC分类号： C07D207/273
CPC分类号： C07D207/273
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公开(公告)号：EP3339425A1
公开(公告)日：2018-06-27
申请号：EP16836578.1
申请日：2016-08-09
发明人： YE, Lei
IPC分类号： C12M3/00
摘要： The present invention relates to a tissue cell culture device which includes a tissue cell culture body. The porous material used as the tissue cell culture body is a porous metallic material which is formed by pore cavities classified by a pore size of the material and cavity walls surrounding to form the classified pore cavities. The cavity wall surrounding to form an upper level of large pore cavity is provided with a lower level of small pore cavity. The pore cavities in the same level are in communication with each other. The pore cavities in different levels are also in communication with each other. This device is particularly beneficial for cell cultivation and allows tissue cells to grow freely and normally in a three-dimensional space. Especially, with the metallic material, the tissue cell culture body is not prone to damages under vibration. Also, during the cell cultivation, a loading of an insert piece can be simulated, such that a high load lasting for a long time can be withstood.
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公开(公告)号：EP3327156A1
公开(公告)日：2018-05-30
申请号：EP16840729.4
申请日：2016-08-16
发明人： YE, Lei
CPC分类号： C22C1/08 , A61L27/045 , A61L27/06 , B22F1/0014 , B22F3/1103 , B22F3/1121 , B22F3/114 , B22F9/04 , C22C1/0433 , C22C1/045 , C22C14/00 , C22C19/07 , C22C27/02 , C22C27/04 , C22C38/44
摘要： The present invention discloses a porous metal material. The material is multilevel porous metal material, which is classified based on the pore size of the material. The number of classified levels is at least more than two. The pore size of the smallest level of porous metal material is less than 1 micrometer. The elasticity modulus of the smallest level of porous metal material is less than 80GPa. The porosity is no less than 48%. The preparation method thereof is as follows. The raw material powder used to prepare porous metal material and the pore-forming agent used to prepare the smallest level of pores cavities are mixed to prepare the slurry. The slurry is uniformly filled into polymer material support to form a green body. The green body is dried and crushed to obtain mixed grains. Mixed grains are uniformly mixed with the pore-forming agent used to prepare the pore cavity which is larger than the smallest level of pore cavities, so as to prepare the compact green body. The compact green body is sintered in vacuum and is subjected to conventional follow-up processing based on the raw material processing. Such material with multilevel elasticity modulus can meet different usage requirements. The connectivity is good. Such material is particularly suitable to be used as tissue regeneration material. The preparation method is simple and easy to achieve.
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公开(公告)号：EP3323880A1
公开(公告)日：2018-05-23
申请号：EP16836577.3
申请日：2016-08-09
发明人： YE, Lei
IPC分类号： C12M3/02
CPC分类号： C12M3/02 , C12M3/04 , C12M23/08 , C12M23/16 , C12M25/14 , C12M25/18 , C12N5/0062 , C12N5/0068
摘要： The present invention relates to a culture device for tissue cell suspension. The culture device includes a tissue cell culture body. The tissue cell culture body is a porous material. The porous material is formed by cavities classified into different levels according to the pore size of material and cavity walls surrounding to form the cavities. A lower level of small cavities is provided to surround the cavity wall which forms the upper level of large cavity. Cavities of each level are in communication with each other, and cavities between respective levels are also in communication with each other. The culture device further includes a swirler device. Such culture device can particularly facilitate normal and unrestricted growth of the suspension of cells in three-dimensional space, obstructing the formation of over-dense cell region or nutrient-rich region during the cell culturing, enabling a uniform cell distribution, and facilitating normal growth of cells.
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公开(公告)号：EP3323879A1
公开(公告)日：2018-05-23
申请号：EP16836579.9
申请日：2016-08-09
发明人： YE, Lei
IPC分类号： C12M3/00
摘要： The present invention provides a culture device for tissue cell, and the culture device for tissue cell includes a tissue cell culture body. The porous material of the tissue cell culture body is composed by pore cavities which are classified according to the material pore size and cavity walls which are formed around the pore cavity at all levels. And the lower level small pore cavities are provided on the cavity wall formed around the upper level large pore cavities. The pore cavities within the same level are in communication with each other. And the pore cavities at all levels are also be in communication with each other. This device is particularly benefit for cell culture, so that tissue cells can freely and normally grow in three-dimensional space.
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