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公开(公告)号：EP4342529A2
公开(公告)日：2024-03-27
申请号：EP23205683.8
申请日：2016-12-16
发明人： SAMPEI, Zenjiro
IPC分类号： A61P7/00
摘要： The invention provides anti-C5 antibodies and methods of using the same. In some embodiments, an isolated anti-C5 antibody of the present invention binds to an epitope within the beta chain of C5 with a higher affinity at neutral pH than at acidic pH. The invention also provides isolated nucleic acids encoding an anti-C5 antibody of the present invention. The invention also provides host cells comprising a nucleic acid of the present invention. The invention also provides a method of producing an antibody comprising culturing a host cell of the present invention so that the antibody is produced. The invention further provides a method of producing an anti-C5 antibody comprising immunizing an animal against a polypeptide which comprises the MG1-MG2 domain of the beta chain of C5. Anti-C5 antibodies of the present invention may be for use as a medicament.
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公开(公告)号：EP3233921A1
公开(公告)日：2017-10-25
申请号：EP15869565.0
申请日：2015-12-18
发明人： RUIKE, Yoshinao , SAMPEI, Zenjiro
CPC分类号： C07K16/18 , A61K31/519 , C07K2317/21 , C07K2317/24 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/564 , G01N33/6863 , G01N2333/4716
摘要： An objective of the invention is to provide anti-C5 antibodies and methods of using the same. The invention provides anti-C5 antibodies and methods of using the same. In some embodiments, an isolated anti-C5 antibody of the present invention binds to an epitope within the β chain of C5 with a higher affinity at neutral pH than at acidic pH. The invention also provides isolated nucleic acids encoding an anti-C5 antibody of the present invention. The invention also provides host cells comprising a nucleic acid of the present invention. The invention also provides a method of producing an antibody comprising culturing a host cell of the present invention so that the antibody is produced. The invention further provides a method of producing an anti-C5 antibody comprising immunizing an animal against a polypeptide which comprises the MG1-MG2 domain of the β chain of C5. Anti-C5 antibodies of the present invention may be for use as a medicament. Anti-C5 antibodies of the present invention may be for use in treating a complement-mediated disease or condition which involves excessive or uncontrolled activation of C5. Anti-C5 antibodies of the present invention may be for use in enhancing the clearance of C5 from plasma.
摘要翻译： 本发明的目的是提供抗C5抗体及其使用方法。 本发明提供了抗C5抗体及其使用方法。 在一些实施方案中，本发明的分离的抗C5抗体在中性pH下比在酸性pH下以更高的亲和力结合C5的β链内的表位。 本发明还提供了编码本发明的抗C5抗体的分离的核酸。 本发明还提供了包含本发明核酸的宿主细胞。 本发明还提供了生产抗体的方法，包括培养本发明的宿主细胞以产生抗体。 本发明进一步提供了产生抗C5抗体的方法，其包括使动物免疫包含C5的β链的MG1-MG2结构域的多肽。 本发明的抗C5抗体可以用作药物。
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3.发明公开
公开(公告)号：EP3512879A1
公开(公告)日：2019-07-24
申请号：EP17851188.7
申请日：2017-09-15
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公开(公告)号：EP3390442A1
公开(公告)日：2018-10-24
申请号：EP16875755.7
申请日：2016-12-16
发明人： SAMPEI, Zenjiro
CPC分类号： C07K16/18 , A61K2039/505 , C07K2299/00 , C07K2317/24 , C07K2317/30 , C07K2317/33 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C12N5/10
摘要： The invention provides anti-C5 antibodies and methods of using the same. In some embodiments, an isolated anti-C5 antibody of the present invention binds to an epitope within the beta chain of C5 with a higher affinity at neutral pH than at acidic pH. The invention also provides isolated nucleic acids encoding an anti-C5 antibody of the present invention. The invention also provides host cells comprising a nucleic acid of the present invention. The invention also provides a method of producing an antibody comprising culturing a host cell of the present invention so that the antibody is produced. The invention further provides a method of producing an anti-C5 antibody comprising immunizing an animal against a polypeptide which comprises the MG1-MG2 domain of the beta chain of C5. Anti-C5 antibodies of the present invention may be for use as a medicament.
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公开(公告)号：EP4223774A3
公开(公告)日：2023-09-27
申请号：EP23165354.4
申请日：2018-01-31
发明人： SHINOMIYA, Kenji , YONEYAMA, Koichiro , SHIBAHARA, Norihito , TSUBOI, Yoshinori , FUKUZAWA, Taku , HARAYA, Kenta , SAMPEI, Zenjiro , BOGMAN, Katrijn , CHAROIN, Jean Eric
摘要： The present invention relates to pharmaceutical compositions for use in the treatment or prevention of a C5-related disease and methods for treating or preventing a C5-related disease. The present invention further relates to dosages and administrations of anti-C5 antibody or pharmaceutical compositions containing the anti-C5 antibody.
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公开(公告)号：EP2522724B1
公开(公告)日：2020-02-05
申请号：EP10839561.7
申请日：2010-12-24
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7.发明公开MULTI-SPECIFIC ANTIGEN-BINDING MOLECULE HAVING ALTERNATIVE FUNCTION TO FUNCTION OF BLOOD COAGULATION FACTOR VIII 审中-公开具有选择性功能的多特异性抗原结合分子对血液凝固因子VIII的作用
公开(公告)号：EP3318633A1
公开(公告)日：2018-05-09
申请号：EP17200495.4
申请日：2011-11-17
发明人： IGAWA, Tomoyuki , SAMPEI, Zenjiro , KOJIMA, Tetsuo , SOEDA, Tetsuhiro , MUTO, Atsushi , KITAZAWA, Takehisa , NISHIDA, Yukiko , IMAI, Chifumi , SUZUKI, Tsukasa , YOSHIHASHI, Kazutaka
CPC分类号： C07K16/40 , C07K16/36 , C07K2317/31 , C07K2317/51 , C07K2317/56 , C07K2317/565 , C07K2317/75 , C07K2317/76 , C07K2317/94
摘要： Various bispecific antibodies that specifically bind to both blood coagulation factor IX/activated blood coagulation factor IX and blood coagulation factor X and functionally substitute for the cofactor function of blood coagulation factor VIII, that is, the function to promote activation of blood coagulation factor X by activated blood coagulation factor IX, were produced. From these antibodies, multispecific antigen-binding molecules having a high activity of functionally substituting for blood coagulation factor VIII were successfully discovered.
摘要翻译： 与血液凝固因子IX /激活的凝血因子IX和血液凝固因子X特异性结合并且在功能上取代凝血因子VIII的辅因子功能的各种双特异性抗体，即通过以下方式促进血液凝固因子X活化的功能： 产生活化的凝血因子IX。 从这些抗体中成功发现了功能性取代凝血因子VIII的多特异性抗原结合分子。
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公开(公告)号：EP3981794A1
公开(公告)日：2022-04-13
申请号：EP21192849.4
申请日：2015-12-18
发明人： RUIKE, Yoshinao , SAMPEI, Zenjiro
摘要： An objective of the invention is to provide anti-C5 antibodies and methods of using the same. The invention provides anti-C5 antibodies and methods of using the same. In some embodiments, an isolated anti-C5 antibody of the present invention binds to an epitope within the beta chain of C5 with a higher affinity at neutral pH than at acidic pH. The invention also provides isolated nucleic acids encoding an anti-C5 antibody of the present invention. The invention also provides host cells comprising a nucleic acid of the present invention. The invention also provides a method of producing an antibody comprising culturing a host cell of the present invention so that the antibody is produced. The invention further provides a method of producing an anti-C5 antibody comprising immunizing an animal against a polypeptide which comprises the MG1-MG2 domain of the beta chain of C5. Anti-C5 antibodies of the present invention may be for use as a medicament.
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公开(公告)号：EP3765494A1
公开(公告)日：2021-01-20
申请号：EP19767801.4
申请日：2019-03-15
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公开(公告)号：EP3577135A1
公开(公告)日：2019-12-11
申请号：EP18710159.7
申请日：2018-01-31
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