公开(公告)号：EP2734518B1

公开(公告)日：2016-04-27

申请号：EP12743518.8

申请日：2012-07-17

申请人： Cisbio Bioassays ,  Ecole Normale Supérieure de Lyon ,  Centre National de la Recherche Scientifique

发明人： LAMARQUE, Laurent ,  MAURY, Olivier ,  PARKER, David ,  ZWIER, Jurriaan ,  WALTON, James W. ,  BOURDOLLE, Adrien

IPC分类号： C07D401/14 ,  C07F9/6558 ,  G01N33/58

CPC分类号： C07F5/003 ,  C07D255/02 ,  C07D401/14 ,  C07F9/65583

公开(公告)号：EP2464973B1

公开(公告)日：2016-10-05

申请号：EP10761046.1

申请日：2010-08-12

申请人： CISBIO BIOASSAYS ,  Centre National de la Recherche Scientifique

发明人： TRINQUET, Eric ,  ZWIER, Jurriaan ,  MATHIS, Gérard ,  PIN, Jean-Philippe ,  DURROUX, Thierry

IPC分类号： G01N33/74 ,  G01N33/542

CPC分类号： G01N33/542 ,  G01N33/74

公开(公告)号：EP2734518A1

公开(公告)日：2014-05-28

申请号：EP12743518.8

申请日：2012-07-17

申请人： Cisbio Bioassays ,  Ecole Normale Superieure De Lyon ,  Centre National de la Recherche Scientifique

发明人： LAMARQUE, Laurent ,  MAURY, Olivier ,  PARKER, David ,  ZWIER, Jurriaan ,  WALTON, James W. ,  BOURDOLLE, Adrien

IPC分类号： C07D401/14 ,  C07F9/6558 ,  G01N33/58

CPC分类号： C07F5/003 ,  C07D255/02 ,  C07D401/14 ,  C07F9/65583

摘要： The aim of the present invention is to produce complexing agents of formula (I), in which a, b, c, Chrom
1 , Chrom
2 , Chrom
3 , R
3 , R
4 and R
5 are as defined in the description. The invention also concerns lanthanide complexes comprising said complexing agents, as well as a method for synthesising said agents.

公开(公告)号：EP3386974B1

公开(公告)日：2020-02-05

申请号：EP16825810.1

申请日：2016-12-09

申请人： CISBIO BIOASSAYS ,  Université Paul Sabatier ,  Centre National de la Recherche Scientifique

发明人： LAMARQUE, Laurent ,  PICARD, Claude ,  GALAUP, Chantal ,  LEYGUE, Nadine ,  ZWIER, Jurriaan ,  BOURRIER, Emmanuel

IPC分类号： C07D401/14 ,  C07F15/00 ,  C07F3/00

公开(公告)号：EP3386974A1

公开(公告)日：2018-10-17

申请号：EP16825810.1

申请日：2016-12-09

申请人： CISBIO BIOASSAYS ,  Université Paul Sabatier ,  Centre National de la Recherche Scientifique

发明人： LAMARQUE, Laurent ,  PICARD, Claude ,  GALAUP, Chantal ,  LEYGUE, Nadine ,  ZWIER, Jurriaan ,  BOURRIER, Emmanuel

IPC分类号： C07D401/14 ,  C07F15/00 ,  C07F3/00

CPC分类号： C07F5/003 ,  C07D401/14 ,  G01N33/582 ,  G01N2458/40

摘要： The invention relates to complexing agents of formula (I), in which A1, A2, A3 and R1 are as defined in the description. The invention likewise relates to lanthanide complexes obtained from said complexing agents. The invention can be used for marking biological molecules.

公开(公告)号：EP2425249B1

公开(公告)日：2014-07-16

申请号：EP10727062.1

申请日：2010-04-29

申请人： CISBIO BIOASSAYS ,  Centre National de la Recherche Scientifique

发明人： DOUMAZANE, Etienne ,  ZWIER, Jurriaan ,  TRINQUET, Eric ,  PIN, Jean-Philippe

IPC分类号： G01N33/542 ,  G01N33/94

CPC分类号： G01N33/542 ,  G01N33/9426 ,  G01N2333/726 ,  G01N2500/04

公开(公告)号：EP2464973A2

公开(公告)日：2012-06-20

申请号：EP10761046.1

申请日：2010-08-12

申请人： CIS bio international ,  Centre National de la Recherche Scientifique

发明人： TRINQUET, Eric ,  ZWIER, Jurriaan ,  MATHIS, Gérard ,  PIN, Jean-Philippe ,  DURROUX, Thierry

IPC分类号： G01N33/542

CPC分类号： G01N33/542 ,  G01N33/74

摘要： The invention relates to a method that makes it possible to predetermine if a compound to be tested preferably binds to a membrane receptor R1 or to a membrane receptor R2, said receptors being known to be expressed as a monomeric, homodimeric, or heterodimeric receptor on the surface of cells. Said method is implemented through the use of one or two FRET partner pairs.

公开(公告)号：EP2425249A1

公开(公告)日：2012-03-07

申请号：EP10727062.1

申请日：2010-04-29

申请人： CIS Bio International ,  Centre National de la Recherche Scientifique

发明人： DOUMAZANE, Etienne ,  ZWIER, Jurriaan ,  TRINQUET, Eric ,  PIN, Jean-Philippe

IPC分类号： G01N33/542

CPC分类号： G01N33/542 ,  G01N33/9426 ,  G01N2333/726 ,  G01N2500/04

摘要： The invention relates to a method for selecting compounds having a modulating effect on the activation state of a dimer of VFT domain proteins expressed in cellular membranes in a measuring medium, said dimer including a first protein and a second protein which are identical or different, wherein the method includes the following steps: (a) marking the first and second proteins in the N-terminal portion of the VFT domain by members of a FRET partner pair, the Förster radius (R
0 ) of said pair ranging between 20 and 55 Å; (b) measuring the FRET signal in the absence and in the presence of the compound to be tested within a predetermined time window; (c) selecting the compound to be tested as a modulating compound if a difference in the FRET signal in the absence and in the presence of the compound to be tested is measured during step (b). The invention can be used in the research for new drugs and new taste modulators.

公开(公告)号：EP3638660A1

公开(公告)日：2020-04-22

申请号：EP18749428.1

申请日：2018-06-13

申请人： CISBIO BIOASSAYS

发明人： LAMARQUE, Laurent ,  ZWIER, Jurriaan ,  BOURRIER, Emmanuel

IPC分类号： C07D401/14 ,  C07F9/30 ,  G01N33/52

公开(公告)号：EP3992182A1

公开(公告)日：2022-05-04

申请号：EP20306296.3

申请日：2020-10-28

申请人： Cisbio Bioassays

发明人： PARKER, David ,  FRADGLEY, Jack ,  STARCK, Matthieu ,  ZWIER, Jurriaan ,  LAMARQUE, Laurent

IPC分类号： C07D213/36 ,  C07F5/00 ,  C09K11/06 ,  G01N33/58

摘要： The invention relates to a compound of formula (I):

wherein R 1 , R 2 , R 3 and R 4 are as defined in the description.
The invention also relates to europium (III) complexes obtained from a compound of formula (I), or from a complexing agent including said compound, and to the use of such complexes to label organic or biological molecules.