公开(公告)号：EP3386974A1

公开(公告)日：2018-10-17

申请号：EP16825810.1

申请日：2016-12-09

申请人： CISBIO BIOASSAYS ,  Université Paul Sabatier ,  Centre National de la Recherche Scientifique

发明人： LAMARQUE, Laurent ,  PICARD, Claude ,  GALAUP, Chantal ,  LEYGUE, Nadine ,  ZWIER, Jurriaan ,  BOURRIER, Emmanuel

IPC分类号： C07D401/14 ,  C07F15/00 ,  C07F3/00

CPC分类号： C07F5/003 ,  C07D401/14 ,  G01N33/582 ,  G01N2458/40

摘要： The invention relates to complexing agents of formula (I), in which A1, A2, A3 and R1 are as defined in the description. The invention likewise relates to lanthanide complexes obtained from said complexing agents. The invention can be used for marking biological molecules.

公开(公告)号：EP2635585B1

公开(公告)日：2017-11-01

申请号：EP11788783.6

申请日：2011-11-04

申请人： Inkidia S.R.L.

发明人： PAVONE, Vincenzo ,  NASTRI, Flavia ,  MAGLIO, Ornella ,  LOMBARDI, Angelina

IPC分类号： C07D487/22 ,  A61K39/00

CPC分类号： C07D487/22 ,  A61K39/00 ,  G01N2458/40

公开(公告)号：EP3212733A1

公开(公告)日：2017-09-06

申请号：EP15790066.3

申请日：2015-10-27

申请人： Radiometer Turku Oy

发明人： TAKALO, Harri ,  SUND, Henri

IPC分类号： C09K11/06

CPC分类号： C09K11/06 ,  C07D401/14 ,  C07K16/18 ,  C09K2211/1007 ,  C09K2211/1029 ,  C09K2211/182 ,  G01N33/533 ,  G01N2458/40

摘要： The present application discloses novel azamacrocyclic lanthanide chelate design (Formula (I)) having substituted 4-(phenylethynyl)pyridine chromophores around an emitting lanthanide core, e.g. an europium(III) ion. The chromophores exhibit high molar absorptivity and luminescence with lanthanide ions. The application also discloses a detectable molecule comprising a biospecific binding reagent conjugated to the luminescent chelate, luminescent lanthanide chelating ligand as well as a solid support conjugated with the chelates and their use in various assays.

摘要翻译： 本申请公开了具有取代的发光镧系核心周围的4-（苯基乙炔基）吡啶发色团的新型氮杂大环镧系元素螯合物设计（式（I））， 铕（III）离子。 发色团显示高摩尔吸收率和镧系元素离子发光。 本申请还公开了包含与发光螯合物，发光镧系元素螯合配体缀合的生物特异性结合试剂的可检测分子，以及与螯合物缀合的固体载体以及它们在各种测定中的用途。

公开(公告)号：EP3037498A4

公开(公告)日：2017-04-26

申请号：EP14837719

申请日：2014-08-18

申请人： MEDISENSOR INC

发明人： KIM SO YEON ,  HEO NAE YOUNG ,  JUNG JEAAN ,  KIM WON JUNG ,  HWANG BYUNG GAP ,  KIM YOUNG SEOP ,  LEE MYOUNG HOON

IPC分类号： C09K11/02 ,  C09K11/06 ,  C09K11/08 ,  C09K11/58 ,  G01N33/533 ,  G01N33/58

CPC分类号： G01N33/587 ,  C09K11/025 ,  C09K11/06 ,  C09K11/58 ,  C09K2211/1011 ,  C09K2211/1044 ,  C09K2211/1092 ,  C09K2211/182 ,  G01N33/582 ,  G01N33/585 ,  G01N2458/40

摘要： Provided are a fluorescent particle and a method for manufacturing the same. The fluorescent particle may include a gold nanoparticle; a silica shell covering the gold nanoparticle; and lanthanide group complex particles dispersed in the silica shell. Each of the lanthanide group complex particles may include a lanthanide group ion; a ligand bonded to the lanthanide group ion and including phosphorus; and a ligand bonded to the lanthanide group ion and having a beta diketone functional group. The fluorescent particle is observable with the naked eye and may emit light when ultraviolet light is irradiated. The fluorescent particle may be used for detecting and analyzing biomaterial samples.

摘要翻译： 提供荧光颗粒及其制造方法。 荧光颗粒可以包括金纳米颗粒; 覆盖金纳米颗粒的二氧化硅壳; 和分散在二氧化硅壳中的镧系复合颗粒。 每个镧系元素络合物颗粒可以包括镧系元素离子; 与镧系元素离子键合并包含磷的配体; 和与镧系元素离子键合并具有β二酮官能团的配体。 荧光颗粒可以用肉眼观察到，并且当照射紫外线时可以发光。 荧光颗粒可用于检测和分析生物材料样品。

公开(公告)号：EP2329272B1

公开(公告)日：2013-10-09

申请号：EP09740420.6

申请日：2009-07-30

申请人： Ion Beam Applications

发明人： ZWIER, Jurriaan ,  POOLE, Robert ,  ANSANAY, Hervé ,  FINK, Michel ,  TRINQUET, Eric

IPC分类号： G01N33/566 ,  G01N33/58

CPC分类号： G01N33/542 ,  G01N33/5035 ,  G01N33/58 ,  G01N2458/40 ,  Y10T436/13

公开(公告)号：EP1784753B1

公开(公告)日：2013-03-20

申请号：EP05783374.1

申请日：2005-08-08

申请人： GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.

发明人： YANG, Jenny, J.

IPC分类号： G01N33/542 ,  G01N33/84

CPC分类号： G01N33/84 ,  G01N33/542 ,  G01N2458/40

公开(公告)号：EP1903075B1

公开(公告)日：2010-01-27

申请号：EP07017859.5

申请日：2007-09-12

申请人： FUJIFILM Corporation

发明人： Makino, Naonori, c/o Fujifilm Corporation

IPC分类号： C08L51/00 ,  G01N33/533

CPC分类号： C08F265/04 ,  C08F290/06 ,  C08F290/061 ,  C08L51/003 ,  G01N33/533 ,  G01N2458/40 ,  C08L2666/02

公开(公告)号：EP2092084A2

公开(公告)日：2009-08-26

申请号：EP07868748.0

申请日：2007-11-13

申请人： Perkinelmer LAS, Inc.

发明人： ROBY, Philippe ,  PARENT, Stephane

IPC分类号： C12Q1/68

CPC分类号： G01N33/542 ,  G01N33/533 ,  G01N33/54313 ,  G01N33/582 ,  G01N33/585 ,  G01N2440/14 ,  G01N2458/40 ,  Y10T436/143333

摘要： The present disclosure features a variety of compositions, kits, and methods that are useful for, inter alia, detecting and/or analyzing an interaction between two molecules, a target molecule and a target-specific binding agent which can be, e.g., proteins, nucleic acids, saccharides or polysaccharides, small molecules, or combinations of any of the foregoing. The compositions, kits, and methods can also be used, e.g., to detect the presence or absence of an enzymatic activity (e.g., a kinase activity, a protease activity, or a phosphatase activity) in a sample; to identify a compound that modulates an interaction between two molecules; or to identify compounds that modulate the activity of an enzyme.

公开(公告)号：EP2056709A1

公开(公告)日：2009-05-13

申请号：EP07814007.6

申请日：2007-08-11

申请人： The University of Medicine and Dentistry of New Jersey

发明人： MUSTAEV, Arkady ,  MARRAS, Salvatore, A.E.

IPC分类号： A61B5/00

CPC分类号： G01N33/582 ,  A61K47/481 ,  A61K47/48115 ,  A61K47/55 ,  A61K47/552 ,  A61K49/0019 ,  A61K49/0021 ,  C07F5/00 ,  C12Q1/6818 ,  G01N2458/30 ,  G01N2458/40

摘要： The invention relates to novel luminescent compositions of matter containing two fluorophores (sensitizers), synthetic methods for making the compositions, macromolecular conjugates of the compositions, and the use of the compositions and their conjugates in various methods of detection. The invention also provides kits containing the compositions and their conjugates for use in the methods of detection.

摘要翻译： 本发明涉及含有两种荧光团（敏化剂）的物质的新型发光组合物，用于制备组合物的合成方法，组合物的大分子缀合物，以及组合物及其缀合物在各种检测方法中的用途。 本发明还提供了包含用于检测方法的组合物及其缀合物的试剂盒。

公开(公告)号：EP1290448B1

公开(公告)日：2007-11-07

申请号：EP01951580.8

申请日：2001-06-12

申请人： CIS BIO INTERNATIONAL

发明人： AUTIERO, Hervé ,  BAZIN, Hervé ,  MATHIS, Gérard

IPC分类号： G01N33/58 ,  C07D471/22

CPC分类号： G01N33/582 ,  C07D471/22 ,  G01N2458/40

摘要： The invention relates to a process for reducing the fluorescence quenching caused by the measuring medium in a fluorescence assay, by introducing into said medium of rare earth metal cryptates comprising at least one pyrdine radical which is substituted one or more times or unsubstituted. The invetion also relates to novel rare metal cryptates which are not very sensitive to the fluorescence quenching caused by the measuring medium.