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    A NANOCOMPOSITE LAYER ON THE BASIS OF COLLAGEN NANOFIBERS, AND A METHOD OF PREPARATION THEREOF
    4.
    发明公开
    A NANOCOMPOSITE LAYER ON THE BASIS OF COLLAGEN NANOFIBERS, AND A METHOD OF PREPARATION THEREOF 审中-公开
    基于胶原纳米纤维的纳米复合层及其制备方法

    公开(公告)号：EP3311854A1

    公开(公告)日：2018-04-25

    申请号：EP17197245.8

    申请日：2017-10-19

    申请人： Ústav Struktury A Mechaniky Hornin AV CR, V.V.I. ,  Ceské Vysoké Ucení Technické V Praze Fakulta Strojni ,  ProSpon spol. s.r.o. ,  Contipro a.s.

    发明人： SUCHY, Tomas ,  SUPOVA, Monika ,  DENK, Frantisek ,  RYGLOVA, Sarka ,  ZALOUDKOVA, Margit ,  SUCHARDA, Zbynek ,  BALLAY, Rastislav ,  HORNY, Lukas ,  CEJKA, Zdenek ,  POKORNY, Marek ,  KNOTKOVA, Katerina ,  VELEBNY, Vladimir

    IPC分类号： A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L27/58

    摘要： The subject of the invention is a bioactive nanocomposite layer prepared by the combination of electrospinning and electroblowing of a collagen solution comprising hydroxyapatite nanoparticles and poly(ethylene oxide), where, after the preparation and the crosslinking, the layer consists of 75 to 100 wt. % of collagen type I fibres, 5 - 15 wt. % of hydroxyapatite, and 0 - 1 wt. % of poly(ethylene oxide). The subject of this invention is also a method of production of said layer and a method of depositing antibiotics for a more effective releasing thereof without increasing the cytotoxicity. Said method comprises the impregnation of crosslinked sterilized collagen/hydroxyapatite layers with antibiotics in the form of a solution. The subject of the invention also comprises orthopaedic and dental implants based on metal or metal alloys, electrostatically coated with said composite layer based on collagen nanofibers with integrated hydroxyapatite nanoparticles and an antibiotic or a combination of antibiotics.

    摘要翻译： 本发明的主题是通过包含羟基磷灰石纳米颗粒和聚（氧化乙烯）的胶原溶液的静电纺丝和电吹的组合制备的生物活性纳米复合材料层，其中在制备和交联之后，该层由75至100wt。 ％的I型胶原蛋白，5-15wt。 ％的羟基磷灰石和0-1wt。 ％的聚（氧化乙烯）。 本发明的主题还在于生产所述层的方法和沉积抗生素以更有效地释放它们而不增加细胞毒性的方法。 所述方法包括用溶液形式的抗生素浸渍交联的无菌胶原/羟基磷灰石层。 本发明的主题还包括基于金属或金属合金的整形外科和牙科植入物，静电涂覆有基于具有整合的羟基磷灰石纳米颗粒和抗生素或抗生素组合的胶原纳米纤维的所述复合层。