公开(公告)号：EP1846764A2

公开(公告)日：2007-10-24

申请号：EP05856040.0

申请日：2005-12-29

Applicant: Corning Incorporated

Inventor： PIECH, Garrett A ,  PENG, Jinlin ,  FRUTOS, Anthony G ,  CARRACCI, Stephen J ,  WEBB, Michael Brian

IPC: G01N33/543

CPC classification number: B01L3/5085 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00367 ,  B01J2219/00378 ,  B01J2219/00382 ,  B01J2219/00385 ,  B01J2219/00387 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00662 ,  B01J2219/00677 ,  B01J2219/00693 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L2200/12 ,  B01L2200/148 ,  B01L2300/0636 ,  B01L2300/0829 ,  G01N21/553 ,  G01N21/7743 ,  G01N2035/00158

Abstract: A method is described herein that can use any one of a number of deposition techniques to create a reference region and a sample region on a single biosensor which in the preferred embodiment is located within a single well of a microplate. The deposition techniques that can be used to help create the reference region and the sample region on a surface of the biosensor include: (1) the printing/stamping of a deactivating agent on a reactive surface of the biosensor; (2) the printing/stamping of a target molecule (target protein) on a reactive surface of the biosensor; or (3) the printing/stamping of a reactive agent on an otherwise unreactive surface of the biosensor.

公开(公告)号：EP3924322A1

公开(公告)日：2021-12-22

申请号：EP20710334.2

申请日：2020-01-27

Applicant: Corning Incorporated

Inventor： AYRES, Raymond Victor ,  BUBB, Keith Norman ,  SHULTZ, Michael George ,  TEPESCH, Patrick David ,  WEBB, Michael Brian ,  ZHOU, Qing ,  ZHUANG, Cheng-Gang

IPC: C04B41/45 ,  C04B41/00 ,  C04B38/00 ,  C04B41/50 ,  C04B41/87 ,  B01D46/24 ,  B28B11/00 ,  C04B111/00

公开(公告)号：EP1996917A2

公开(公告)日：2008-12-03

申请号：EP07867000.7

申请日：2007-02-20

Applicant: Corning Incorporated

Inventor： GOLLIER, Jacques ,  PIECH, Garrett A. ,  WEBB, Michael Brian ,  WU, Qi

IPC: G01N21/27

CPC classification number: G01J3/28 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/1895 ,  G01J3/2803 ,  G01N21/7743

Abstract: An optical interrogation system is described herein that can interrogate a label-independent-detection (LID) biosensor and monitor a biological event on top of the biosensor without suffering from problematical parasitic reflections and/or problematical pixelation effects. In one embodiment, the optical interrogation system is capable of interrogating a biosensor and using a low pass filter algorithm to digitally remove problematic parasitic reflections contained in the spectrum of an optical resonance which makes it easier to determine whether or not a biological event occurred on the biosensor. In another embodiment, the optical interrogation system is capable of interrogating a biosensor and using an oversampling/smoothing algorithm to reduce oscillations in the estimated location of an optical resonance caused by the problematical pixelation effect which makes it easier to determine whether or not a biological event occurred on the biosensor.

公开(公告)号：EP1846764B1

公开(公告)日：2010-09-01

申请号：EP05856040.0

申请日：2005-12-29

Applicant: Corning Incorporated

Inventor： CARRACCI, Stephen J. ,  FRUTOS, Anthony G. ,  PENG, Jinlin ,  PIECH, Garrett A. ,  WEBB, Michael Brian

IPC: G01N33/543

CPC classification number: B01L3/5085 ,  B01J19/0046 ,  B01J2219/00315 ,  B01J2219/00367 ,  B01J2219/00378 ,  B01J2219/00382 ,  B01J2219/00385 ,  B01J2219/00387 ,  B01J2219/00576 ,  B01J2219/00585 ,  B01J2219/00596 ,  B01J2219/00605 ,  B01J2219/0061 ,  B01J2219/00612 ,  B01J2219/00617 ,  B01J2219/00626 ,  B01J2219/0063 ,  B01J2219/00637 ,  B01J2219/00662 ,  B01J2219/00677 ,  B01J2219/00693 ,  B01J2219/00722 ,  B01J2219/00725 ,  B01L2200/12 ,  B01L2200/148 ,  B01L2300/0636 ,  B01L2300/0829 ,  G01N21/553 ,  G01N21/7743 ,  G01N2035/00158

Abstract: A method is described herein that can use any one of a number of deposition techniques to create a reference region and a sample region on a single biosensor which in the preferred embodiment is located within a single well of a microplate. The deposition techniques that can be used to help create the reference region and the sample region on a surface of the biosensor include: (1) the printing/stamping of a deactivating agent on a reactive surface of the biosensor; (2) the printing/stamping of a target molecule (target protein) on a reactive surface of the biosensor; or (3) the printing/stamping of a reactive agent on an otherwise unreactive surface of the biosensor.