公开(公告)号：EP1578905A2

公开(公告)日：2005-09-28

申请号：EP02765778.2

申请日：2002-06-04

申请人： Curagen Corporation

发明人： AGEE, Michele L. ,  ANDERSON, David W. ,  BERGHS, Constance ,  CASMAN, Stacie J. ,  CATTERTON, Elina ,  DIPIPPO, Vincent A. ,  EDINGER, Shlomit R. ,  EISEN, Andrew ,  ELLERMAN, Karen ,  GANGOLLI, Esha A. ,  GERLACH, Valerie L. ,  GORMAN, Linda ,  GUO, Xiaojia ,  HERRMANN, John L. ,  HJALT, Tord ,  JI, Weizhen ,  KEKUDA, Ramesh ,  KHRAMTSOV, Nikolai V. ,  LI, Li ,  LIU, Xiaohong ,  MALYANKAR, Uriel M. ,  MILLER, Charles E. ,  MILLET, Isabelle ,  ORT, Tatiana ,  PADIGARU, Muralidhara ,  PATTURAJAN, Meera ,  PENA, Carol E.A. ,  RASTELLI, Luca ,  RIEGER, Daniel K. ,  ROTHENBERG, Mark E. ,  SHENOY, Suresh G. ,  SHIMKETS, Richard A. ,  SMITHSON, Glennda ,  SPADERNA, Steven K. ,  SPYTEK, Kimberly A. ,  STONE, David J. ,  VERNET, Corine A.M. ,  ZHONG, Haihong ,  ZHONG, Mei ,  ALSOBROOK, John P.,II ,  BURGESS, Catherine E. ,  LEPLEY, Denise M.

IPC分类号： C12N1/00

摘要： The present invention provides novel isolated polynucleotides and small molecule target polypeptides encoded by the polynucleotides. Antibodies that immunospecifically bind to a novel small molecule target polypeptide or any derivative, variant, mutant or fragment of that polypeptide, polynucleotide or antibody are disclosed, as are methods in which the small molecule target polypeptide, polynucleotide and antibody are utilized in the detection and treatment of a broad range of pathological states. More specifically, the present invention discloses methods of using recombinantly expressed and/or endogenously expressed proteins in various screening procedures for the purpose of identifying therapeutic antibodies and therapeutic small molecules associated with diseases.

摘要翻译： 本发明提供了由多核苷酸编码的新的分离的多核苷酸和小分子靶多肽。 公开了免疫特异性结合新型小分子靶多肽或该多肽，多核苷酸或抗体的任何衍生物，变体，突变体或片段的抗体，其中小分子靶多肽，多核苷酸和抗体用于检测和 治疗广泛的病理状态。 更具体地，本发明公开了在各种筛选过程中使用重组表达的和/或内源表达的蛋白质以鉴定治疗性抗体和与疾病相关的治疗性小分子的方法。